{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:36:22Z","timestamp":1784637382076,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Intravenous iron is widely used for the treatment of iron deficiency anemia when adherence to oral iron replacement is poor. Acute hypersensitivity reactions during iron infusions are very rare but can be life threatening. Major risk factors for hypersensitivity reactions include a previous reaction to an iron infusion, a fast iron infusion rate, multiple drug allergies, atopic diseases, high serum tryptase levels, asthma, and urticaria. The management of iron infusions requires meticulous observation, and, in the event of an adverse reaction, prompt recognition and severity-related interventions by well-trained medical and nursing staff. Avoidance of IV iron products in patients with iron hypersensitivity reactions may not be considered as a standard practice.<\/jats:p>","DOI":"10.3390\/children9101473","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:23:27Z","timestamp":1664313807000},"page":"1473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hypersensitivity to Intravenous Iron Preparations"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-524X","authenticated-orcid":false,"given":"Silvia","family":"Caimmi","sequence":"first","affiliation":[{"name":"UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Crisafulli","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Universit\u00e0 di Messina, 98124 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Franceschini","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Azienda Ospedaliero-Universitaria \u201cOspedali Riuniti\u201d, 60020 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-2796","authenticated-orcid":false,"given":"Lucia","family":"Liotti","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Azienda Ospedaliero-Universitaria \u201cOspedali Riuniti\u201d, 60020 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Bianchi","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bottau","sequence":"additional","affiliation":[{"name":"Dipartimento di Pediatria e Neonatologia, Ospedale di Imola, 40026 Imola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mori","sequence":"additional","affiliation":[{"name":"Allergy Unit, Meyer Children\u2019s Hospital, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Triggiano","sequence":"additional","affiliation":[{"name":"UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Paglialunga","sequence":"additional","affiliation":[{"name":"UOC di Pediatria, Azienda Ospedaliera-Universitaria \u201cConsorziale-Policlinico\u201d, Ospedale Pediatrico Giovanni XXIII, 70123 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-5483","authenticated-orcid":false,"given":"Francesca","family":"Saretta","sequence":"additional","affiliation":[{"name":"SC Pediatria, Ospedale Latisana-Palmanova, Dipartimento Materno-Infantile Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Giannetti","sequence":"additional","affiliation":[{"name":"Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caffarelli","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica, Azienda Ospedaliero-Universitaria, Dipartimento Medicina e Chirurgia, Universit\u00e0 di Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1016\/S2352-3026(19)30264-9","article-title":"Intravenous iron: A framework for changing the management of iron deficiency","volume":"7","author":"Auerbach","year":"2020","journal-title":"Lancet Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Funk, F., Fluhmann, B., and Barton, A.E. (2022). Criticality of Surface Characteristics of Intravenous Iron\u2013Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042140"},{"key":"ref_3","first-page":"137","article-title":"Management of acute intravenous iron reactions","volume":"17","author":"Shander","year":"2019","journal-title":"Blood Transfus."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ndt\/gfi253","article-title":"Update on adverse drug events associated with parenteral iron","volume":"21","author":"Chertow","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/pds.5319","article-title":"Use of intravenous iron and risk of anaphylaxis: A multinational observational post-authorisation safety study in Europe","volume":"30","author":"Fortuny","year":"2021","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1824-7288-38-43","article-title":"Exercise-induced anaphylaxis: A clinical view","volume":"38","author":"Caffarelli","year":"2012","journal-title":"Ital. J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1111\/bph.13268","article-title":"Hypersensitivity to intravenous iron: Classification, terminology, mechanisms and management","volume":"172","author":"Szebeni","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.jaip.2021.01.009","article-title":"Management of hypersensitivity reactions to non-dextran iron products: New insights into predisposing risk factors","volume":"9","author":"Meienberg","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.iac.2014.04.013","article-title":"Hypersensitivity to intravenous iron products","volume":"34","author":"Bircher","year":"2014","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s40264-020-01022-2","article-title":"Frequency and Associated Costs of Anaphylaxis- and Hypersensitivity-Related Adverse Events for Intravenous Iron Products in the USA: An analysis using the US Food and Drug Administration Adverse Event Reporting System","volume":"44","author":"Trumbo","year":"2021","journal-title":"Drug Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/M21-4009","article-title":"Risks for anaphylaxis with intravenous iron formulations: A retrospective cohort study","volume":"175","author":"Dave","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/pbc.22930","article-title":"Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy","volume":"56","author":"Crary","year":"2011","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/MPH.0000000000000879","article-title":"Intravenous iron sucrose for children with iron deficiency anemia","volume":"39","author":"Kaneva","year":"2017","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e26995","DOI":"10.1002\/pbc.26995","article-title":"Utilization trends and safety of intravenous iron replacement in pediatric specialty care: A large retrospective cohort study","volume":"65","author":"Boucher","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e27016","DOI":"10.1002\/pbc.27016","article-title":"Intravenous iron: Safe and underutilized in children","volume":"65","author":"Mantadakis","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_16","unstructured":"NIH (2022, September 10). Multicenter Randomized Active-Controlled Study to Investigate Efficacy & Safety of IV FCM in Pediatric Patients with IDA. Identifier: NCT03523117, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03523117."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40272-022-00491-5","article-title":"Safety of ferric carboxymaltose in children: Report of a case series from Greece and review of literature","volume":"24","author":"Panagopoulou","year":"2022","journal-title":"Pediatric. Drug"},{"key":"ref_18","unstructured":"European Medicines Agency (2022, June 30). New Recommendations to Manage Risk of Allergic Reactions with Intravenous Iron-Containing Medicines. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/press-release\/new-recommendations-manage-risk-allergic-reactions-intravenous-iron-containing-medicines_en.pdf."},{"key":"ref_19","first-page":"s93","article-title":"Structure, chemistry and pharmacokinetics of intravenous iron agents","volume":"15","author":"Danielson","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Neiser, S., Koskenkorva, T.S., Schwarz, K., Wilhelm, M., and Burckhardt, S. (2016). Assessment of dextran antigenicity of intravenous iron preparations with Enzyme-Linked Immunosorbent Assay (ELISA). Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071185"},{"key":"ref_21","first-page":"219","article-title":"Assessment of dextran antigenicity of intravenous iron products by an Immunodiffusion assay","volume":"25","author":"Neiser","year":"2011","journal-title":"Port J. Nephrol. Hypertens."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000451069","article-title":"Complement activation-related pseudo-allergy: A fresh look at hypersensitivity reactions to intravenous iron","volume":"45","author":"Macdougall","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000451060","article-title":"Distinct in vitro complement activation by various intravenous iron preparations","volume":"45","author":"Hempel","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3324\/haematol.2014.111492","article-title":"Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management","volume":"99","author":"Rampton","year":"2014","journal-title":"Haematologica"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jaip.2020.11.028","article-title":"Safety of intravenous iron following infusion reactions","volume":"9","author":"Stojanovic","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jpeds.2016.09.053","article-title":"Intravenous ferric carboxymaltose in children with iron deficiency anemia who respond poorly to oral iron","volume":"180","author":"Powers","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e28614","DOI":"10.1002\/pbc.28614","article-title":"Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents","volume":"67","author":"Ozsahin","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/jpc.14686","article-title":"Ferric carboxymaltose infusions are well tolerated in children under 14 years old, a single-centre experience","volume":"55","author":"Hong","year":"2019","journal-title":"J. Paediatr. Child Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/bcp.13493","article-title":"Safety and efficacy of parenteral iron in children with inflammatory bowel disease: Safety and efficacy of parenteral iron in children with IBD","volume":"84","author":"Papadopoulos","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0272-6386(96)90463-1","article-title":"The safety of intravenous iron dextran in hemodialysis patients","volume":"28","author":"Fishbane","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/14740338.2021.1912010","article-title":"Newer formulations of intravenous iron: A review of their chemistry and key safety aspects, hypersensitivity, hypophosphatemia, and cardiovascular safety","volume":"20","author":"Blumestein","year":"2021","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/vox.12773","article-title":"Canadian expert consensus: Management of hypersensitivity reactions to intravenous iron in adults","volume":"114","author":"Lim","year":"2019","journal-title":"Vox Sang."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1182\/asheducation-2010.1.338","article-title":"Clinical use of intravenous iron: Administration, efficacy, and safety","volume":"1","author":"Auerbach","year":"2010","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Carr\u00f3n-Herrero, A., Fern\u00e1ndez-Lozano, C., Botella-Carretero, J.I., Palomino-Quintanilla, L., Martinez-Botas, J., and Solnao-Solares, E. (J. Investig. Allergol. Clin. Immunol., 2022). Delayed hypersensitivity reaction to iron salts: From diagnosis to desensitization, J. Investig. Allergol. Clin. Immunol., epub ahead of print.","DOI":"10.18176\/jiaci.0789"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Caglayan-Sozmen, S., Santoro, A., Cipriani, F., Mastrorilli, C., Ricci, G., and Caffarelli, C. (2019). Hazardous medications in children with egg, red meat, gelatin, fish, and cow\u2019s milk allergy. Medicina, 55.","DOI":"10.3390\/medicina55080501"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1159\/000503768","article-title":"Desensitization in iron product allergy","volume":"143","author":"Albanesi","year":"2020","journal-title":"Acta Haematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","article-title":"Drug provocation testing in the diagnosis of drug hypersensitivity reactions: General considerations","volume":"58","author":"Aberer","year":"2003","journal-title":"Allergy"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13052-018-0589-3","article-title":"SIAIP position paper: Provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children","volume":"44","author":"Caffarelli","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/all.13037","article-title":"Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity","volume":"72","author":"Chiriac","year":"2017","journal-title":"Allergy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.anai.2012.02.001","article-title":"Blood pressure monitoring in children undergoing food challenge: Association with anaphylaxis","volume":"108","author":"Caffarelli","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mori, F., Saretta, F., Bianchi, A., Crisafulli, G., Caimmi, S., Liotti, L., Bottau, P., Franceschini, F., Paglialunga, C., and Ricci, G. (2020). Hypersensitivity reactions to monoclonal antibodies in children. Medicina, 5.","DOI":"10.3390\/medicina56050232"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1365-2141.2001.03166.x","article-title":"Complement activation plays a key role in the side-effects of rituximab treatment","volume":"115","author":"Baars","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-109-4-346","article-title":"Successful prevention of an anaphylactoid reaction to iron dextran","volume":"109","author":"Altman","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/all.13106","article-title":"Approach to hypersensitivity reactions from intravenous iron preparations","volume":"72","author":"Bircher","year":"2017","journal-title":"Allergy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/1574886311666151209114203","article-title":"A safe and novel desensitization protocol with ferric carboxymaltose to treat iron deficiency anemia","volume":"11","author":"Montandon","year":"2016","journal-title":"Curr. Drug Saf."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000368407","article-title":"A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts","volume":"165","author":"Demir","year":"2014","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_47","first-page":"38","article-title":"Two case reports of desensitization in patients with hypersensitivity to iron","volume":"10","author":"Chapman","year":"2017","journal-title":"WAO J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.anai.2014.09.009","article-title":"Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, open, parallel-group study","volume":"113","author":"Cadario","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Caffarelli, C., Mastrorilli, C., Procaccianti, M., and Santoro, A. (2020). Use of sublingual immunotherapy for aeroallergens in children with asthma. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103381"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fped.2016.00034","article-title":"Asthma and food allergy in children: Is there a connection or interaction?","volume":"4","author":"Caffarelli","year":"2016","journal-title":"Front. Pediatr."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1473\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:06Z","timestamp":1760143206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["children9101473"],"URL":"https:\/\/doi.org\/10.3390\/children9101473","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}