{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:54:13Z","timestamp":1764557653934,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SICPA Foundation"},{"name":"Soci\u00e9t\u00e9 Acad\u00e9mique Vaudoise"},{"name":"\u201cFonds de Perfectionnement\u201d of the University Hospital Lausanne, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Diastolic dysfunction is an important determinant for prognosis and survival in several paediatric heart diseases. We aimed to explore its possible impact on outcome in children with dilated cardiomyopathy. From 2006 to 2016, children less than 18 years old with dilated cardiomyopathy were retrospectively enrolled. Echocardiographic diastolic function parameters and child outcomes were analysed. Of 43 children aged 0.2 to 16.1 years old referred with dilated cardiomyopathy, 8 patients required cardiac transplant or mechanical assist devices (18%), 24 had persistently abnormal left ventricular function and\/or dilatation (56%) and 11 patients recovered (26%). There was no significant difference in mitral velocities on Tissue Doppler Imaging, mitral valve inflow velocities, isovolumic relaxation time, left atrial area z-score and mitral lateral E\/e\u2019 ratios between patients with recovery and patients with disease progression or persistently abnormal ventricular function and\/or dilation. This is the first study on childhood dilated cardiomyopathy to address individual echocardiographic diastolic function parameters and their association to recovery. In this study, echocardiographic parameters for diastolic function did not predict recovery.<\/jats:p>","DOI":"10.3390\/children9101500","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:52:21Z","timestamp":1665193941000},"page":"1500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the Possible Impact of Echocardiographic Diastolic Function Parameters on Outcome in Paediatric Dilated Cardiomyopathy"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5011-1495","authenticated-orcid":false,"given":"Sabrina","family":"Bressieux-Degueldre","sequence":"first","affiliation":[{"name":"Paediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Fenton","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Burch","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Department, Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1001\/jama.296.15.1867","article-title":"Incidence, causes, and outcomes of dilated cardiomyopathy in children","volume":"296","author":"Towbin","year":"2006","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCULATIONAHA.106.671735","article-title":"British Congenital Cardiac Association. New-onset Heart Failure Due to Heart Muscle Disease in Childhood. A Prospective Study in the United Kingdom and Ireland","volume":"117","author":"Andrews","year":"2008","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1161\/CIRCULATIONAHA.106.635128","article-title":"Clinical features and outcomes of childhood dilated cardiomyopathy: Results from a national population based study","volume":"114","author":"Daubeney","year":"2006","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jacc.2013.11.059","article-title":"Recovery of Echocardiographic Function in Children with Idiopathic Dilated Cardiomyopathy","volume":"63","author":"Everitt","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCHEARTFAILURE.113.000125","article-title":"Predictors of Disease Progression in Pediatric Dilated Cardiomyopathy","volume":"6","author":"Molina","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ppedcard.2007.05.009","article-title":"Outcome predictors for pediatric dilated cardiomyopathy: A systematic review","volume":"23","author":"Alvarez","year":"2007","journal-title":"Prog. Pediatr. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1136\/hrt.2003.020966","article-title":"Echocardiographic predictors of adverse clinical events in children with dilated cardiomyopathy: A prospective clinical study","volume":"90","author":"McMahon","year":"2004","journal-title":"Heart"},{"doi-asserted-by":"crossref","unstructured":"Senekovi\u010d Kojc, T., and Mar\u010dun Varda, N. (2022). Novel Biomarkers of Heart Failure in Pediatrics. Children, 9.","key":"ref_8","DOI":"10.3390\/children9050740"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10554-014-0361-8","article-title":"Early diastolic strain rate predicts response to heart failure therapy in patients with dilated cardiomyopathy","volume":"30","author":"Goebel","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1253\/circj.CJ-07-1087","article-title":"Prognostic implications of the NT-ProBNP level and left atrial size in non-ischemic dilated cardiomyopathy","volume":"72","author":"Kim","year":"2008","journal-title":"Circ. 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Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1161\/01.CIR.0000124723.16433.31","article-title":"Characterization of left ventricular diastolic function by tissue Doppler imaging and clinical status in children with hypertrophic cardiomyopathy","volume":"109","author":"Nagueh","year":"2004","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCIMAGING.108.782086","article-title":"Left ventricular diastolic mechanical dyssynchrony and associated clinical outcomes in children with dilated cardiomyopathy","volume":"1","author":"Friedberg","year":"2008","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2217\/fca.13.66","article-title":"Pediatric Cardiomyopathies: Causes, epidemiology, clinical course, preventive strategies and therapies","volume":"9","author":"Lipshultz","year":"2013","journal-title":"Future Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCIMAGING.114.002120","article-title":"Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children with Idiopathic or Familial Dilated Cardiomyopathy","volume":"7","author":"Mondal","year":"2014","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/HCO.0000000000000346","article-title":"The continuing challenge of evaluating diastolic function by echocardiography in children: Developing concepts and newer modalities","volume":"32","author":"Mawad","year":"2017","journal-title":"Curr. Opin. Cardiol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1500\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:44:40Z","timestamp":1760143480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/10\/1500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["children9101500"],"URL":"https:\/\/doi.org\/10.3390\/children9101500","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}