{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:39:24Z","timestamp":1780605564237,"version":"3.54.1"},"reference-count":110,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Specific University Research provided by M\u0160MT","award":["MUNI\/A\/1166\/2021"],"award-info":[{"award-number":["MUNI\/A\/1166\/2021"]}]},{"name":"Specific University Research provided by M\u0160MT","award":["MUNI\/A\/1178\/2021"],"award-info":[{"award-number":["MUNI\/A\/1178\/2021"]}]},{"name":"Specific University Research provided by M\u0160MT","award":["FNBr,65269705"],"award-info":[{"award-number":["FNBr,65269705"]}]},{"name":"Specific University Research provided by M\u0160MT","award":["NU21-06-00363"],"award-info":[{"award-number":["NU21-06-00363"]}]},{"name":"Specific University Research provided by M\u0160MT","award":["SUp 12\/18"],"award-info":[{"award-number":["SUp 12\/18"]}]},{"name":"MH CZ\u2014DRO","award":["MUNI\/A\/1166\/2021"],"award-info":[{"award-number":["MUNI\/A\/1166\/2021"]}]},{"name":"MH CZ\u2014DRO","award":["MUNI\/A\/1178\/2021"],"award-info":[{"award-number":["MUNI\/A\/1178\/2021"]}]},{"name":"MH CZ\u2014DRO","award":["FNBr,65269705"],"award-info":[{"award-number":["FNBr,65269705"]}]},{"name":"MH CZ\u2014DRO","award":["NU21-06-00363"],"award-info":[{"award-number":["NU21-06-00363"]}]},{"name":"MH CZ\u2014DRO","award":["SUp 12\/18"],"award-info":[{"award-number":["SUp 12\/18"]}]},{"name":"AZV\u2014Czech Health Research Council","award":["MUNI\/A\/1166\/2021"],"award-info":[{"award-number":["MUNI\/A\/1166\/2021"]}]},{"name":"AZV\u2014Czech Health Research Council","award":["MUNI\/A\/1178\/2021"],"award-info":[{"award-number":["MUNI\/A\/1178\/2021"]}]},{"name":"AZV\u2014Czech Health Research Council","award":["FNBr,65269705"],"award-info":[{"award-number":["FNBr,65269705"]}]},{"name":"AZV\u2014Czech Health Research Council","award":["NU21-06-00363"],"award-info":[{"award-number":["NU21-06-00363"]}]},{"name":"AZV\u2014Czech Health Research Council","award":["SUp 12\/18"],"award-info":[{"award-number":["SUp 12\/18"]}]},{"name":"University Hospital Brno","award":["MUNI\/A\/1166\/2021"],"award-info":[{"award-number":["MUNI\/A\/1166\/2021"]}]},{"name":"University Hospital Brno","award":["MUNI\/A\/1178\/2021"],"award-info":[{"award-number":["MUNI\/A\/1178\/2021"]}]},{"name":"University Hospital Brno","award":["FNBr,65269705"],"award-info":[{"award-number":["FNBr,65269705"]}]},{"name":"University Hospital Brno","award":["NU21-06-00363"],"award-info":[{"award-number":["NU21-06-00363"]}]},{"name":"University Hospital Brno","award":["SUp 12\/18"],"award-info":[{"award-number":["SUp 12\/18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Malignant Hyperthermia (MH) is a rare, hereditary, life-threatening disease triggered by volatile anesthetics and succinylcholine. Rarely, MH can occur after non-pharmacological triggers too. MH was detected more often in children and young adults, which makes this topic very important for every pediatric specialist, both anesthesiologists and intensivists. MH crisis is a life-threatening severe hypermetabolic whole-body reaction. Triggers of MH are used in pediatric intensive care unit (PICU) as well, volatile anesthetics in difficult sedation, status asthmaticus or epilepticus, and succinylcholine still sometimes in airway management. Recrudescence or delayed onset of MH crisis hours after anesthesia was previously described. MH can also be a cause of rhabdomyolysis and hyperpyrexia in the PICU. In addition, patients with neuromuscular diseases are often admitted to PICU and they might be at risk for MH. The most typical symptoms of MH are hypercapnia, tachycardia, hyperthermia, and muscle rigidity. Thinking of the MH as the possible cause of deterioration of a patient\u2019s clinical condition is the key to early diagnosis and treatment. The sooner the correct treatment is commenced, the better patient\u00b4s outcome. This narrative review article aims to summarize current knowledge and guidelines about recognition, treatment, and further management of MH in PICU.<\/jats:p>","DOI":"10.3390\/children9111692","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T04:15:23Z","timestamp":1667535323000},"page":"1692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Malignant Hyperthermia in PICU\u2014From Diagnosis to Treatment in the Light of Up-to-Date Knowledge"],"prefix":"10.3390","volume":"9","author":[{"given":"Martina","family":"Klincov\u00e1","sequence":"first","affiliation":[{"name":"Academic Centre for Malignant Hyperthermia, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"\u0160t\u011bp\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Academic Centre for Malignant Hyperthermia, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Schr\u00f6derov\u00e1","sequence":"additional","affiliation":[{"name":"Academic Centre for Malignant Hyperthermia, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Anesthesiology and Intensive Care, St. Anne\u2019s University Hospital and Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-9415","authenticated-orcid":false,"given":"Eva","family":"Klabusayov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"\u0160toura\u010d","sequence":"additional","affiliation":[{"name":"Academic Centre for Malignant Hyperthermia, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"},{"name":"Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13023-015-0310-1","article-title":"Malignant hyperthermia: A review","volume":"10","author":"Rosenberg","year":"2015","journal-title":"Orphanet. J. Rare. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/humu.20356","article-title":"Mutations in RYR1 in malignant hyperthermia and central core disease","volume":"27","author":"Robinson","year":"2006","journal-title":"Hum. Mutat."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Carpenter, D., Ringrose, C., Leo, V., Morris, A., Robinson, R.L., Halsall, P.J., Hopkins, P.M., and Shaw, M.-A. (2009). The role of CACNA1S in predisposition to malignant hyperthermia. BMC Med. Genet., 10.","DOI":"10.1186\/1471-2350-10-104"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/humu.23635","article-title":"STAC3 variants cause a congenital myopathy with distinctive dysmorphic features and malignant hyperthermia susceptibility","volume":"39","author":"Zaharieva","year":"2018","journal-title":"Hum. Mutat."},{"key":"ref_5","unstructured":"European Malignant Hyperthermia Group (2021, December 21). STAC3 Variants in Susceptibility to Malignant Hyperthermia. Available online: https:\/\/www.emhg.org\/stac3."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bja.2018.06.028","article-title":"Genetic epidemiology of malignant hyperthermia in the UK","volume":"121","author":"Miller","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1213\/ANE.0b013e31828a71ff","article-title":"Ryanodine receptor type 1 gene variants in the malignant hyperthermia-susceptible population of the United States","volume":"116","author":"Brandom","year":"2013","journal-title":"Anesth. Analg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s12630-011-9494-6","article-title":"Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population","volume":"58","author":"Kraeva","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0310057X1504300204","article-title":"Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families","volume":"43","author":"Gillies","year":"2015","journal-title":"Anaesth. Intensiv. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/EJA.0000000000001399","article-title":"BMI and malignant hyperthermia pathogenic ryanodine receptor type 1 sequence variants in Switzerland: A retrospective cohort analysis","volume":"38","author":"Gonzalez","year":"2021","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.bja.2022.04.029","article-title":"Malignant hyperthermia in Czechia and Slovakia","volume":"129","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/00000542-200211000-00007","article-title":"Presence of two different genetic traits in malignant hyperthermia families: Implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility","volume":"97","author":"Monnier","year":"2002","journal-title":"Anesthesiology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/ALN.0000000000001878","article-title":"Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept","volume":"128","author":"Riazi","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_14","first-page":"84","article-title":"An update on the malignant hyperthermia syndrome","volume":"23","author":"Rosenberg","year":"1994","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bja.2020.04.089","article-title":"Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines","volume":"125","author":"Glahn","year":"2020","journal-title":"Br. J. Anaesth."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1213\/ANE.0000000000000063","article-title":"DNA testing for malignant hyperthermia: The reality and the dream","volume":"118","author":"Stowell","year":"2014","journal-title":"Anesth. Analg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/anae.15317","article-title":"Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists","volume":"76","author":"Hopkins","year":"2021","journal-title":"Anaesthesia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bja.2020.09.029","article-title":"Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group","volume":"126","author":"Bastian","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1172-9-8","article-title":"Functional and genetic characterization of clinical malignant hyperthermia crises: A multi-centre study","volume":"9","author":"Klingler","year":"2014","journal-title":"Orphanet. J. Rare. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1213\/00000539-199308000-00014","article-title":"Malignant hyperthermia: A review of published cases","volume":"77","author":"Strazis","year":"1993","journal-title":"Anesth. Analg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/ALN.0000000000002813","article-title":"An Assessment of Penetrance and Clinical Expression of Malignant Hyperthermia in Individuals Carrying Diagnostic Ryanodine Receptor 1 Gene Mutations","volume":"131","author":"Hu","year":"2019","journal-title":"Anesthesiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/0310057X1504300415","article-title":"The changing face of malignant hyperthermia: Less fulminant, more insidious","volume":"43","author":"Heytens","year":"2015","journal-title":"Anaesth. Intensive Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/ALN.0000000000004199","article-title":"Referral Indications for Malignant Hyperthermia Susceptibility Diagnostics in Patients without Adverse Anesthetic Events in the Era of Next-generation Sequencing","volume":"136","author":"Hellblom","year":"2022","journal-title":"Anesthesiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12871-021-01328-3","article-title":"Malignant hyperthermia when dantrolene is not readily available","volume":"21","author":"Gong","year":"2021","journal-title":"BMC Anesthesiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/0310057X0203000410","article-title":"Suspected malignant hyperthermia reactions in New Zealand","volume":"30","author":"Pollock","year":"2002","journal-title":"Anaesth. Intensive Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1213\/ANE.0000000000000062","article-title":"Anesthetic drugs and onset of malignant hyperthermia","volume":"118","author":"Visoiu","year":"2014","journal-title":"Anesth. Analg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1034\/j.1399-6576.2000.440320.x","article-title":"Contractures in skeletal muscle of malignant hyperthermia susceptible patients after in vitro exposure to sevoflurane","volume":"44","author":"Snoeck","year":"2000","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/EJA.0b013e32833ed06c","article-title":"In-vitro contracture testing for susceptibility to malignant hyperthermia: Can halothane be replaced?","volume":"28","author":"Metterlein","year":"2011","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/bja\/aer132","article-title":"Malignant hyperthermia: Pharmacology of triggering","volume":"107","author":"Hopkins","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(91)92304-K","article-title":"Evidence for related myopathies in exertional heat stroke and malignant hyperthermia","volume":"338","author":"Hopkins","year":"1991","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/01.pec.0000227388.91885.4b","article-title":"Heatstroke in the super-sized athlete","volume":"22","author":"Fink","year":"2006","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/ALN.0b013e3182320068","article-title":"Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families","volume":"115","author":"Groom","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1213\/ANE.0b013e3182768f99","article-title":"Case report: Death in the emergency department: An unrecognized awake malignant hyperthermia-like reaction in a six-year-old","volume":"116","author":"Lavezzi","year":"2013","journal-title":"Anesth. Analg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/pan.13006","article-title":"Repeated nonanesthetic malignant hyperthermia reactions in a child","volume":"26","author":"Cummings","year":"2016","journal-title":"Paediatr. Anaesth."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0000000000000732","article-title":"Malignant hyperthermia testing in probands without adverse anesthetic reaction","volume":"123","author":"Timmins","year":"2015","journal-title":"Anesthesiology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1016\/j.jemermed.2016.03.002","article-title":"Is It Exertional Heatstroke or Something More? A Case Report","volume":"51","author":"Schlosser","year":"2016","journal-title":"J. Emerg. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s12630-019-01320-z","article-title":"Fatal awake malignant hyperthermia episodes in a family with malignant hyperthermia susceptibility: A case series","volume":"66","author":"Zvaritch","year":"2019","journal-title":"Can. J. Anaesth."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e01377","DOI":"10.1213\/XAA.0000000000001377","article-title":"Episodic RYR1-Related Crisis: Part of the Evolving Spectrum of RYR1-Related Myopathies and Malignant Hyperthermia-Like Illnesses","volume":"15","author":"Dowling","year":"2021","journal-title":"A A Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/bja\/aeq243","article-title":"Recognizing and managing a malignant hyperthermia crisis: Guidelines from the European Malignant Hyperthermia Group","volume":"105","author":"Glahn","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_40","unstructured":"MHAUS (2022, August 03). Managing a Crisis. Available online: https:\/\/www.mhaus.org\/healthcare-professionals\/managing-a-crisis\/."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00000542-199404000-00008","article-title":"A clinical grading scale to predict malignant hyperthermia susceptibility","volume":"80","author":"Larach","year":"1994","journal-title":"Anesthesiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/01.anes.0000265148.86566.68","article-title":"Analysis of the clinical variables associated with recrudescence after malignant hyperthermia reactions","volume":"106","author":"Burkman","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/01.anes.0000265144.63696.af","article-title":"Recrudescence of malignant hyperthermia","volume":"106","author":"Hopkins","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3000605211044201","DOI":"10.1177\/03000605211044201","article-title":"Delayed-onset malignant hyperthermia in the postanesthetic care unit: A case report","volume":"49","author":"Min","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/ALN.0b013e31818958e5","article-title":"Postoperative malignant hyperthermia: An analysis of cases from the North American Malignant Hyperthermia Registry","volume":"109","author":"Litman","year":"2008","journal-title":"Anesthesiology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1213\/01.ANE.0000097172.44227.0D","article-title":"A suspected case of delayed onset malignant hyperthermia with desflurane anesthesia","volume":"98","author":"Papadimos","year":"2004","journal-title":"Anesth. Analg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1460-9592.2009.03120.x","article-title":"Hyperthermia in the pediatric intensive care unit\u2014Is it malignant hyperthermia?","volume":"19","author":"Schleelein","year":"2009","journal-title":"Paediatr. Anaesth."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e051745","DOI":"10.1136\/bmjopen-2021-051745","article-title":"Use of inhalational anaesthetic agents in paediatric and adult patients for status asthmaticus, status epilepticus and difficult sedation scenarios: A protocol for a systematic review","volume":"11","author":"Gorsky","year":"2021","journal-title":"BMJ Open"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/bja\/aet257","article-title":"Sevoflurane therapy for life-threatening asthma in children","volume":"111","author":"Schutte","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/ccr3.1490","article-title":"Sevoflurane improves respiratory mechanics and gas exchange in a case series of infants with severe bronchiolitis-induced acute respiratory distress syndrome","volume":"6","author":"Nacoti","year":"2018","journal-title":"Clin. Case Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/pan.12577","article-title":"Volatile anesthetics for status asthmaticus in pediatric patients: A comprehensive review and case series","volume":"25","author":"Anderson","year":"2015","journal-title":"Paediatr. Anaesth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1097\/PCC.0000000000001538","article-title":"An Exploratory Study of Sevoflurane as an Alternative for Difficult Sedation in Critically Ill Children","volume":"19","author":"Palacios","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12028-021-01250-z","article-title":"Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation","volume":"35","author":"Stetefeld","year":"2021","journal-title":"Neurocrit. Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/cjn.2014.121","article-title":"Modern inhalational anesthetics for refractory status epilepticus","volume":"42","author":"Zeiler","year":"2015","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/epi4.12545","article-title":"Sevoflurane as bridge therapy for plasma exchange and Anakinra in febrile infection-related epilepsy syndrome","volume":"6","author":"Roperto","year":"2021","journal-title":"Epilepsia Open"},{"key":"ref_56","first-page":"e19032","article-title":"Inhalational Anesthesia for Near-fatal Pediatric Asthma Complicated by Malignant Hyperthermia","volume":"13","author":"Pasrija","year":"2021","journal-title":"Cureus"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/ALN.0000000000002490","article-title":"Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review","volume":"130","author":"Larach","year":"2019","journal-title":"Anesthesiology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/00000542-199211000-00040","article-title":"Intractable cardiac arrest in children given succinylcholine","volume":"77","author":"Rosenberg","year":"1992","journal-title":"Anesthesiology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/PCC.0000000000000319","article-title":"Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study","volume":"16","author":"Tarquinio","year":"2015","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/EJA.0000000000001194","article-title":"Rapid sequence induction: An international survey","volume":"37","author":"Klucka","year":"2020","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/PCC.0000000000001397","article-title":"Rhabdomyolysis in a Tertiary PICU: A 10-Year Study","volume":"19","author":"Gelbart","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/01.CSMR.0000313392.79569.e7","article-title":"Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia: Is there a link?","volume":"7","author":"Muldoon","year":"2008","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s40279-020-01318-4","article-title":"Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture","volume":"50","author":"Laitano","year":"2020","journal-title":"Sports Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1381612827666210804095300","article-title":"RYR1-Related Rhabdomyolysis: A Spectrum of Hypermetabolic States Due to Ryanodine Receptor Dysfunction","volume":"28","author":"Kruijt","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s40279-021-01569-9","article-title":"Comment on \u201cOverlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture\"","volume":"52","author":"Kruijt","year":"2022","journal-title":"Sports Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0733-8619(05)70338-8","article-title":"Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome","volume":"15","author":"Bertorini","year":"1997","journal-title":"Neurol. Clin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.emc.2013.07.003","article-title":"Hyperthermia caused by drug interactions and adverse reactions","volume":"31","author":"Paden","year":"2013","journal-title":"Emerg. Med. Clin. N. Am."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9758\/cpn.2021.19.1.1","article-title":"Drug-induced Hyperthermic Syndromes in Psychiatry","volume":"19","author":"Caroff","year":"2021","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.nmd.2020.10.010","article-title":"HyperCKemia and rhabdomyolysis in the neuroleptic malignant and serotonin syndromes: A literature review","volume":"30","author":"Kruijt","year":"2020","journal-title":"Neuromuscul. Disord."},{"key":"ref_70","first-page":"e10635","article-title":"The Genetic Foundations of Serotonin Syndrome, Neuroleptic Malignant Syndrome, and Malignant Hyperthermia: Is There a Genetic Association Between These Disorders?","volume":"12","author":"Ortiz","year":"2020","journal-title":"Cureus"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/PEC.0b013e31826289d9","article-title":"Recognizing serotonin toxicity in the pediatric emergency department","volume":"28","author":"Kant","year":"2012","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_72","unstructured":"(2022, August 21). Picmonic. Malignant Hyperthermia vs. Neuroleptic Malignant Syndrome vs. Serotonin Syndrome. Available online: https:\/\/www.picmonic.com\/learn\/malignant-hyperthermia-vs-neuroleptic-malignant-syndrome-vs-serotonin-syndrome_8256."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/ALN.0000000000001877","article-title":"Malignant Hyperthermia Susceptibility and Related Diseases","volume":"128","author":"Litman","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/ene.12713","article-title":"RYR1-related myopathies: A wide spectrum of phenotypes throughout life","volume":"22","author":"Snoeck","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nmd.2016.02.007","article-title":"Neuromuscular conditions associated with malignant hyperthermia in paediatric patients: A 25-year retrospective study","volume":"26","author":"Bamaga","year":"2016","journal-title":"Neuromuscul. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/EJA.0000000000000672","article-title":"Anaesthetic management of patients with myopathies","volume":"34","author":"Schieren","year":"2017","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_77","unstructured":"(2022, August 04). UpToDate Conditions associated with malignant hyperthermia or rhabdomyolysis. Available online: https:\/\/www.uptodate.com\/contents\/image?imageKey=ANEST%2F65645."},{"key":"ref_78","unstructured":"(2022, August 04). orphanAnaesthesia Rare Diseases. Available online: https:\/\/www.orphananesthesia.eu\/en\/rare-diseases\/published-guidelines.html."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.resuscitation.2021.02.015","article-title":"European Resuscitation Council Guidelines 2021: Paediatric Life Support","volume":"161","author":"Turner","year":"2021","journal-title":"Resuscitation"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.accpm.2017.07.009","article-title":"The use of a checklist improves anaesthesiologists\u2019 technical and non-technical performance for simulated malignant hyperthermia management","volume":"37","author":"Hardy","year":"2018","journal-title":"Anaesth. Crit. Care Pain. Med."},{"key":"ref_81","unstructured":"Klincov\u00e1, M., \u0160t\u011bp\u00e1nkov\u00e1, D., Kostro\u0148ov\u00e1, P., and Kotrhov\u00e1, P. (2022, August 03). Malignant Hyperthermia. Available online: https:\/\/www.akutne.cz\/index-en.php?pg=education--awarded-interactive-algorithms-in-years-2012-2021&tid=453."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.aorn.2013.06.012","article-title":"Malignant hyperthermia crisis: Optimizing patient outcomes through simulation and interdisciplinary collaboration","volume":"99","author":"Cain","year":"2014","journal-title":"AORN J."},{"key":"ref_83","first-page":"292","article-title":"Acquiring skills in malignant hyperthermia crisis management: Comparison of high-fidelity simulation versus computer-based case study","volume":"68","author":"Gonzalez","year":"2018","journal-title":"Braz. J. Anesthesiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/anae.14407","article-title":"The use of charcoal filters in malignant hyperthermia: Have they found their place?","volume":"74","author":"Bilmen","year":"2019","journal-title":"Anaesthesia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/jm00317a011","article-title":"1-[(5-arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants","volume":"10","author":"Snyder","year":"1967","journal-title":"J. Med. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00000542-198204000-00005","article-title":"Dantrolene in human malignant hyperthermia","volume":"56","author":"Kolb","year":"1982","journal-title":"Anesthesiology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF03004694","article-title":"Malignant hyperthermia: A statistical review","volume":"17","author":"Britt","year":"1970","journal-title":"Can. Anaesth. Soc. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0140-6736(98)03078-5","article-title":"Malignant hyperthermia","volume":"352","author":"Denborough","year":"1998","journal-title":"Lancet"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1213\/ANE.0b013e31820b5f1f","article-title":"Complications associated with the administration of dantrolene 1987 to 2006: A report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States","volume":"112","author":"Brandom","year":"2011","journal-title":"Anesth. Analg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jclinane.2013.02.004","article-title":"Upper extremity deep vein thrombosis in a patient treated for malignant hyperthermia","volume":"25","author":"Grodofsky","year":"2013","journal-title":"J. Clin. Anesth."},{"key":"ref_91","unstructured":"(2022, August 04). MHAUS Frequently Asked Questions: Dantrolene. Available online: https:\/\/www.mhaus.org\/faqs\/."},{"key":"ref_92","unstructured":"MHAUS (2022, August 04). How Much Dantrolene Should be Available in Facilities Where Volatile Agents Are Not Available or Administered, and Succinylcholine is Only Stocked on Site for Emergency Purposes?. Available online: https:\/\/www.mhaus.org\/healthcare-professionals\/mhaus-recommendations\/how-much-dantrolene-should-be-available-in-facilities-where-volatile-agents-are-not-available-or-administered-and-succinylcholine-is-only-stocked-on-site-for-emergency-purposes\/."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e1094","DOI":"10.1097\/PCC.0000000000002563","article-title":"Use of a Servo-Controlled Cooling Gel Pad System to Regulate Body Temperature in Critically Ill Children","volume":"21","author":"Manrique","year":"2020","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1097\/PCC.0000000000001813","article-title":"Effectiveness of Two Targeted Temperature Management Methods After Pediatric Postcardiac Arrest: A Multicenter International Study","volume":"20","author":"Yunge","year":"2019","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"25645","DOI":"10.1074\/jbc.M110.104976","article-title":"Store-operated Ca2+ entry in malignant hyperthermia-susceptible human skeletal muscle","volume":"285","author":"Duke","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/PCC.0000000000002851","article-title":"Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control\/Avoidance of Bleeding (TAXI-CAB)","volume":"23","author":"Nellis","year":"2022","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/PCC.0000000000002578","article-title":"Outcome of Early Hemostatic Intervention in Children with Sepsis and Nonovert Disseminated Intravascular Coagulation Admitted to PICU: A Randomized Controlled Trial","volume":"22","author":"Elshinawy","year":"2021","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41591-020-0792-9","article-title":"Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units","volume":"26","author":"Chung","year":"2020","journal-title":"Nat. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1186\/s13054-020-03326-2","article-title":"Recommendations for hemodynamic monitoring for critically ill children-expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)","volume":"24","author":"Singh","year":"2020","journal-title":"Crit. Care"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1097\/PCC.0000000000002873","article-title":"2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients with Consideration of the ICU Environment and Early Mobility","volume":"23","author":"Smith","year":"2022","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1365-2044.1996.tb14965.x","article-title":"Serum and urinary myoglobin following an aborted malignant hyperthermia reaction","volume":"51","author":"Laurence","year":"1996","journal-title":"Anaesthesia"},{"key":"ref_102","unstructured":"(2022, August 01). Contact MHAUS. Available online: https:\/\/my.mhaus.org\/page\/contactmhaus."},{"key":"ref_103","unstructured":"MH Units (2022, August 01). EMHG. Available online: https:\/\/www.emhg.org\/mh-units-map."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"The European Malignant Hyperpyrexia Group (1984). A protocol for the investigation of malignant hyperpyrexia (MH) susceptibility. Br. J. Anaesth., 56, 1267\u20131269.","DOI":"10.1093\/bja\/56.11.1267"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/bja\/aev225","article-title":"European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility","volume":"115","author":"Hopkins","year":"2015","journal-title":"Br. J. Anaesth."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"ref_107","unstructured":"(2021, December 21). European Malignant Hyperthermia Group Scoring Matrix for Classification of Genetic Variants in Malignant Hyperthermia Susceptibility. Available online: https:\/\/www.emhg.org\/genetic-scoring-matrix."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/s41436-021-01125-w","article-title":"Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility","volume":"23","author":"Johnston","year":"2021","journal-title":"Genet. Med."},{"key":"ref_109","unstructured":"(2022, August 01). European Malignant Hyperthermia Group Diagnostic MH Mutations. Available online: https:\/\/www.emhg.org\/diagnostic-mutations."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1399-6576.1997.tb04820.x","article-title":"In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: Results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group","volume":"41","author":"Ording","year":"1997","journal-title":"Acta Anaesthesiol. Scand."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/11\/1692\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:10:27Z","timestamp":1760145027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/11\/1692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":110,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["children9111692"],"URL":"https:\/\/doi.org\/10.3390\/children9111692","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]}}}