{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:11:20Z","timestamp":1790115080740,"version":"4.0.1"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: We evaluated the efficacy of Cord Blood Platelet Gel (CBPG) in the regenerative reconstruction of the nasal septal tissue of a preterm infant undergoing non-invasive ventilation. Methods: A CBPC treatment was used to enhance the regeneration of the nasal septum of a premature patient in an experimental way, evaluating the efficacy described in the literature (selective bibliographic search in PubMed) of the use of blood products for non-transfusion purposes. Results: A partial but satisfactory regeneration of the patient\u2019s nasal septum was observed. Using the free NIH Image J online software, we were able to calculate the regenerated surface (about 83% of the destroyed cartilage). Conclusions: The use of platelet gel has been a promising alternative to surgical treatment in patients with severe damage to the nasal septum.<\/jats:p>","DOI":"10.3390\/children9111767","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:35:23Z","timestamp":1668742523000},"page":"1767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impressive Nasal Septum Regeneration after Cord Blood Platelet Gel (CBPG) in Extreme Premature Neonate with Non-Invasive Ventilation: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-3506","authenticated-orcid":false,"given":"Raffaele","family":"Falsaperla","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, AUO Policlinico \u201cRodolico-San Marco\u201d, University of Catania, 95121 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Marialidia","family":"Biondi","sequence":"additional","affiliation":[{"name":"Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Motta","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AUO Policlinico \u201cRodolico-San Marco\u201d, University of Catania, 95121 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Gallerano","sequence":"additional","affiliation":[{"name":"Transfusional Medicine, Complex Operative Unit, PO \u201cGiovanni Paolo II\u201d, 92019 Sciacca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Tancredi","sequence":"additional","affiliation":[{"name":"Transfusional Medicine, Complex Operative Unit, PO \u201cGiovanni Paolo II\u201d, 92019 Sciacca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-9560","authenticated-orcid":false,"given":"Piero","family":"Pavone","sequence":"additional","affiliation":[{"name":"Section of Pediatrics and Child Neuropsichiatry, Department of Child and Experimental Medicine, University of Catania, AOU \u201cPoliclinico PO\u201d G. Rodolico, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsichiatry, University of Catania, AOU \u201cPoliclinico PO\u201d G. Rodolico, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"ref_1","first-page":"e17790","article-title":"Evaluation of the Mortality and Morbidity of Premature Infants During a Five-Year Period in the Neonatal Intensive Care Unit","volume":"13","year":"2021","journal-title":"Cureus"},{"key":"ref_2","first-page":"177","article-title":"Non-Invasive Ventilation in Neonatology","volume":"116","author":"Behnke","year":"2019","journal-title":"Dtsch Arztebl Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/bja\/aet070","article-title":"Complications of non-invasive ventilation techniques: A comprehensive qualitative review of randomized trials","volume":"110","author":"Carron","year":"2013","journal-title":"Br. J. 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Ed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"812038","DOI":"10.3389\/fcell.2021.812038","article-title":"Recycling Apparent Waste onto Biologicals: The Case of Umbilical Cord Blood in Italy and Spain","volume":"9","author":"Rebulla","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_13","first-page":"73","article-title":"Multicentre standardisation of a clinical grade procedure for the preparation of allogeneic platelet concentrates from umbilical cord blood","volume":"14","author":"Rebulla","year":"2015","journal-title":"Blood Transfus."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ferrario, S., Zorz, A., Sorrentino, G., Villa, S., Cavalli, R., Mosca, F., Plevani, L., and Ghirardello, S. (2021). Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases. 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