{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:22:42Z","timestamp":1790774562728,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>This is the first nationwide study aimed to evaluate in-hospital mortality and comorbidities of extremely low birth weight (ELBW) infants in Thailand between 2015\u20132020. Data of ELBW infants were collected from the National Health Coverage Scheme. The incidence of ELBW Thai infants was 1.75 per 1000 live births. Sixty-five percent of ELBW infants were delivered in tertiary-care facilities, with 63% surviving until discharge. In-hospital mortality was 36.9%. Non-invasive respiratory supports were documented in just 17.6% of the study population, whereas total parenteral nutrition was used in 52.3% of neonates. There were several comorbidities, with the three most frequent including respiratory distress syndrome (70.7%), neonatal jaundice (66.7%), and sepsis (60.4%). The median hospitalization cost for one ELBW infant who survived was 296,438.40 baht ($8719). Conclusion: Thailand had an acceptable ELBW infant survival rate (63%), but comorbidities remained particularly severe and cost one hundred times the median hospital cost for one ELBW infant that survived in comparison to a normal newborn infant. Better health outcomes require strategies to raise awareness of the issues and the appropriate implementation of evidence-based solutions, particularly improving neonatal care facilities, as well as early referral of high-risk pregnant women and neonates, which will aid in the future reduction of neonatal morbidities and mortalities.<\/jats:p>","DOI":"10.3390\/children9121825","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T03:28:49Z","timestamp":1669606129000},"page":"1825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mortality and Comorbidities in Extremely Low Birth Weight Thai Infants: A Nationwide Data Analysis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-7253","authenticated-orcid":false,"given":"Pakaphan","family":"Kiatchoosakun","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Jirapradittha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-4312","authenticated-orcid":false,"given":"Pongsatorn","family":"Paopongsawan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-6792","authenticated-orcid":false,"given":"Leelawadee","family":"Techasatian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pagakrong","family":"Lumbiganon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaewjai","family":"Thepsuthammarat","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitr","family":"Sutra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","first-page":"S17","article-title":"Current Challenges in Reducing Neonatal Morbidity and Mortality in Thailand","volume":"95","author":"Kiatchoosakun","year":"2012","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Oestergaard, M.Z., Inoue, M., Yoshida, S., Mahanani, W.R., Gore, F.M., Cousens, S., Lawn, J.E., Mathers, C.D., and United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group (2011). Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities. PLoS Med., 8.","DOI":"10.1371\/journal.pmed.1001080"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 Million Neonatal Deaths: When? Where? Why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet Lond. Engl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e710","DOI":"10.1016\/S2214-109X(19)30163-9","article-title":"National, Regional, and Global Levels and Trends in Neonatal Mortality between 1990 and 2017, with Scenario-Based Projections to 2030: A Systematic Analysis","volume":"7","author":"Hug","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0140-6736(10)62049-1","article-title":"Maternal, Neonatal, and Child Health in Southeast Asia: Towards Greater Regional Collaboration","volume":"377","author":"Acuin","year":"2011","journal-title":"Lancet Lond. Engl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e196294","DOI":"10.1001\/jamapediatrics.2019.6294","article-title":"Assessment of an Updated Neonatal Research Network Extremely Preterm Birth Outcome Model in the Vermont Oxford Network","volume":"174","author":"Rysavy","year":"2020","journal-title":"JAMA Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1542\/peds.2011-3028","article-title":"Mortality and Neonatal Morbidity among Infants 501 to 1500 Grams from 2000 to 2009","volume":"129","author":"Horbar","year":"2012","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/jama.2015.10244","article-title":"Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993\u20132012","volume":"314","author":"Stoll","year":"2015","journal-title":"JAMA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1542\/peds.2008-0763","article-title":"Mortality Rates for Extremely Low Birth Weight Infants Born in Japan in 2005","volume":"123","author":"Itabashi","year":"2009","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"873563","DOI":"10.1155\/2013\/873563","article-title":"Survival Rate of Extremely Low Birth Weight Infants and Its Risk Factors: Case-Control Study in Japan","volume":"2013","author":"Ogawa","year":"2013","journal-title":"ISRN Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.2006-1472","article-title":"No Improvement in Outcome of Nationwide Extremely Low Birth Weight Infant Populations between 1996\u20131997 and 1999\u20132000","volume":"119","author":"Tommiska","year":"2007","journal-title":"Pediatrics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e957","DOI":"10.1542\/peds.2012-0336","article-title":"Comparison of Mortality and Morbidity of Very Low Birth Weight Infants between Canada and Japan","volume":"130","author":"Isayama","year":"2012","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1542\/peds.113.4.781","article-title":"Center Differences and Outcomes of Extremely Low Birth Weight Infants","volume":"113","author":"Vohr","year":"2004","journal-title":"Pediatrics"},{"key":"ref_14","first-page":"743","article-title":"Outcome of Extremely Low Birth Weight (ELBW) Infants from a Birth Cohort (2013\u20132018) in a Tertiary Care Unit in North India","volume":"40","author":"Sahoo","year":"2020","journal-title":"J. Perinatol. Off. J. Calif. Perinat. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11119","DOI":"10.1038\/s41598-022-14432-2","article-title":"Short Term Outcomes of Extremely Low Birth Weight Infants from a Multicenter Cohort Study in Guangdong of China","volume":"12","author":"Jia","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12978-020-01026-2","article-title":"Regional Trends in Birth Weight in Low- and Middle-Income Countries 2013\u20132018","volume":"17","author":"Marete","year":"2020","journal-title":"Reprod. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/jpc.14782","article-title":"Outcomes of Preterm Infants Born with Marginal Viability in a University Hospital in Thailand","volume":"56","author":"Piriyapokin","year":"2020","journal-title":"J. Paediatr. Child Health"},{"key":"ref_18","first-page":"191","article-title":"Outcomes of Very Low Birth Weight Infants in Songklanagarind Hospital","volume":"93","author":"Chanvitan","year":"2010","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_19","first-page":"1323","article-title":"Survival and Outcome of Very Low Birth Weight Infants Born in a University Hospital with Level II NICU","volume":"90","author":"Sritipsukho","year":"2007","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_20","unstructured":"(2020). Number of Total Livebirths and Livebirths in Hospital and Percentage of Livebirths in Hospital per Total Livebirths by Region and Province, 2015\u20142019, Ministry of Public Health."},{"key":"ref_21","first-page":"CD001243","article-title":"Prophylactic Nasal Continuous Positive Airway Pressure for Preventing Morbidity and Mortality in Very Preterm Infants","volume":"14","author":"Subramaniam","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal Necrotizing Enterocolitis. Therapeutic Decisions Based upon Clinical Staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and Evolution of Subependymal and Intraventricular Hemorrhage: A Study of Infants with Birth Weights Less than 1,500 Gm","volume":"92","author":"Papile","year":"1978","journal-title":"J. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1515\/jpm-2020-0331","article-title":"Global Incidence of Intraventricular Hemorrhage among Extremely Preterm Infants: A Systematic Literature Review","volume":"49","author":"Siffel","year":"2021","journal-title":"J. Perinat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e20183061","DOI":"10.1542\/peds.2018-3061","article-title":"Screening Examination of Premature Infants for Retinopathy of Prematurity","volume":"142","author":"Fierson","year":"2018","journal-title":"Pediatrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.siny.2016.08.002","article-title":"Total Parenteral Nutrition for the Very Low Birth Weight Infant","volume":"22","author":"Patel","year":"2017","journal-title":"Semin. Fetal. Neonatal Med."},{"key":"ref_27","first-page":"88","article-title":"Effects of Red Blood Cell Transfusions on the Risk of Developing Complications or Death: An Observational Study of a Cohort of Very Low Birth Weight Infants","volume":"34","author":"Ghirardello","year":"2017","journal-title":"Am. J. Perinatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/trf.12998","article-title":"Canadian Neonatal Network Temporal Changes in Blood Product Usage in Preterm Neonates Born at Less than 30 Weeks\u2019 Gestation in Canada","volume":"55","author":"Keir","year":"2015","journal-title":"Transfusion"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S524","DOI":"10.1161\/CIR.0000000000000902","article-title":"Part 5: Neonatal Resuscitation: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"142","author":"Aziz","year":"2020","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000499361","article-title":"European Consensus Guidelines on the Management of Respiratory Distress Syndrome\u20142019 Update","volume":"115","author":"Sweet","year":"2019","journal-title":"Neonatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.7196\/sajch.488","article-title":"Survival of Extremely Low-Birth-Weight Infants","volume":"7","author":"Kalimba","year":"2013","journal-title":"S. Afr. J. Child Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0140-6736(14)60792-3","article-title":"Can Available Interventions End Preventable Deaths in Mothers, Newborn Babies, and Stillbirths, and at What Cost?","volume":"384","author":"Bhutta","year":"2014","journal-title":"Lancet Lond. Engl."},{"key":"ref_33","first-page":"CD007754","article-title":"Community-Based Intervention Packages for Reducing Maternal and Neonatal Morbidity and Mortality and Improving Neonatal Outcomes","volume":"23","author":"Lassi","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/jama.2010.1226","article-title":"Perinatal Regionalization for Very Low-Birth-Weight and Very Preterm Infants: A Meta-Analysis","volume":"304","author":"Lasswell","year":"2010","journal-title":"JAMA"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/12\/1825\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:27:05Z","timestamp":1760146025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/12\/1825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["children9121825"],"URL":"https:\/\/doi.org\/10.3390\/children9121825","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]}}}