{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:56:22Z","timestamp":1794005782002,"version":"4.8.0"},"reference-count":146,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>OFCs (orofacial clefts) are among the most frequent congenital defects, but their etiology has yet to be clarified. OFCs affect different structures and functions with social, psychological and economic implications in children and their families. Identifying modifiable risk factors is mandatory to prevent the occurrence of non-syndromic OFCs (NSOFCs). PubMed, Cochrane Library, Scopus and Web of Science were searched from 1 January 2012 to 25 May 2022 and a total of 7668 publications were identified. Studies focusing on the risk factors of NSOFCs were selected, leading to 62 case-control and randomized clinical trials. Risk factors were categorized into non-modifiable and modifiable. The first group includes genetic polymorphisms, gender of the newborn, ethnicity, and familiarity. Within the second group, risk factors that can only be modified before conception (consanguinity, parental age at conception, socio-economical and educational level, area of residency and climate), and risk factors modifiable before and after conception (weight, nutritional state, acute and chronic diseases, psychophysical stress, licit and illicit drugs, alcohol, smoke, pollutants and contaminants) have been distinguished. This study provides a wide overview of the risk factors of NSOFCs, focusing on modifiable ones, to suggest new perspectives in education, prevention, medical interventions and clinical research.<\/jats:p>","DOI":"10.3390\/children9121846","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:38:49Z","timestamp":1669621129000},"page":"1846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-6337","authenticated-orcid":false,"given":"Angelo Michele","family":"Inchingolo","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-8179","authenticated-orcid":false,"given":"Maria Celeste","family":"Fatone","sequence":"additional","affiliation":[{"name":"PTA Trani-ASL BT, Viale Padre Pio, 76125 Trani, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-7506","authenticated-orcid":false,"given":"Giuseppina","family":"Malcangi","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Avantario","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, University of Bari \u201cAldo Moro\u201d, 70124 Bari, 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Epigenet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1601-0825.2009.01588.x","article-title":"The Impact of Orofacial Clefts on Quality of Life and Health Care Use and Costs","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft Lip and Palate: Understanding Genetic and Environmental Influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_4","first-page":"141","article-title":"Three-Dimensional Analysis of Facial Morphology: Growth, Development and Aging of the Orolabial Region","volume":"115","author":"Sforza","year":"2010","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Berkowitz, S. (2006). Characteristics of facial morphology and growth in infants with clefts. Cleft Lip and Palate, Springer.","DOI":"10.1007\/3-540-30020-1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft Lip and Palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"ref_7","unstructured":"Mcbride, W.A., Mcintyre, G.T., Carroll, K., and Mossey, P.A. (2022, October 03). Subphenotyping and Classification of Orofacial Clefts: Need for Orofacial Cleft Subphenotyping Calls for Revised Classification. Available online: https:\/\/journals.sagepub.com\/doi\/10.1597\/15-029?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Houkes, R., Smit, J., Mossey, P., Don Griot, P., Persson, M., Neville, A., Ongkosuwito, E., Sitzman, T., and Breugem, C. (2021). Classification Systems of Cleft Lip, Alveolus and Palate: Results of an International Survey. Cleft Palate Craniofac. J., 105566562110573.","DOI":"10.1177\/10556656211057368"},{"key":"ref_9","first-page":"103","article-title":"Epidemiology of Cleft Lip and Palate. An Attempt to Rule out Chance Correlations","volume":"29","year":"1975","journal-title":"Br. J. Prev. Soc. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hlongwa, P., Levin, J., and Rispel, L.C. (2019). Epidemiology and Clinical Profile of Individuals with Cleft Lip and Palate Utilising Specialised Academic Treatment Centres in South Africa. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215931"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000337617","article-title":"Roles of BMP Signaling Pathway in Lip and Palate Development","volume":"16","author":"Parada","year":"2012","journal-title":"Front. Oral Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1093\/hmg\/ddh052","article-title":"Genetics of Cleft Lip and Palate: Syndromic Genes Contribute to the Incidence of Non-Syndromic Clefts","volume":"13","author":"Stanier","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"ref_13","first-page":"336","article-title":"The Genetics of Cleft Lip and Cleft Palate","volume":"22","author":"Fraser","year":"1970","journal-title":"Am. J. Hum. Genet."},{"key":"ref_14","first-page":"323","article-title":"Mode of Inheritance of Nonsyndromic Cleft Lip with or without Cleft Palate: A Reanalysis","volume":"51","author":"Mitchell","year":"1992","journal-title":"Am. J. Hum. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/aje\/kwi214","article-title":"Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?","volume":"162","author":"Harville","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1597\/07-134.1","article-title":"DNA Methylation Changes during Cleft Palate Formation Induced by Retinoic Acid in Mice","volume":"45","author":"Kuriyama","year":"2008","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4103\/0971-6866.107973","article-title":"Small Players with a Big Role: MicroRNAs in Pathophysiology of Cleft Lip and Palate","volume":"18","author":"Radhakrishna","year":"2012","journal-title":"Indian J. Hum. Genet."},{"key":"ref_18","first-page":"e1118","article-title":"Clinical and Epidemiological Profile of Cleft Lip and Palate Patients in Peru, 2006\u20132019","volume":"13","year":"2021","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.30699\/mmlj17.4.2.40","article-title":"Evaluation of the Correlation between Socioeconomic Factors and Pediatric Cleft Lip and Palate","volume":"4","author":"Habibi","year":"2021","journal-title":"Mod. Med. Lab. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1399-0004.2002.610402.x","article-title":"Gene\/Environment Causes of Cleft Lip and\/or Palate","volume":"61","author":"Murray","year":"2002","journal-title":"Clin. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/bdra.20342","article-title":"Maternal Flu or Fever, Medication Use, and Neural Tube Defects: A Population-Based Case-Control Study in Northern China","volume":"79","author":"Li","year":"2007","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1601-0825.2011.01810.x","article-title":"Maternal Malnutrition, Environmental Exposure during Pregnancy and the Risk of Non-Syndromic Orofacial Clefts","volume":"17","author":"Jia","year":"2011","journal-title":"Oral Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/ams.ams_134_20","article-title":"Parental Age and the Risk of Cleft Lip and Palate in a Nigerian Population\u2014A Case\u2013Control Study","volume":"10","author":"James","year":"2020","journal-title":"Ann. Maxillofac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.annepidem.2015.05.003","article-title":"Parental Age and the Risk of Isolated Cleft Lip: A Registry-Based Study","volume":"25","author":"Berg","year":"2015","journal-title":"Ann. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.20396\/bjos.v15i2.8648758","article-title":"Parental Age Is Related to the Occurrence of Cleft Lip and Palate in Brazilian Populations","volume":"15","author":"Machado","year":"2017","journal-title":"Braz. J. Oral Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00001648-200011000-00013","article-title":"A Prospective Study of the Risk of Congenital Defects Associated with Maternal Obesity and Diabetes Mellitus","volume":"11","author":"Moore","year":"2000","journal-title":"Epidemiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00000637-200111000-00001","article-title":"Association between Maternal Diabetes Mellitus and Newborn Oral Cleft","volume":"47","author":"Spilson","year":"2001","journal-title":"Ann. Plast. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.sap.0000221623.15710.b9","article-title":"Clinical and Epidemiologic Studies of Nonsyndromic Cleft Lip and Palate in China: Analysis of 4268 Cases","volume":"57","author":"Meng","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/cga.12074","article-title":"Higher Risk of Orofacial Clefts in Children Born to Mothers with Angina Pectoris: A Population-Based Case-Control Study","volume":"55","author":"Czeizel","year":"2015","journal-title":"Congenit. Anom."},{"key":"ref_30","first-page":"190","article-title":"Maternal Underweight and Obesity and Risk of Orofacial Clefts in a Large International Consortium of Population-Based Studies","volume":"46","author":"Kutbi","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_31","first-page":"e2701","article-title":"Diabetes Mellitus and Drug Abuse during Pregnancy and the Risk for Orofacial Clefts and Related Abnormalities","volume":"24","author":"Pimenta","year":"2016","journal-title":"Rev. Lat. Am. Enferm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/bdr2.1073","article-title":"Risk Factors for Orofacial Clefts in India: A Case\u2013Control Study","volume":"109","author":"Neogi","year":"2017","journal-title":"Birth Defects Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/bdra.23133","article-title":"Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis: Folic Acid Supplementation and MTHFR C677T Polymorphism in OFC","volume":"97","author":"Butali","year":"2013","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e07957","DOI":"10.1016\/j.heliyon.2021.e07957","article-title":"Distribution and Risk Factors of Cleft Lip and Palate on Patients from a Sample of Damascus Hospitals\u2014A Case-Control Study","volume":"7","author":"Nahas","year":"2021","journal-title":"Heliyon"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10654-013-9849-0","article-title":"Periconceptional Folic Acid Associated with an Increased Risk of Oral Clefts Relative to Non-Folate Related Malformations in the Northern Netherlands: A Population Based Case-Control Study","volume":"28","author":"Rozendaal","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/ije\/dyn098","article-title":"Folate Intake, Markers of Folate Status and Oral Clefts: Is the Evidence Converging?","volume":"37","author":"Johnson","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"ref_37","first-page":"9","article-title":"Parental Cigarette Smoking, Transforming Growth Factor-alpha Gene Variant and the Risk of Orofacial Cleft in Iranian Infants","volume":"19","author":"Ebadifar","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/aje\/kwv279","article-title":"Passive Smoke Exposure as a Risk Factor for Oral Clefts\u2014A Large International Population-Based Study","volume":"183","author":"Kummet","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"ref_39","first-page":"213","article-title":"Tobacco Smoking and Oral Clefts: A Meta-Analysis","volume":"82","author":"Little","year":"2004","journal-title":"Bull. World Health Organ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2105\/AJPH.90.3.415","article-title":"Tobacco and Alcohol Use during Pregnancy and Risk of Oral Clefts. Occupational Exposure and Congenital Malformation Working Group","volume":"90","author":"Lorente","year":"2000","journal-title":"Am. J. Public Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.1.06374","article-title":"Chronic Maternal Stress Inhibits the Capacity to Up-Regulate Placental 11beta-Hydroxysteroid Dehydrogenase Type 2 Activity","volume":"186","author":"Welberg","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.psyneuen.2011.09.014","article-title":"Maternal Prenatal Anxiety and Downregulation of Placental 11\u03b2-HSD2","volume":"37","author":"Freeman","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Jiang, W., Xie, W., Ni, B., Zhou, H., Liu, Z., and Li, X. (2021). First Trimester Exposure to Ambient Gaseous Air Pollutants and Risk of Orofacial Clefts: A Case\u2013Control Study in Changsha, China. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01876-7"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.envres.2015.06.002","article-title":"Maternal Ambient Air Pollution Exposure Preconception and during Early Gestation and Offspring Congenital Orofacial Defects","volume":"140","author":"Zhu","year":"2015","journal-title":"Environ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.envres.2016.11.007","article-title":"Maternal Exposure to Ozone and PM2.5 and the Prevalence of Orofacial Clefts in Four U.S. States","volume":"153","author":"Zhou","year":"2017","journal-title":"Environ. Res."},{"key":"ref_46","first-page":"578","article-title":"Analysis of Environmental Exposures for Nonsyndromic Cleft Lip and\/or Palate: A Case-Control Study","volume":"51","author":"Hsieh","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40902-020-00270-7","article-title":"Assessment of the Correlation between Various Risk Factors and Orofacial Cleft Disorder Spectrum: A Retrospective Case-Control Study","volume":"42","author":"Cheshmi","year":"2020","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/bdr2.1192","article-title":"Maternal Exposures and Risk of Oral Clefts in South Vietnam","volume":"110","author":"Dien","year":"2018","journal-title":"Birth Defects Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1590\/1806-93042019000400012","article-title":"Factors Associated with the Presence of Cleft Lip and\/or Cleft Palate in Brazilian Newborns","volume":"19","author":"Shibukawa","year":"2019","journal-title":"Rev. Bras. Saude Mater. Infant."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lei, R.-L., Chen, H.-S., Huang, B.-Y., Chen, Y.-C., Chen, P.K.-T., Lee, H.-Y., Chang, C.-W., and Wu, C.-L. (2013). Population-Based Study of Birth Prevalence and Factors Associated with Cleft Lip and\/or Palate in Taiwan 2002\u20132009. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058690"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1921036","DOI":"10.1001\/jamanetworkopen.2019.21036","article-title":"Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada","volume":"3","author":"Malic","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/bdra.23417","article-title":"Parental Risk Factors for Oral Clefts among Central Africans, Southeast Asians, and Central Americans","volume":"103","author":"Figueiredo","year":"2015","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.9738\/INTSURG-D-13-00089.1","article-title":"Analysis of Potential Oral Cleft Risk Factors in the Kosovo Population","volume":"99","author":"Salihu","year":"2014","journal-title":"Int. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/ppe.12727","article-title":"Risk of Non-syndromic Orofacial Clefts by Maternal Rural-urban Residence and Race\/Ethnicity: A Population-based Case-control Study in Washington State 1989\u20132014","volume":"35","author":"Kapos","year":"2021","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_55","first-page":"e24","article-title":"Risk Factors and Comorbidities in Brazilian Patients with Orofacial Clefts","volume":"32","author":"Arruda","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ly, S., Burg, M., Ihenacho, U., Brindopke, F., Auslander, A., Magee, K., Sanchez-Lara, P., Nguyen, T.-H.-D., Nguyen, V., and Tangco, M. (2017). Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14060657"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4103\/0189-6725.172576","article-title":"Cleft Lip and Palate and Related Factors: A 10 Years Study in University Hospitalised Patients at Mashhad\u2014Iran","volume":"12","author":"Noorollahian","year":"2015","journal-title":"Afr. J. Paediatr. Surg."},{"key":"ref_58","first-page":"248","article-title":"Prevalence and Risk Factors of Consanguineous Marriage","volume":"11","author":"Heidari","year":"2014","journal-title":"Eur. J. Gen. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/ajmg.a.34036","article-title":"Genetic Contribution for Non-Syndromic Cleft Lip with or without Cleft Palate (NS CL\/P) in Different Regions of Brazil and Implications for Association Studies","volume":"155","author":"Brito","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e898","DOI":"10.4317\/medoral.15.e898","article-title":"Analysis of Familial Incidence of Non-Syndromic Cleft Lip and Palate in a Brazilian Population","volume":"15","author":"Martelli","year":"2010","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/aje\/kwm283","article-title":"Socioeconomic Status in Relation to Selected Birth Defects in a Large Multicentered US Case-Control Study","volume":"167","author":"Yang","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.2105\/AJPH.2015.302804","article-title":"Neighborhood-Based Socioeconomic Position and Risk of Oral Clefts Among Offspring","volume":"105","author":"Lupo","year":"2015","journal-title":"Am. J. Public Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1754-4505.1994.tb01072.x","article-title":"Birth Prevalence of Cleft Lip and Palate in Colorado by Sex Distribution, Seasonality, Race\/Ethnicity, and Geographic Variation","volume":"14","author":"Amidei","year":"1994","journal-title":"Spec. Care Dent."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/09603123.2014.883593","article-title":"Spatial and Temporal Clustering of Isolated Cleft Lip with or without Cleft Palate in Poland","volume":"24","author":"Walencka","year":"2014","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_65","first-page":"213","article-title":"Cleft lip and palate: Case-control study","volume":"28","author":"Yunes","year":"1994","journal-title":"Rev. Saude Publica"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.annepidem.2009.09.006","article-title":"Urban-Rural Residence and the Occurrence of Cleft Lip and Cleft Palate in Texas, 1999\u20132003","volume":"20","author":"Messer","year":"2010","journal-title":"Ann. Epidemiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/oxfordjournals.aje.a117243","article-title":"Maternal Flu, Fever, and the Risk of Neural Tube Defects: A Population-Based Case-Control Study","volume":"140","author":"Lynberg","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/bdra.20077","article-title":"The Effect of Fever, Febrile Illnesses, and Heat Exposures on the Risk of Neural Tube Defects in a Texas-Mexico Border Population","volume":"70","author":"Suarez","year":"2004","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/bdr2.1385","article-title":"A Population-based Case\u2013Control Study of the Association between Weather-related Extreme Heat Events and Orofacial Clefts","volume":"110","author":"Soim","year":"2018","journal-title":"Birth Defects Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrendo.2012.199","article-title":"Global Obesity: Trends, Risk Factors and Policy Implications","volume":"9","author":"Malik","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2009.113","article-title":"Maternal Overweight and Obesity and the Risk of Congenital Anomalies: A Systematic Review and Meta-Analysis","volume":"301","author":"Stothard","year":"2009","journal-title":"JAMA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"237.e1","DOI":"10.1016\/j.ajog.2008.06.028","article-title":"Diabetes Mellitus and Birth Defects","volume":"199","author":"Correa","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.nutr.24.012003.132249","article-title":"Maternal Obesity, Metabolism, and Pregnancy Outcomes","volume":"26","author":"King","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.bjoms.2015.05.017","article-title":"Maternal Obesity Is a Risk Factor for Orofacial Clefts: A Meta-Analysis","volume":"53","author":"Blanco","year":"2015","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5037\/jomr.2015.6101","article-title":"What Is the Risk of Having Offspring with Cleft Lip\/Palate in Pre-Maternal Obese\/Overweight Women When Compared to Pre-Maternal Normal Weight Women? A Systematic Review and Meta-Analysis","volume":"6","author":"Izedonmwen","year":"2015","journal-title":"J. Oral Maxillofac. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2188\/jea.JE20190347","article-title":"Population Attributable Fractions of Modifiable Risk Factors for Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children\u2019s Study","volume":"31","author":"Sato","year":"2021","journal-title":"J. Epidemiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/archpedi.161.8.745","article-title":"Prepregnancy Obesity as a Risk Factor for Structural Birth Defects","volume":"161","author":"Waller","year":"2007","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/ijo.2010.66","article-title":"Maternal Body Mass Index and Congenital Anomaly Risk: A Cohort Study","volume":"34","author":"Rankin","year":"2010","journal-title":"Int. J. Obes."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.annepidem.2016.11.009","article-title":"Interaction between Smoking and Body Mass Index and Risk of Oral Clefts","volume":"27","author":"Wehby","year":"2017","journal-title":"Ann. Epidemiol."},{"key":"ref_80","first-page":"790","article-title":"Body Mass Index Modulates Aromatic DNA Adduct Levels and Their Persistence in Smokers","volume":"11","author":"Godschalk","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/ocr.12361","article-title":"Maternal-Related Factors in the Origin of Isolated Cleft Palate-A Population-Based Case-Control Study","volume":"23","author":"Nemes","year":"2020","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1177\/0022034513507452","article-title":"Micronutrients and Oral Clefts: A Case-Control Study","volume":"92","author":"McKinney","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12937-018-0420-4","article-title":"Maternal Periconceptional Consumption of Sprouted Potato and Risks of Neural Tube Defects and Orofacial Clefts","volume":"17","author":"Ni","year":"2018","journal-title":"Nutr. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.ede.0000259986.85239.87","article-title":"Maternal Stressful Life Events and Risks of Birth Defects","volume":"18","author":"Carmichael","year":"2007","journal-title":"Epidemiology"},{"key":"ref_85","first-page":"99","article-title":"Corticosteroid Teratogenicity","volume":"27","author":"Rowland","year":"1983","journal-title":"Adv. Vet. Sci. Comp. Med."},{"key":"ref_86","first-page":"50","article-title":"Imprinted Genes, Placental Development and Fetal Growth","volume":"65","author":"Fowden","year":"2006","journal-title":"Horm. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/humrep\/des434","article-title":"Maternal Bereavement in the Antenatal Period and Oral Cleft in the Offspring","volume":"28","author":"Ingstrup","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/cs0960513","article-title":"Glucocorticoids and Insulin Resistance: Old Hormones, New Targets","volume":"96","author":"Andrews","year":"1999","journal-title":"Clin. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/tera.1420260306","article-title":"Vitamin B6 Reduces Cortisone-Induced Cleft Palate in the Mouse","volume":"26","author":"Yoneda","year":"1982","journal-title":"Teratology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1037\/0033-2909.100.3.331","article-title":"Stress, Anxiety, and Birth Outcomes: A Critical Review of the Evidence","volume":"100","author":"Istvan","year":"1986","journal-title":"Psychol. Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dev.103.Supplement.213","article-title":"Teratogens and Craniofacial Malformations: Relationships to Cell Death","volume":"103","author":"Sulik","year":"1988","journal-title":"Development"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1440-1819.2011.02236.x","article-title":"Screening Performance of K6\/K10 and Other Screening Instruments for Mood and Anxiety Disorders in Japan","volume":"65","author":"Sakurai","year":"2011","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/mpr.257","article-title":"The Performance of the Japanese Version of the K6 and K10 in the World Mental Health Survey Japan","volume":"17","author":"Furukawa","year":"2008","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/ajim.22731","article-title":"Maternal Occupational Physical Activity and Risk for Orofacial Clefts","volume":"60","author":"Agopian","year":"2017","journal-title":"Am. J. Ind. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global Estimates of Diabetes Prevalence for 2013 and Projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00019605-199510000-00013","article-title":"Transverse Limb Deficiency, Facial Clefting and Hypoxic Renal Damage: An Association with Treatment of Maternal Hypertension?","volume":"4","author":"Hurst","year":"1995","journal-title":"Clin. Dysmorphol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1001\/jama.295.12.1404","article-title":"Incidence and Prognostic Implications of Stable Angina Pectoris among Women and Men","volume":"295","author":"Hemingway","year":"2006","journal-title":"JAMA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/CIRCULATIONAHA.105.576751","article-title":"Acute Myocardial Infarction in Pregnancy: A United States Population-Based Study","volume":"113","author":"James","year":"2006","journal-title":"Circulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/bdra.20177","article-title":"Maternal Diseases and Isolated Orofacial Clefts in Hungary","volume":"73","author":"Czeizel","year":"2005","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00439-008-0569-6","article-title":"The MSX1 Allele 4 Homozygous Child Exposed to Smoking at Periconception Is Most Sensitive in Developing Nonsyndromic Orofacial Clefts","volume":"124","author":"Krapels","year":"2008","journal-title":"Hum. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease","volume":"337","author":"Nordrehaug","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0002-9149(00)01137-1","article-title":"Homocysteine, a Risk Factor for Coronary Artery Disease or Not? A Meta-Analysis","volume":"86","author":"Cleophas","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1096-8628(19990903)86:1<71::AID-AJMG14>3.0.CO;2-Y","article-title":"Methylenetetrahydrofolate Reductase Thermolabile Variant and Oral Clefts","volume":"86","author":"Mills","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/bdra.20843","article-title":"Polymorphisms of Stress-Related Genes and the Risk of Nonsyndromic Cleft Lip with or without Cleft Palate","volume":"91","author":"Mostowska","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bdra.20369","article-title":"High Fever-Related Maternal Diseases as Possible Causes of Multiple Congenital Abnormalities: A Population-Based Case-Control Study","volume":"79","author":"Czeizel","year":"2007","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"205873841985557","DOI":"10.1177\/2058738419855571","article-title":"Association between Oral Cleft and Transcobalamin 2 Polymorphism in a Sample Study from Nassiriya, Iraq","volume":"33","author":"Carinci","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_107","first-page":"7","article-title":"Hyperhomocysteinemia and Cardiovascular Diseases","volume":"80","author":"Guieu","year":"2022","journal-title":"Ann. Biol. Clin."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/br.2020.1364","article-title":"5,10-Methylenetetrahydrofolate Reductase (MTHFR) C677T\/A1298C Polymorphisms in Patients with Nonsyndromic Cleft Lip Palate","volume":"13","author":"Komiyama","year":"2020","journal-title":"Biomed. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12291-017-0673-2","article-title":"Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene with Nosyndromic Cleft Lip\/Palate (NsCL\/P)","volume":"33","author":"Rai","year":"2018","journal-title":"Ind. J. Clin. Biochem."},{"key":"ref_110","first-page":"821","article-title":"Analysis of MTHFR Gene C.677C>T and C.1298A>C Polymorphisms in Iranian Patients with Non-Syndromic Cleft Lip and Palate","volume":"43","author":"Jahanbin","year":"2014","journal-title":"Iran. J. Public Health"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"638522","DOI":"10.3389\/fcell.2021.638522","article-title":"Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients with Non-Syndromic Cleft Palate Only","volume":"9","author":"Machado","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.archoralbio.2015.10.019","article-title":"Non-Syndromic Cleft Lip with or without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway","volume":"61","author":"Martinelli","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/humu.9411","article-title":"Study of Four Genes Belonging to the Folate Pathway: Transcobalamin 2 Is Involved in the Onset of Non-Syndromic Cleft Lip with or without Cleft Palate","volume":"27","author":"Martinelli","year":"2006","journal-title":"Hum. Mutat."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0722.2011.00824.x","article-title":"New Evidence for the Role of Cystathionine Beta-Synthase in Non-Syndromic Cleft Lip with or without Cleft Palate: CBS Role in CL\/P Onset","volume":"119","author":"Martinelli","year":"2011","journal-title":"Eur. J. Oral Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/bdra.23000","article-title":"Effects of Embryonic Hypoxia on Lip Formation","volume":"94","author":"Nagaoka","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ando.2010.07.001","article-title":"Birth Defects Observed with Maternal Carbimazole Treatment: Six Cases Reported to Nice\u2019s Pharmacovigilance Center","volume":"71","author":"Koenig","year":"2010","journal-title":"Ann. Endocrinol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/epi.13632","article-title":"Malformation Risk of Antiepileptic Drug Exposure during Pregnancy in Women with Epilepsy: Results from a Pregnancy Registry in South India","volume":"58","author":"Thomas","year":"2017","journal-title":"Epilepsia"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1741-4520.2010.00300.x","article-title":"Efficacy of Medical Care of Epileptic Pregnant Women Based on the Rate of Congenital Abnormalities in Their Offspring","volume":"51","author":"Czeizel","year":"2011","journal-title":"Congenit. Anom."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.eplepsyres.2014.01.021","article-title":"Topiramate Monotherapy Use in Women with and without Epilepsy: Pregnancy and Neonatal Outcomes","volume":"108","author":"Ford","year":"2014","journal-title":"Epilepsy Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/pgmj.54.628.98","article-title":"The Outcome of Pregnancy in Women Suffering from Migraine","volume":"54","author":"Wainscott","year":"1978","journal-title":"Postgrad. Med. J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/bdra.20288","article-title":"Maternal Severe Migraine and Risk of Congenital Limb Deficiencies","volume":"76","author":"Acs","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/pds.3612","article-title":"Topiramate Use in Pregnancy and the Birth Prevalence of Oral Clefts","volume":"23","author":"Mines","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00001648-200107000-00017","article-title":"Recall Bias in a Case-Control Surveillance System on the Use of Medicine during Pregnancy","volume":"12","author":"Rockenbauer","year":"2001","journal-title":"Epidemiology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/10556656211013687","article-title":"Cleft Lip and\/or Palate in Infants Prenatally Exposed to Opioids","volume":"59","author":"Louw","year":"2022","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/pds.2179","article-title":"Maternal Use of Antibiotics and the Risk of Orofacial Clefts: A Nationwide Cohort Study","volume":"21","author":"Hviid","year":"2012","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/humupd\/dmp052","article-title":"Teratogenic Mechanisms of Medical Drugs","volume":"16","author":"Miller","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/EDE.0b013e318258cb05","article-title":"Maternal Exposure to Amoxicillin and the Risk of Oral Clefts","volume":"23","author":"Lin","year":"2012","journal-title":"Epidemiology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.annepidem.2014.06.005","article-title":"First-Trimester Nonsystemic Corticosteroid Use and the Risk of Oral Clefts in Norway","volume":"24","author":"Skuladottir","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/bdra.23248","article-title":"Corticosteroid Use and Risk of Orofacial Clefts","volume":"100","author":"Skuladottir","year":"2014","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1001\/jama.2018.18307","article-title":"Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring","volume":"320","author":"Huybrechts","year":"2018","journal-title":"JAMA"},{"key":"ref_131","first-page":"e342","article-title":"Topiramate Use Early in Pregnancy and the Risk of Oral Clefts: A Pregnancy Cohort Study","volume":"90","author":"Huybrechts","year":"2018","journal-title":"Neurology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e2095","DOI":"10.1097\/GOX.0000000000002095","article-title":"Associations between Orofacial Clefting and Neonatal Abstinence Syndrome","volume":"7","author":"Mullens","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"020410","DOI":"10.7189\/jogh.10.020410","article-title":"The Role of Smoke from Cooking Indoors over an Open Flame and Parental Smoking on the Risk of Cleft Lip and Palate: A Case- Control Study in 7 Low-Resource Countries","volume":"10","author":"Auslander","year":"2020","journal-title":"J. Glob. Health"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1096-9926(199901)59:1<39::AID-TERA9>3.0.CO;2-7","article-title":"Candidate Genes for Nonsyndromic Cleft Lip and Palate and Maternal Cigarette Smoking and Alcohol Consumption: Evaluation of Genotype-Environment Interactions from a Population-Based Case-Control Study of Orofacial Clefts","volume":"59","author":"Romitti","year":"1999","journal-title":"Teratology"},{"key":"ref_135","first-page":"551","article-title":"Orofacial Clefts, Parental Cigarette Smoking, and Transforming Growth Factor-Alpha Gene Variants","volume":"58","author":"Shaw","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1093\/jn\/134.11.3106","article-title":"Maternal Nutritional Status and the Risk for Orofacial Cleft Offspring in Humans","volume":"134","author":"Krapels","year":"2004","journal-title":"J. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10654-016-0171-5","article-title":"Maternal Alcohol Binge-Drinking in the First Trimester and the Risk of Orofacial Clefts in Offspring: A Large Population-Based Pooling Study","volume":"31","author":"DeRoo","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/alcalc\/35.3.276","article-title":"Fetal alcohol syndrome: The origins of a moral panic","volume":"35","author":"Armstrong","year":"2000","journal-title":"Alcohol Alcohol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/aje\/kwq226","article-title":"Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-Based Case-Control Study in Norway, 1996\u20132001","volume":"172","author":"Boyles","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jamapediatrics.2013.4858","article-title":"Genetic Epidemiology and Nonsyndromic Structural Birth Defects: From Candidate Genes to Epigenetics","volume":"168","author":"Hobbs","year":"2014","journal-title":"JAMA Pediatr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/JOM.0000000000001191","article-title":"Associations Between Disinfection By-Product Exposures and Craniofacial Birth Defects","volume":"60","author":"Kaufman","year":"2018","journal-title":"J. Occup. Environ. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/bdr2.1386","article-title":"Maternal Arsenic Exposure and Nonsyndromic Orofacial Clefts","volume":"110","author":"Suhl","year":"2018","journal-title":"Birth Defects Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/15459624.2018.1484127","article-title":"Parental Occupational Pesticide Exposure and Nonsyndromic Orofacial Clefts","volume":"15","author":"Suhl","year":"2018","journal-title":"J. Occup. Environ. Hyg."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Takeuchi, M., Yoshida, S., Kawakami, C., Kawakami, K., and Ito, S. (2022). Association of Maternal Heavy Metal Exposure during Pregnancy with Isolated Cleft Lip and Palate in Offspring: Japan Environment and Children\u2019s Study (JECS) Cohort Study. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0265648"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12940-017-0294-5","article-title":"Maternal Occupational Exposure and Oral Clefts in Offspring","volume":"16","author":"Spinder","year":"2017","journal-title":"Environ. Health"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/oemed-2011-100245","article-title":"Maternal Occupational Exposure to Organic Solvents during Early Pregnancy and Risks of Neural Tube Defects and Orofacial Clefts","volume":"69","author":"Desrosiers","year":"2012","journal-title":"Occup. Environ. Med."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/12\/1846\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:29Z","timestamp":1760146109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/9\/12\/1846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":146,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["children9121846"],"URL":"https:\/\/doi.org\/10.3390\/children9121846","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]}}}