{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:47:54Z","timestamp":1760244474830,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of La Laguna and the Canary Council of Economy, Knowledge, and Employment (CEI program)","award":["2022\/20159"],"award-info":[{"award-number":["2022\/20159"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Hydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is unclear whether these changes occur before or as a result of the hydrocephalic illness. This report presents three cases of human fetuses with hydrocephalus: one non-communicating case, two communicating cases, and two controls. Hematoxylin\u2013Eosin (H&amp;E) or cresyl violet and immunohistochemistry with anti-transthyretin were used to analyze SCO morphological and secretory changes. We conclude that in the cases presented here, there could be an early regression in the SCO of the communicating cases that is not present in the non-communicating case.<\/jats:p>","DOI":"10.3390\/children9121966","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:20:57Z","timestamp":1671070857000},"page":"1966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus"],"prefix":"10.3390","volume":"9","author":[{"given":"Emilia","family":"Carmona-Calero","sequence":"first","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"},{"name":"Instituto de Investigaci\u00f3n y Ciencias Puerto del Rosario, 35600 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Gonz\u00e1lez-Toledo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-3553","authenticated-orcid":false,"given":"Luis","family":"Hern\u00e1ndez-Abad","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Casta\u00f1eyra-Perdomo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"},{"name":"Instituto de Investigaci\u00f3n y Ciencias Puerto del Rosario, 35600 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-2414","authenticated-orcid":false,"given":"Ibrahim","family":"Gonz\u00e1lez-Marrero","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","first-page":"202","article-title":"Zur Morphologie der circumventricul\u00e4ren Organe des Zwischenhirnes der S\u00e4ugetiere","volume":"22","year":"1959","journal-title":"Zool Anz Suppl."},{"key":"ref_2","first-page":"404","article-title":"Funktionelle histologische Untersuchungen \u00fcber die Organe des Zwischenhirndaches der Chordaten","volume":"102","author":"Oksche","year":"1956","journal-title":"Anat. 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