{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:46:58Z","timestamp":1789055218731,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2320-B-039-049-MY3"],"award-info":[{"award-number":["MOST107-2320-B-039-049-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2628-B-039-0008-MY3"],"award-info":[{"award-number":["MOST105-2628-B-039-0008-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST108-2314-B-039-048-MY3"],"award-info":[{"award-number":["MOST108-2314-B-039-048-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU109-ASIA-06"],"award-info":[{"award-number":["CMU109-ASIA-06"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-106-178"],"award-info":[{"award-number":["DMR-106-178"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Asia University Hospital","award":["10651004"],"award-info":[{"award-number":["10651004"]}]},{"name":"Asia University Hospital","award":["10751010"],"award-info":[{"award-number":["10751010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Resveratrol is a key component of red wine and other grape products. Recent studies have characterized resveratrol as a polyphenol, and shown its beneficial effects on cancer, metabolism, and infection. This study aimed to obtain insights into the biological effects of resveratrol on myopia. To this end, we examined its anti-inflammatory influence on human retinal pigment epithelium cells and in a monocular form deprivation (MFD)-induced animal model of myopia. In MFD-induced myopia, resveratrol increased collagen I level and reduced the expression levels of matrix metalloproteinase (MMP)2, transforming growth factor (TGF)-\u03b2, and nuclear factor (NF)-\u03baB expression levels. It also suppressed the levels of tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-6, and IL-1\u03b2. Resveratrol exhibited no significant cytotoxicity in ARPE-19 cells. Downregulation of inflammatory cytokine production, and inhibition of AKT, c-Raf, Stat3, and NF\u03baB phosphorylation were observed in ARPE-19 cells that were treated with resveratrol. In conclusion, the findings suggest that resveratrol inhibits inflammatory effects by blocking the relevant signaling pathways, to ameliorate myopia development. This may make it a natural candidate for drug development for myopia.<\/jats:p>","DOI":"10.3390\/cimb43020052","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:18:52Z","timestamp":1626643132000},"page":"716-727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model"],"prefix":"10.3390","volume":"43","author":[{"given":"Yu-An","family":"Hsu","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 413, Taiwan"},{"name":"Division of Chinese Medicine, Asia University Hospital, Taichung 413, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Chien","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Tzu Chi Hospital, Taichung 427, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Shyh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Beauty Science, National Taichung University of Science and Technology, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie Jiin-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yen","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Center, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ju","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung 404, Taiwan"},{"name":"Eye Center, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-3232","authenticated-orcid":false,"given":"Lei","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung 404, Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan"},{"name":"Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2471\/BLT.07.041210","article-title":"Global magnitude of visual impairment caused by uncorrected refractive errors in 2004","volume":"86","author":"Resnikoff","year":"2008","journal-title":"Bull. 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