{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:53:23Z","timestamp":1791608003995,"version":"4.3.4"},"reference-count":139,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Endometriosis is a chronic gynecological disease defined by the presence of endometrial-like tissue found outside the uterus, most commonly in the peritoneal cavity. Endometriosis lesions are heterogenous but usually contain endometrial stromal cells and epithelial glands, immune cell infiltrates and are vascularized and innervated by nerves. The complex etiopathogenesis and heterogenity of the clinical symptoms, as well as the lack of a specific non-invasive diagnostic biomarkers, underline the need for more advanced diagnostic tools. Unfortunately, the contribution of environmental, hormonal and immunological factors in the disease etiology is insufficient, and the contribution of genetic\/epigenetic factors is still fragmentary. Therefore, there is a need for more focused study on the molecular mechanisms of endometriosis and non-invasive diagnostic monitoring systems. MicroRNAs (miRNAs) demonstrate high stability and tissue specificity and play a significant role in modulating a range of molecular pathways, and hence may be suitable diagnostic biomarkers for the origin and development of endometriosis. Of these, the most frequently studied are those related to endometriosis, including those involved in epithelial\u2013mesenchymal transition (EMT), whose expression is altered in plasma or endometriotic lesion biopsies; however, the results are ambiguous. Specific miRNAs expressed in endometriosis may serve as diagnostics markers with prognostic value, and they have been proposed as molecular targets for treatment. The aim of this review is to present selected miRNAs associated with EMT known to have experimentally confirmed significance, and discuss their utility as biomarkers in endometriosis.<\/jats:p>","DOI":"10.3390\/cimb43020064","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T04:33:29Z","timestamp":1628138009000},"page":"900-916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Circulating miRNAs Related to Epithelial\u2013Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis"],"prefix":"10.3390","volume":"43","author":[{"given":"Anna","family":"Zubrzycka","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251, C-5, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9856-0764","authenticated-orcid":false,"given":"Monika","family":"Migdalska-S\u0119k","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251, C-5, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"J\u0119drzejczyk","sequence":"additional","affiliation":[{"name":"Operative and Conservative Gynecology Ward, Dr. K. Jonscher Municipal Medical Centre, Milionowa 14, 93-113 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-1458","authenticated-orcid":false,"given":"Ewa","family":"Brzezia\u0144ska-Lasota","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251, C-5, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moga, M.A., B\u0103lan, A., Dimienescu, O.G., Burtea, V., Dragomir, R.M., and Anastasiu, C.V. (2019). Circulating miRNAs as Biomarkers for Endometriosis and Endometriosis-Related Ovarian Cancer-An Overview. J. Clin. 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