{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:54:26Z","timestamp":1790949266354,"version":"4.1.0"},"reference-count":185,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>An association between obesity and carpal tunnel syndrome is found in many epidemiological studies. Therefore, there is a need to evaluate the physiopathological links that could explain the association between these two entities. Ectopic adipose tissue is responsible for metabolic syndrome and inflammation, and is a major risk factor for diabetes and cardiovascular diseases. Taking these elements into consideration, we conducted an extensive literature revision of the subject, considering as ectopic fat-related mechanisms the following: (a) the direct compression and the association with the metabolic syndrome of the fat deposition around the wrist, (b) the insulin resistance, dyslipidemia, inflammatory, and oxidative mechanisms related to the central deposition of the fat, (c) the impaired muscle contraction and metabolism related to myosteatosis. Each section presents the cellular pathways which are modified by the ectopic deposition of the adipose tissue and the impact in the pathogeny of the carpal tunnel syndrome. In conclusion, the experimental and clinical data support the epidemiological findings. Efforts to reduce the obesity epidemics will improve not only cardio-metabolic health but will reduce the burden of the disability-free life expectancy due to the carpal tunnel syndrome.<\/jats:p>","DOI":"10.3390\/cimb44060181","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:49:14Z","timestamp":1654771754000},"page":"2646-2663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Pathological Links between Adiposity and the Carpal Tunnel Syndrome"],"prefix":"10.3390","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-0562","authenticated-orcid":false,"given":"Marina Ruxandra","family":"Otelea","sequence":"first","affiliation":[{"name":"Clinical Department 5, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Nartea","sequence":"additional","affiliation":[{"name":"Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Rehabilitation, Physical Medicine and Balneoclimatology, 030079 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-2653","authenticated-orcid":false,"given":"Florina Georgeta","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department V, Internal Medicine, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Emergency Municipal Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoli","family":"Covaleov","sequence":"additional","affiliation":[{"name":"Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brindusa Ilinca","family":"Mitoiu","sequence":"additional","affiliation":[{"name":"Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Sarah","family":"Nica","sequence":"additional","affiliation":[{"name":"Clinical Department 9, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Rehabilitation, Physical Medicine and Balneoclimatology, 030079 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neurol.2011.05.010","article-title":"Carpal tunnel syndrome surgery in France in 2008: Patients\u2019 characteristics and management","volume":"167","author":"Tuppin","year":"2011","journal-title":"Rev. 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