{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:23:02Z","timestamp":1790630582622,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000125"],"award-info":[{"award-number":["32000125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20A180014"],"award-info":[{"award-number":["20A180014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["5101049170192"],"award-info":[{"award-number":["5101049170192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["222102310291"],"award-info":[{"award-number":["222102310291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["222102310589"],"award-info":[{"award-number":["222102310589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22A180018"],"award-info":[{"award-number":["22A180018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21A180009"],"award-info":[{"award-number":["21A180009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["32000125"],"award-info":[{"award-number":["32000125"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["20A180014"],"award-info":[{"award-number":["20A180014"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["5101049170192"],"award-info":[{"award-number":["5101049170192"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["222102310291"],"award-info":[{"award-number":["222102310291"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["222102310589"],"award-info":[{"award-number":["222102310589"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["22A180018"],"award-info":[{"award-number":["22A180018"]}]},{"name":"National Fostering Science Fund Project of Henan Normal University","award":["21A180009"],"award-info":[{"award-number":["21A180009"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["32000125"],"award-info":[{"award-number":["32000125"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["20A180014"],"award-info":[{"award-number":["20A180014"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["5101049170192"],"award-info":[{"award-number":["5101049170192"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["222102310291"],"award-info":[{"award-number":["222102310291"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["222102310589"],"award-info":[{"award-number":["222102310589"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["22A180018"],"award-info":[{"award-number":["22A180018"]}]},{"name":"Doctoral Research Foundation of Henan Normal University","award":["21A180009"],"award-info":[{"award-number":["21A180009"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["32000125"],"award-info":[{"award-number":["32000125"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["20A180014"],"award-info":[{"award-number":["20A180014"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["5101049170192"],"award-info":[{"award-number":["5101049170192"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["222102310291"],"award-info":[{"award-number":["222102310291"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["222102310589"],"award-info":[{"award-number":["222102310589"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["22A180018"],"award-info":[{"award-number":["22A180018"]}]},{"name":"Scientific and Technological Breakthroughs Project of Henan","award":["21A180009"],"award-info":[{"award-number":["21A180009"]}]},{"name":"Higher Education Research Key Project of Henan","award":["32000125"],"award-info":[{"award-number":["32000125"]}]},{"name":"Higher Education Research Key Project of Henan","award":["20A180014"],"award-info":[{"award-number":["20A180014"]}]},{"name":"Higher Education Research Key Project of Henan","award":["5101049170192"],"award-info":[{"award-number":["5101049170192"]}]},{"name":"Higher Education Research Key Project of Henan","award":["222102310291"],"award-info":[{"award-number":["222102310291"]}]},{"name":"Higher Education Research Key Project of Henan","award":["222102310589"],"award-info":[{"award-number":["222102310589"]}]},{"name":"Higher Education Research Key Project of Henan","award":["22A180018"],"award-info":[{"award-number":["22A180018"]}]},{"name":"Higher Education Research Key Project of Henan","award":["21A180009"],"award-info":[{"award-number":["21A180009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions, such as biosynthesis, lipid metabolism, oxidative phosphorylation, cell signal transduction, and apoptosis. Mitochondrial dysfunction is manifested in different aspects, like increased mitochondrial reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, adenosine triphosphate (ATP) synthesis disorder, abnormal mitophagy, as well as changes in mitochondrial morphology and structure. Mitochondrial dysfunction is related to the occurrence and development of various chronic liver diseases, including hepatocellular carcinoma (HCC), viral hepatitis, drug-induced liver injury (DILI), alcoholic fatty liver (AFL), and non-alcoholic fatty liver (NAFL). In this review, we summarize and discuss the role and mechanisms of mitochondrial dysfunction in chronic liver disease, focusing on and discussing some of the latest studies on mitochondria and chronic liver disease.<\/jats:p>","DOI":"10.3390\/cimb44070218","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T21:19:28Z","timestamp":1657487968000},"page":"3156-3165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Mitochondrial Dysfunction and Chronic Liver Disease"],"prefix":"10.3390","volume":"44","author":[{"given":"Chunyan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Institute of Biomedical Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6772-5063","authenticated-orcid":false,"given":"Bingyu","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Institute of Biomedical Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan International Joint Laboratory of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"College of Life Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Institute of Biomedical Science, Henan Normal University, Xinxiang 453007, China"},{"name":"Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8900122","DOI":"10.1155\/2021\/8900122","article-title":"Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases","volume":"2021","author":"Chu","year":"2021","journal-title":"Anal. Cell Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17562848211031394","DOI":"10.1177\/17562848211031394","article-title":"Mitochondrial dysfunction and liver disease: Role, relevance, and potential for therapeutic modulation","volume":"14","author":"Middleton","year":"2021","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Xue, C., Gu, X., Li, G., Bao, Z., and Li, L. (2020). Mitochondrial Mechanisms of Necroptosis in Liver Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010066"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.3892\/mmr.2015.4029","article-title":"Promotion of mitochondrial energy metabolism during hepatocyte apoptosis in a rat model of acute liver failure","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"114282","DOI":"10.1016\/j.bcp.2020.114282","article-title":"Therapeutic potential of targeting mitochondrial dynamics in cancer","volume":"182","author":"Rodrigues","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcdb.2019.05.022","article-title":"Mitochondria as playmakers of apoptosis, autophagy and senescence","volume":"98","author":"Abate","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: An update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yamada, Y., Takano, Y., Abe, J., Hibino, M., and Harashima, H. (2020). Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress. Biomolecules, 10.","DOI":"10.3390\/biom10010083"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2174\/138945011795528877","article-title":"Mitochondria in chronic liver disease","volume":"12","author":"Grattagliano","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-pharmtox-010716-104908","article-title":"Repairing Mitochondrial Dysfunction in Disease","volume":"58","author":"Sorrentino","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.redox.2017.02.012","article-title":"Mitochondrial composition and function under the control of hypoxia","volume":"12","author":"Fuhrmann","year":"2017","journal-title":"Redox Biol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Doblado, L., Lueck, C., Rey, C., and Samhan-Arias, A.K. (2021). Mitophagy in Human Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083903"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ke, P.Y. (2020). Mitophagy in the Pathogenesis of Liver Diseases. Cells, 9.","DOI":"10.3390\/cells9040831"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"s104","DOI":"10.7861\/clinmedicine.16-6-s104","article-title":"Drug-induced liver injury","volume":"16","author":"Katarey","year":"2016","journal-title":"Clin. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cld.2019.09.008","article-title":"Drug-Induced Liver Injury in the Setting of Analgesic Use","volume":"24","author":"Darr","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"ref_17","first-page":"75","article-title":"Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: Current understanding and future perspectives","volume":"4","author":"Ramachandran","year":"2018","journal-title":"J. Clin. Transl. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/17474124.2021.1857238","article-title":"Biomarkers of drug-induced liver injury: A mechanistic perspective through acetaminophen hepatotoxicity","volume":"15","author":"Umbaugh","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","article-title":"Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls","volume":"11","author":"Jaeschke","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0039-1679919","article-title":"Acetaminophen Hepatotoxicity","volume":"39","author":"Ramachandran","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"(2019). EASL Clinical Practice Guidelines: Drug-induced liver injury. J. Hepatol., 70, 1222\u20131261.","DOI":"10.1016\/j.jhep.2019.02.014"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00204-021-02985-6","article-title":"Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice","volume":"95","author":"Nguyen","year":"2021","journal-title":"Arch. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"114930","DOI":"10.1016\/j.taap.2020.114930","article-title":"Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline","volume":"392","author":"Hu","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00204-021-03211-z","article-title":"Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose","volume":"96","author":"Akakpo","year":"2022","journal-title":"Arch. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/15563650.2021.1996591","article-title":"Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: A case series","volume":"60","author":"Link","year":"2022","journal-title":"Clin. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1007\/s00204-021-03142-9","article-title":"Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole","volume":"95","author":"Akakpo","year":"2021","journal-title":"Arch. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119669","DOI":"10.1016\/j.lfs.2021.119669","article-title":"The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats","volume":"279","author":"Ulger","year":"2021","journal-title":"Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/tgh-20-125","article-title":"Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease","volume":"6","author":"Prasun","year":"2021","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9986299","DOI":"10.1155\/2021\/9986299","article-title":"Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD","volume":"2021","author":"Durand","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/ars.2021.0157","article-title":"Inhibition of fatty acid translocase (FAT\/CD36) palmitoylation enhances hepatic fatty acid \u03b2-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1","volume":"36","author":"Zeng","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/s41467-020-16991-2","article-title":"Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation","volume":"11","author":"Fortner","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117633","DOI":"10.1016\/j.lfs.2020.117633","article-title":"High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling","volume":"252","author":"Song","year":"2020","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115758","DOI":"10.1016\/j.taap.2021.115758","article-title":"Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3","volume":"432","author":"Geng","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gao, W., Xu, B., Zhang, Y., Liu, S., Duan, Z., Chen, Y., and Zhang, X. (2022). Baicalin Attenuates Oxidative Stress in a Tissue-Engineered Liver Model of NAFLD by Scavenging Reactive Oxygen Species. Nutrients, 14.","DOI":"10.3390\/nu14030541"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21037\/tgh.2019.10.02","article-title":"Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: Spectrum and diagnosis","volume":"5","author":"Sharma","year":"2020","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3748\/wjg.v27.i1.1","article-title":"Experimental models of metabolic and alcoholic fatty liver disease","volume":"27","author":"Buyco","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41467-022-28201-2","article-title":"Depletion of mitochondrial methionine adenosyltransferase \u03b11 triggers mitochondrial dysfunction in alcohol-associated liver disease","volume":"13","author":"Murray","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1039\/D0FO03220D","article-title":"Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondrial function and mitophagy balance in rats","volume":"12","author":"Zhao","year":"2021","journal-title":"Food Funct."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ma, Z., Zhang, Y., Li, Q., Xu, M., Bai, J., and Wu, S. (2017). Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1\u03b1 expression and mitochondrial ROS production. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183426"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174324","DOI":"10.1016\/j.ejphar.2021.174324","article-title":"Caveolin-1 attenuates acetaminophen aggravated lipid accumulation in alcoholic fatty liver by activating mitophagy via the Pink-1\/Parkin pathway","volume":"908","author":"Jiang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e1801339","DOI":"10.1002\/mnfr.201801339","article-title":"Wolfberry-Derived Zeaxanthin Dipalmitate Attenuates Ethanol-Induced Hepatic Damage","volume":"63","author":"Gao","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1874467208666150817111114","article-title":"Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances","volume":"10","author":"Abdelmegeed","year":"2017","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yang, Y.M., Cho, Y.E., and Hwang, S. (2022). Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020774"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1002\/fsn3.2526","article-title":"Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage","volume":"9","author":"Li","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"713721","DOI":"10.3389\/fonc.2021.713721","article-title":"Mitochondrial Quality Control in Hepatocellular Carcinoma","volume":"11","author":"Bian","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lee, H.Y., Nga, H.T., Tian, J., and Yi, H.S. (2021). Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma. Cells, 10.","DOI":"10.3390\/cells10081901"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2019.03.037","article-title":"Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice","volume":"136","author":"Shetty","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mito.2021.03.001","article-title":"Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis","volume":"58","author":"Shetty","year":"2021","journal-title":"Mitochondrion"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Han, Y.S., Yi, E.Y., Jegal, M.E., and Kim, Y.J. (2021). Cancer Stem-Like Phenotype of Mitochondria Dysfunctional Hep3B Hepatocellular Carcinoma Cell Line. Cells, 10.","DOI":"10.3390\/cells10071608"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/1873-3468.13546","article-title":"UCP2 gene polymorphisms in obesity and diabetes, and the role of UCP2 in cancer","volume":"593","author":"Li","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1158\/1078-0432.CCR-18-0177","article-title":"Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR","volume":"24","author":"Veiga","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3727\/096504001108747495","article-title":"Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells","volume":"12","author":"Ying","year":"2001","journal-title":"Oncol. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40170-021-00276-3","article-title":"MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation","volume":"10","author":"Zhang","year":"2022","journal-title":"Cancer Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41419-021-03827-0","article-title":"Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity","volume":"12","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/ptr.7398","article-title":"The nature compound dehydrocrenatidine exerts potent antihepatocellular carcinoma by destroying mitochondrial complexes in vitro and in vivo","volume":"36","author":"Hou","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"114073","DOI":"10.1016\/j.jep.2021.114073","article-title":"Aidi injection induces apoptosis of hepatocellular carcinoma cells through the mitochondrial pathway","volume":"274","author":"Lan","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","first-page":"1","article-title":"CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma","volume":"17","author":"Yao","year":"2021","journal-title":"Autophagy"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.3748\/wjg.v27.i26.4018","article-title":"Viral hepatitis update: Progress and perspectives","volume":"27","author":"Pisano","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/jvh.13371","article-title":"Disease burden of viral hepatitis A, B, C and E: A systematic analysis","volume":"27","author":"Liu","year":"2020","journal-title":"J. Viral Hepat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhep.2020.09.013","article-title":"A global investment framework for the elimination of hepatitis B","volume":"74","author":"Howell","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e0132821","DOI":"10.1128\/spectrum.01328-21","article-title":"Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy","volume":"10","author":"Zai","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"116464","DOI":"10.1016\/j.lfs.2019.05.020","article-title":"Mitochondrial DNA in liver inflammation and oxidative stress","volume":"236","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbadis.2017.09.023","article-title":"The interaction between mitochondria and oncoviruses","volume":"1864","author":"Song","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_67","first-page":"2861","article-title":"Effect of HBx on inflammation and mitochondrial oxidative stress in mouse hepatocytes","volume":"19","author":"Ling","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00011-020-01351-z","article-title":"Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation","volume":"69","author":"Xie","year":"2020","journal-title":"Inflamm. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3892\/or.2016.5225","article-title":"Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore","volume":"37","author":"Gao","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12964-021-00762-7","article-title":"Calcium signaling in hepatitis B virus infection and its potential as a therapeutic target","volume":"19","author":"Kong","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Casciano, J.C., Duchemin, N.J., Lamontagne, R.J., Steel, L.F., and Bouchard, M.J. (2017). Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0168328"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jabeen, K., Malik, U., Mansoor, S., Shahzad, S., Zahid, S., and Javed, A. (2021). Effect of oxidative stress and calcium deregulation on FAM26F (CALHM6) expression during hepatitis B virus infection. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-05888-0"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wernberg, C.W., Ravnskjaer, K., Lauridsen, M.M., and Thiele, M. (2021). The Role of Diagnostic Biomarkers, Omics Strategies, and Single-Cell Sequencing for Nonalcoholic Fatty Liver Disease in Severely Obese Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10050930"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/44\/7\/218\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:47:18Z","timestamp":1760140038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/44\/7\/218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,9]]},"references-count":74,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cimb44070218"],"URL":"https:\/\/doi.org\/10.3390\/cimb44070218","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,9]]}}}