{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:25:00Z","timestamp":1787714700074,"version":"build-2784847793"},"reference-count":194,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiological mechanisms, disease progression being secondary to inflammation, demyelination, or axonal degeneration. Early identification of changes associated with axonal degeneration or further investigation of the molecular processes underlying remyelination are current concerns of researchers in the field in view of the associated therapeutic potential. This article aims to review and summarize the scientific literature related to the main molecular mechanisms involved in defining ON as well as to analyze existing data in the literature on remyelination strategies in ON and their impact on long-term prognosis.<\/jats:p>","DOI":"10.3390\/cimb44090272","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T23:35:57Z","timestamp":1662420957000},"page":"3959-3979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Optic Neuritis in Multiple Sclerosis\u2014A Review of Molecular Mechanisms Involved in the Degenerative Process"],"prefix":"10.3390","volume":"44","author":[{"given":"Manuela Andreea","family":"Ciap\u0103","sequence":"first","affiliation":[{"name":"Emergency Hospital Dimitrie Castroian, 735100 Hu\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia Lidia","family":"\u0218alaru","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Ia\u0219i, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-4561","authenticated-orcid":false,"given":"Cristian","family":"St\u0103tescu","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Ia\u0219i, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Andy","family":"Sasc\u0103u","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Institute of Cardiovascular Diseases, 700503 Ia\u0219i, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-7714","authenticated-orcid":false,"given":"Camelia Margareta","family":"Bogd\u0103nici","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties (II), University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, 700115 Ia\u0219i, Romania"},{"name":"Ophthalmology Clinic, Saint Spiridon Hospital, Ia\u0219i 700111, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrneurol.2010.1","article-title":"Environmental Factors and Their Timing in Adult-Onset Multiple Sclerosis","volume":"6","author":"Handel","year":"2010","journal-title":"Nat. Rev. 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