{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:25:27Z","timestamp":1774992327408,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Postdoctoral Science Foundation","award":["2021M703747"],"award-info":[{"award-number":["2021M703747"]}]},{"name":"China Postdoctoral Science Foundation","award":["2021A1515111109"],"award-info":[{"award-number":["2021A1515111109"]}]},{"name":"China Postdoctoral Science Foundation","award":["82201756"],"award-info":[{"award-number":["82201756"]}]},{"name":"China Postdoctoral Science Foundation","award":["82071636"],"award-info":[{"award-number":["82071636"]}]},{"name":"China Postdoctoral Science Foundation","award":["GPKLBI202104"],"award-info":[{"award-number":["GPKLBI202104"]}]},{"name":"GuangDong Basic and Applied Basic Research Foundation","award":["2021M703747"],"award-info":[{"award-number":["2021M703747"]}]},{"name":"GuangDong Basic and Applied Basic Research Foundation","award":["2021A1515111109"],"award-info":[{"award-number":["2021A1515111109"]}]},{"name":"GuangDong Basic and Applied Basic Research Foundation","award":["82201756"],"award-info":[{"award-number":["82201756"]}]},{"name":"GuangDong Basic and Applied Basic Research Foundation","award":["82071636"],"award-info":[{"award-number":["82071636"]}]},{"name":"GuangDong Basic and Applied Basic Research Foundation","award":["GPKLBI202104"],"award-info":[{"award-number":["GPKLBI202104"]}]},{"name":"National Natural Science Foundation of China","award":["2021M703747"],"award-info":[{"award-number":["2021M703747"]}]},{"name":"National Natural Science Foundation of China","award":["2021A1515111109"],"award-info":[{"award-number":["2021A1515111109"]}]},{"name":"National Natural Science Foundation of China","award":["82201756"],"award-info":[{"award-number":["82201756"]}]},{"name":"National Natural Science Foundation of China","award":["82071636"],"award-info":[{"award-number":["82071636"]}]},{"name":"National Natural Science Foundation of China","award":["GPKLBI202104"],"award-info":[{"award-number":["GPKLBI202104"]}]},{"name":"Guangdong Provincial Key Lab of Biomedical Imaging","award":["2021M703747"],"award-info":[{"award-number":["2021M703747"]}]},{"name":"Guangdong Provincial Key Lab of Biomedical Imaging","award":["2021A1515111109"],"award-info":[{"award-number":["2021A1515111109"]}]},{"name":"Guangdong Provincial Key Lab of Biomedical Imaging","award":["82201756"],"award-info":[{"award-number":["82201756"]}]},{"name":"Guangdong Provincial Key Lab of Biomedical Imaging","award":["82071636"],"award-info":[{"award-number":["82071636"]}]},{"name":"Guangdong Provincial Key Lab of Biomedical Imaging","award":["GPKLBI202104"],"award-info":[{"award-number":["GPKLBI202104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Background: Brain-derived neurotrophic factor (BDNF), as a member of the nerve growth factor family, has been mentioned more and more frequently in recent literature reports. Among them, content about the male genitourinary system is also increasing. Objective and Rationale: BDNF plays an important role in the male genitourinary system. At the same time, the literature in this field is constantly increasing. Therefore, we systematically summarized the literature in order to more intuitively show the function of BDNF and its receptor in the male genitourinary system and its potential clinical application. Search Methods: An electronic search of, e.g., PubMed, scholar.google and Scopus, for articles relating to BDNF and its receptor in the male genitourinary system. Outcomes: In the male genitourinary system, BDNF and its receptors TrkB and p75 participate in a series of normal physiological activities, such as the maturation and morphogenesis of testes and epididymis and maintenance of isolated sperm motility. Similarly, an imbalance of the circulating concentration of BDNF also mediates the pathophysiological process of many diseases, such as prostate cancer, benign prostatic hyperplasia, male infertility, diabetes erectile dysfunction, penile sclerosis, and bladder fibrosis. As a consequence, we conclude that BDNF and its receptor are key regulatory proteins in the male genitourinary system, which can be used as potential therapeutic targets and markers for disease diagnosis.<\/jats:p>","DOI":"10.3390\/cimb45010008","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:33:33Z","timestamp":1672126413000},"page":"110-121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Function of BDNF and Its Receptor in the Male Genitourinary System and Its Potential Clinical Application"],"prefix":"10.3390","volume":"45","author":[{"given":"Xiaoli","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Urology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-558X","authenticated-orcid":false,"given":"Yuxin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-12-420170-5.00006-4","article-title":"BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders","volume":"122","author":"Andero","year":"2014","journal-title":"Prog. 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