{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:23:07Z","timestamp":1773094987715,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy\/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients\u2019 HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (&gt;30 years old) (p = 0.007). No statistically significant association was found between HLA-C allele expression and response to MTX, despite a higher frequency of HLA-C*06 in responders compared to non-responders. Thus, HLA-C*07 could be a biomarker of late psoriasis onset in the Moroccan population.<\/jats:p>","DOI":"10.3390\/cimb45020066","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T02:29:31Z","timestamp":1674700171000},"page":"1012-1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["HLA-C Genotyping Reveals Haplotype C*07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients"],"prefix":"10.3390","volume":"45","author":[{"given":"Chaimaa","family":"Benlabsir","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Riyad","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-0307","authenticated-orcid":false,"given":"Imane El Idrissi","family":"Saik","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanaa","family":"Ettayebi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oussama","family":"Aazzane","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawtar","family":"Nassar","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soukaina","family":"Zaher","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siham","family":"Bennani","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory, Pasteur Institute of Morocco, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-8220","authenticated-orcid":false,"given":"Brahim","family":"Admou","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Center of Clinical Research, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh 40000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-9123","authenticated-orcid":false,"given":"Samy","family":"Housbane","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"},{"name":"Medical Informatics Department, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5050","authenticated-orcid":false,"given":"Khalid","family":"Sadki","sequence":"additional","affiliation":[{"name":"Oral Biotechnology Laboratory, Fundamental Sciences Department, Faculty of Dental Medicine, Mohammed V University, Rabat 10000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumiya","family":"Chiheb","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"},{"name":"Dermatology and Venerology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-0484","authenticated-orcid":false,"given":"Hassan","family":"Fellah","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaad.2013.11.013","article-title":"Psoriasis prevalence among adults in the United States","volume":"70","author":"Rachakonda","year":"2014","journal-title":"J. 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