{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:34:43Z","timestamp":1771619683190,"version":"3.50.1"},"reference-count":126,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Dementia represents a clinical syndrome characterised by progressive decline in memory, language, visuospatial and executive function, personality, and behaviour, causing loss of abilities to perform instrumental or essential activities of daily living. The most common cause of dementia is Alzheimer\u2019s disease (AD), which accounts for up to 80% of all dementia cases. Despite that extensive studies regarding the etiology and risk factors have been performed in recent decades, and how the current knowledge about AD pathophysiology significantly improved with the recent advances in science and technology, little is still known about its treatment options. In this controverted context, a nutritional approach could be a promising way to formulate improved AD management strategies and to further analyse possible treatment strategy options based on personalised diets, as Nutritional Psychiatry is currently gaining relevance in neuropsychiatric disease treatment. Based on the current knowledge of AD pathophysiology, as well as based on the repeatedly documented anti-inflammatory and antioxidant potential of different functional foods, we aimed to find, describe, and correlate several dietary compounds that could be useful in formulating a nutritional approach in AD management. We performed a screening for relevant studies on the main scientific databases using keywords such as \u201cAlzheimer\u2019s disease\u201d, \u201cdementia\u201d, \u201ctreatment\u201d, \u201cmedication\u201d, \u201ctreatment alternatives\u201d, \u201cvitamin E\u201d, \u201cnutrition\u201d, \u201cselenium\u201d, \u201cGinkgo biloba\u201d, \u201cantioxidants\u201d, \u201cmedicinal plants\u201d, and \u201ctraditional medicine\u201d in combinations. Results: nutrients could be a key component in the physiologic and anatomic development of the brain. Several nutrients have been studied in the pursuit of the mechanism triggered by the pathology of AD: vitamin D, fatty acids, selenium, as well as neuroprotective plant extracts (i.e., Ginkgo biloba, Panax ginseng, Curcuma longa), suggesting that the nutritional patterns could modulate the cognitive status and provide neuroprotection. The multifactorial origin of AD development and progression could suggest that nutrition could greatly contribute to the complex pathological picture. The identification of adequate nutritional interventions and the not yet fully understood nutrient activity in AD could be the next steps in finding several innovative treatment options for neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/cimb45020098","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:51:06Z","timestamp":1676008266000},"page":"1519-1535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Quest for Neurodegenerative Disease Treatment\u2014Focusing on Alzheimer\u2019s Disease Personalised Diets"],"prefix":"10.3390","volume":"45","author":[{"given":"Matei","family":"Palimariciuc","sequence":"first","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana-Miruna","family":"Balmus","sequence":"additional","affiliation":[{"name":"Department of Exact Sciences and Natural Sciences, Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of Iasi, Alexandru Lapusneanu Street, No. 26, 700057 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Giread\u0103","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, B dul Carol I, No. 11, 700506 Iasi, Romania"},{"name":"Academy of Romanian Scientists, Splaiul Independentei nr. 54, Sector 5, 050094 Bucuresti, Romania"},{"name":"Centre of Biomedical Research, Romanian Academy, B dul Carol I, No. 8, 700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Chiri\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin-Constantin","family":"Iordache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universitatii Strada, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Apostu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-0205","authenticated-orcid":false,"given":"Romeo Petru","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","first-page":"407","article-title":"Neurodegenerative diseases","volume":"163","author":"Checkoway","year":"2011","journal-title":"IARC Sci. Publ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jalz.2016.04.002","article-title":"Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011\u20132013","volume":"13","author":"Goodman","year":"2017","journal-title":"Alzheimer\u2019s Dement. J. Alzheimer\u2019s Assoc."},{"key":"ref_3","unstructured":"Alzheimer\u2019s Society, UK (2020, June 30). Alzheimer\u2019s Society\u2019s View on Demography. Available online: https:\/\/www.alzheimers.org.uk\/about-us\/policy-and-influencing\/what-we-think\/demography."},{"key":"ref_4","unstructured":"GBD 2019 Dementia Forecasting Collaborators (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lancet. Public Health, 7, e105\u2013e125."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-180766","article-title":"Treatment Combinations for Alzheimer\u2019s Disease: Current and Future Pharmacotherapy Options","volume":"67","author":"Cummings","year":"2019","journal-title":"J Alzheimers Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-030-32633-3_3","article-title":"Treatment Development for Alzheimer\u2019s Disease: How Are We Doing?","volume":"1195","author":"Lyketsos","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7861\/clinmedicine.16-3-247","article-title":"Drug treatments in Alzheimer\u2019s disease","volume":"16","author":"Briggs","year":"2016","journal-title":"Clin Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1111\/bph.14767","article-title":"Therapeutics for dementia and Alzheimer\u2019s disease: New directions for precision medicine","volume":"176","author":"Duce","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2040622312452387","article-title":"Management of patients with Alzheimer\u2019s disease: Pharmacological treatment and quality of life","volume":"3","author":"Mossello","year":"2012","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jagp.2015.07.007","article-title":"Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials","volume":"23","author":"Schmidt","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry Off. J. Am. Assoc. Geriatr. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e2220","DOI":"10.1212\/WNL.0000000000011832","article-title":"Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality","volume":"96","author":"Xu","year":"2021","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1038\/s41598-021-85625-4","article-title":"Effect of memantine, an anti-Alzheimer\u2019s drug, on rodent microglial cells in vitro","volume":"11","author":"Mizoguchi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_13","unstructured":"Padda, I.S., and Parmar, M. (2022, August 31). Aducanumab, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK573062\/."},{"key":"ref_14","first-page":"462","article-title":"Aducanumab Is Not Effective for Mild Cognitive Impairment or Mild Alzheimer Dementia and Has Major Safety Issues","volume":"106","author":"Ebell","year":"2022","journal-title":"Am. Fam. Physician"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Panza, F., Lozupone, M., Solfrizzi, V., Custodero, C., Valiani, V., D\u2019Introno, A., Stella, E., Stallone, R., Piccininni, M., and Bellomo, A. (2018). Chapter 9-Contribution of Mediterranean Diet in the Prevention of Alzheimer\u2019s Disease, Academic Press.","DOI":"10.1016\/B978-0-12-811959-4.00009-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3945\/ajcn.2010.29673","article-title":"Accruing evidence on benefits of adherence to the Mediterranean diet on health: An updated systematic review and meta-analysis","volume":"92","author":"Sofi","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Casares, N., Gallego Fuentes, P., Barbancho, M.\u00c1., L\u00f3pez-Gigosos, R., Garc\u00eda-Rodr\u00edguez, A., and Guti\u00e9rrez-Bedmar, M. (2021). Alzheimer\u2019s Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204642"},{"key":"ref_18","first-page":"CD011905","article-title":"Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment","volume":"11","author":"McCleery","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","first-page":"29","article-title":"The role of nutrition in Alzheimer\u2019s disease","volume":"72","author":"Jeziorek","year":"2021","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nishal, S., Phaugat, P., Bazaad, J., Dhaka, R., Khatkar, S., Khatkar, A., Khayatkashani, M., Alizadeh, P., Haghighi, S.M., and Mehri, M. (2023). A concise review of common plant-derived compounds as potential therapy for Alzheimer\u2019s disease and Parkinson\u2019s disease: Insight into Structure-Activity-Relationship. CNS Neurol. Disord. Drug Targets., 22.","DOI":"10.2174\/1871527321666220614110616"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Guo, P., Zhang, B., Zhao, J., Wang, C., Wang, Z., Liu, A., and Du, G. (2022). Medicine-Food Herbs against Alzheimer\u2019s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action. Molecules, 27.","DOI":"10.3390\/molecules27030901"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_23","unstructured":"Gibson, M.G., and Sharma, V. (2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5, American Psychiatric Association."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer\u2019s Disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Breijyeh, Z., and Karaman, R. (2020). Comprehensive Review on Alzheimer\u2019s Disease: Causes and Treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_26","first-page":"a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Frosch","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1073\/pnas.082107399","article-title":"Imaging the progression of Alzheimer pathology through the brain","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/brain\/awaa395","article-title":"Untangling the association of amyloid-\u03b2 and tau with synaptic and axonal loss in Alzheimer\u2019s disease","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-022-00523-1","article-title":"Alzheimer\u2019s disease\u2013the journey of a healthy brain into organ failure","volume":"17","author":"Golde","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease","volume":"18","author":"Kisler","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"688090","DOI":"10.3389\/fnins.2021.688090","article-title":"Blood-Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia","volume":"15","author":"Hussain","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sharma, C., Woo, H., and Kim, S.R. (2022). Addressing Blood\u2013Brain Barrier Impairment in Alzheimer\u2019s Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10040742"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s12035-017-0419-4","article-title":"RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration","volume":"55","author":"Brokos","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_34","first-page":"136","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: The devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Picca, A., Calvani, R., Coelho-Junior, H.J., Landi, F., Bernabei, R., and Marzetti, E. (2020). Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration. Antioxidants, 9.","DOI":"10.3390\/antiox9080647"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Patergnani, S., Bouhamida, E., Leo, S., Pinton, P., and Rimessi, A. (2021). Mitochondrial Oxidative Stress and \"Mito-Inflammation\": Actors in the Diseases. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020216"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"472932","DOI":"10.1155\/2012\/472932","article-title":"Antioxidant therapies for Alzheimer\u2019s disease","volume":"2012","author":"Feng","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jurcau, A. (2021). The Role of Natural Antioxidants in the Prevention of Dementia-Where Do We Stand and Future Perspectives. Nutrients, 13.","DOI":"10.3390\/nu13020282"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for primary prevention of Alzheimer\u2019s disease: An analysis of population-based data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.brainresrev.2007.09.004","article-title":"Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans","volume":"56","author":"Farooqui","year":"2007","journal-title":"Brain Res. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.3945\/jn.108.096016","article-title":"Docosahexaenoic acid and the aging brain","volume":"138","author":"Lukiw","year":"2008","journal-title":"J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.3945\/ajcn.113.071340","article-title":"Diet pattern and longevity: Do simple rules suffice? A commentary","volume":"100","author":"Jacobs","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.arr.2017.09.001","article-title":"Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition","volume":"40","author":"Calder","year":"2017","journal-title":"Ageing Res Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.arr.2017.12.004","article-title":"Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions","volume":"42","author":"Miquel","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., and Nencioni, A. (2017). Vitamin C, Aging and Alzheimer\u2019s Disease. Nutrients, 9.","DOI":"10.3390\/nu9070670"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"120166","DOI":"10.1016\/j.jns.2022.120166","article-title":"Mediterranean diet adherence, gut microbiota, and Alzheimer\u2019s or Parkinson\u2019s disease risk: A systematic review","volume":"434","author":"Solch","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112343","DOI":"10.1016\/j.biopha.2021.112343","article-title":"Composition of intestinal flora affects the risk relationship between Alzheimer\u2019s disease\/Parkinson\u2019s disease and cancer","volume":"145","author":"Hang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"942460","DOI":"10.3389\/fcimb.2022.942460","article-title":"A comparison of the composition and functions of the oral and gut microbiotas in Alzheimer\u2019s patients","volume":"12","author":"Chen","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","article-title":"Diet and Inflammation in Cognitive Ageing and Alzheimer\u2019s Disease","volume":"8","author":"McGrattan","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2016.09.017","article-title":"Vitamin E: Emerging aspects and new directions","volume":"102","author":"Galli","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lloret, A., Esteve, D., Monllor, P., Cervera-Ferri, A., and Lloret, A. (2019). The Effectiveness of Vitamin E Treatment in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040879"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Gugliandolo, A., Bramanti, P., and Mazzon, E. (2017). Role of Vitamin E in the Treatment of Alzheimer\u2019s Disease: Evidence from Animal Models. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122504"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"955878","DOI":"10.3389\/fnagi.2022.955878","article-title":"Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis","volume":"14","author":"Zhao","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/JAD-2000-2212","article-title":"Vitamin E Prevents Alzheimer\u2019s Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production","volume":"2","author":"Yatin","year":"2000","journal-title":"J. Alzheimers Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1523\/JNEUROSCI.5274-12.2013","article-title":"Amyloid-\u03b21-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1","volume":"33","author":"Scimemi","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1460-9568.1999.00408.x","article-title":"Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: Implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo","volume":"11","author":"Yamada","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-142-1-200501040-00110","article-title":"Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality","volume":"142","author":"Miller","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/jama.2013.282834","article-title":"Effect of vitamin E and memantine on functional decline in Alzheimer disease: The TEAM-AD VA cooperative randomized trial","volume":"311","author":"Dysken","year":"2014","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.trci.2016.08.003","article-title":"Insufficient evidence for vitamin E in Alzheimer\u2019s disease","volume":"2","author":"Hermann","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1001\/archinte.166.22.2462","article-title":"A randomized trial of vitamin E supplementation and cognitive function in women","volume":"166","author":"Kang","year":"2006","journal-title":"Arch Intern. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/0269881116680924","article-title":"Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology","volume":"31","author":"Holmes","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3233\/JAD-2009-1033","article-title":"Vitamin E paradox in Alzheimer\u2019s disease: It does not prevent loss of cognition and may even be detrimental","volume":"17","author":"Lloret","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa050151","article-title":"Alzheimer\u2019s Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of mild cognitive impairment","volume":"352","author":"Petersen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13024-021-00424-9","article-title":"New approaches to symptomatic treatments for Alzheimer\u2019s disease","volume":"16","author":"Cummings","year":"2021","journal-title":"Mol Neurodegener."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer\u2019s Association on \u201cThe Preclinical State of AD\u201d; July 23, 2015; Washington DC, USA. Preclinical Alzheimer\u2019s disease: Definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimer\u2019s Dement. J. Alzheimer\u2019s Assoc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1159\/000255105","article-title":"Vitamin E use is associated with improved survival in an Alzheimer\u2019s disease cohort","volume":"28","author":"Pavlik","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnagi.2015.00052","article-title":"Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA","volume":"7","author":"Dyall","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Avallone, R., Vitale, G., and Bertolotti, M. (2019). Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials. Int. J. Mol. Sci., 20.","DOI":"10.20944\/preprints201907.0289.v1"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1076-7460.2007.06696.x","article-title":"Cardiovascular risk factors for Alzheimer\u2019s disease","volume":"16","author":"Rosendorff","year":"2007","journal-title":"Am. J. Geriatr. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4065\/83.3.324","article-title":"Omega-3 fatty acids for cardioprotection","volume":"83","author":"Lee","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_73","first-page":"1","article-title":"Effects of omega-3 fatty acids on cognitive function with aging, dementia, and neurological diseases","volume":"114","author":"Maclean","year":"2005","journal-title":"Evid. Rep. Technol. Assess"},{"key":"ref_74","first-page":"79","article-title":"Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation","volume":"132","author":"Wassall","year":"2004","journal-title":"Chem. Phys. Lipids"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0306-4522(99)00107-4","article-title":"Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats","volume":"93","author":"Gamoh","year":"1999","journal-title":"Neuroscience"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neulet.2007.04.086","article-title":"Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults","volume":"421","author":"Conklin","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s11745-000-0646-3","article-title":"Fatty acid analysis of blood plasma of patients with Alzheimer\u2019s disease, other types of dementia, and cognitive impairment","volume":"35","author":"Conquer","year":"2000","journal-title":"Lipids"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1212\/01.wnl.0000278116.37320.52","article-title":"Dietary patterns and risk of dementia: The Three-City cohort study","volume":"69","author":"Raffaitin","year":"2007","journal-title":"Neurology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1079\/BJN2002804","article-title":"Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer\u2019s disease: A case-control study","volume":"89","author":"Tully","year":"2003","journal-title":"Br. J. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2009.03.026","article-title":"Selenoprotein P-expression, functions, and roles in mammals","volume":"1790","author":"Burk","year":"2009","journal-title":"Biochim Biophys. Acta."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.abb.2013.02.021","article-title":"Selenium homeostasis and antioxidant selenoproteins in brain: Implications for disorders in the central nervous system","volume":"536","author":"Steinbrenner","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neubiorev.2015.12.006","article-title":"RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis","volume":"62","author":"Ray","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/mds.23218","article-title":"Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed","volume":"25","author":"Shahar","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10534-014-9728-5","article-title":"Homeostasis of metals in the progression of Alzheimer\u2019s disease","volume":"27","year":"2014","journal-title":"Biometals"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"126541","DOI":"10.1016\/j.jtemb.2020.126541","article-title":"Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status-A four-year, prospective, randomised, double-blind placebo-controlled trial","volume":"61","author":"Alehagen","year":"2020","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Aaseth, J., Skalny, A.V., Roos, P.M., Alexander, J., Aschner, M., and Tinkov, A.A. (2021). Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179461"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","article-title":"Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer\u2019s disease: A randomized, double-blind, controlled trial","volume":"38","author":"Tamtaji","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"145703","DOI":"10.1088\/0957-4484\/26\/14\/145703","article-title":"The inhibitory effect of selenium nanoparticles on protein glycation in vitro","volume":"26","author":"Yu","year":"2015","journal-title":"Nanotechnology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11033-010-0362-1","article-title":"Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells","volume":"38","author":"Li","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"646518","DOI":"10.3389\/fnins.2021.646518","article-title":"Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer\u2019s Disease","volume":"15","author":"Zhang","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmet.2022.01.005","article-title":"Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging","volume":"34","author":"Leiter","year":"2022","journal-title":"Cell Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13311-018-0662-z","article-title":"Supranutritional sodium selenate supplementation delivers selenium to the central nervous system: Results from a randomized controlled pilot trial in Alzheimer\u2019s disease","volume":"16","author":"Cardoso","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s13311-019-00767-8","article-title":"Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders","volume":"16","author":"Singh","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/cns.13095","article-title":"Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761\u00ae","volume":"25","author":"Kandiah","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e042997","DOI":"10.1136\/bmjopen-2020-042997","article-title":"Comparison of effects of different dietary interventions on cognitive function in Alzheimer\u2019s disease: Protocol for systematic review and network meta-analysis","volume":"11","author":"Chen","year":"2021","journal-title":"BMJ Open."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00207454.2016.1155572","article-title":"Alzheimer\u2019s disease and diet: A systematic review","volume":"127","author":"Yusufov","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Gregory, J., Vengalasetti, Y.V., Bredesen, D.E., and Rao, R.V. (2021). Neuroprotective Herbs for the Management of Alzheimer\u2019s Disease. Biomolecules, 11.","DOI":"10.3390\/biom11040543"},{"key":"ref_98","first-page":"1","article-title":"Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia","volume":"11","author":"Alzobaidi","year":"2021","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Tsai, Y.-T., Kao, S.-T., and Cheng, C.-Y. (2022). Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911311"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1177\/1533317517715906","article-title":"Main Plant Extracts\u2019 Active Properties Effective on Scopolamine-Induced Memory Loss","volume":"32","author":"Balmus","year":"2017","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_101","first-page":"37","article-title":"Dietary supplements for cognitive impairment","volume":"45","year":"2017","journal-title":"Actas. Esp. Psiquiatr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3389\/fphar.2019.01688","article-title":"An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer\u2019s Patients","volume":"10","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Bonassi, S., Prinzi, G., Lamonaca, P., Russo, P., Paximadas, I., Rasoni, G., Rossi, R., Ruggi, M., Malandrino, S., and S\u00e1nchez-Flores, M. (2018). Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933\/Ginkgoselect\u00aePlus) in elderly: A randomised placebo-controlled clinical trial [GiBiEx]. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2080-5"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.2147\/CIA.S72728","article-title":"Efficacy and tolerability of Ginkgo biloba extract EGb 761\u00ae in dementia: A systematic review and meta-analysis of randomized placebo-controlled trials","volume":"9","author":"Gauthier","year":"2014","journal-title":"Clin. Interv. Aging."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/WNR.0000000000001223","article-title":"EGb 761 inhibits A\u03b21-42-induced neuroinflammatory response by suppressing P38 MAPK signaling pathway in BV-2 microglial cells","volume":"30","author":"Meng","year":"2019","journal-title":"Neuroreport"},{"key":"ref_106","first-page":"1","article-title":"Antioxidant properties of a Ginkgo biloba leaf extract (EGb 761) in animal models of Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"14","author":"Rojas","year":"2016","journal-title":"Curr. Top. Nutraceutical. Res"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Cefali, L.C., Ataide, J.A., Fernandes, A.R., Sanchez-Lopez, E., Sousa, I.M.O., Figueiredo, M.C., Ruiz, A.L.T.G., Foglio, M.A., Mazzola, P.G., and Souto, E.B. (2019). Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vin\u00edfera L.. Plants, 8.","DOI":"10.3390\/plants8110453"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/phrs.1999.0604","article-title":"Hydrogen peroxide-induced oxidative damage and apoptosis in cerebellar granule cells: Protection by Ginkgo biloba extract","volume":"41","author":"Wei","year":"2000","journal-title":"Pharmacol. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0300-483X(00)00200-6","article-title":"Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents","volume":"148","author":"Xin","year":"2000","journal-title":"Toxicology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijms11010107","article-title":"Ginkgo biloba extract in Alzheimer\u2019s disease: From action mechanisms to medical practice","volume":"11","author":"Shi","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_111","first-page":"195","article-title":"Ginkgo biloba L.\u2014Chemistry and activity","volume":"4","author":"Bodalski","year":"2006","journal-title":"Post\u0119py Fitoterapii (Adv. Phytother.)"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.phrs.2007.09.011","article-title":"Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761)","volume":"56","author":"Hauptmann","year":"2007","journal-title":"Pharmacol. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exger.2016.05.007","article-title":"EGb761 improves cognitive function and regulates inflammatory responses in the APP\/PS1 mouse","volume":"81","author":"Wan","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1096\/fj.06-7649com","article-title":"EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer\u2019s disease","volume":"21","author":"Tchantchou","year":"2007","journal-title":"FASEB J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"775034","DOI":"10.3389\/fphar.2021.775034","article-title":"The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer\u2019s Disease","volume":"4","author":"Nowak","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_116","first-page":"247","article-title":"Validated method for estimation of curcumin in turmeric powder","volume":"10","author":"Gantait","year":"2011","journal-title":"Ind. J. Trad. Knowledge."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2006-10101","article-title":"Curcuminoids enhance amyloid -beta uptake by macrophages of Alzheimer\u2019s disease patients","volume":"10","author":"Zhang","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0972-2327.40220","article-title":"The effect of curcumin (turmeric) on Alzheimer\u2019s disease: An overview","volume":"11","author":"Mishra","year":"2008","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_119","first-page":"469","article-title":"Curcumin inhibits dose-dependently and time-dependently neuroglial proliferation and growth","volume":"24","author":"Ambegaokar","year":"2003","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2174\/0929867325666180117112610","article-title":"Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer\u2019s Disease: A Systematic Review","volume":"17","author":"Freire","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jgr.2017.12.008","article-title":"Panax ginseng as an adjuvant treatment for Alzheimer\u2019s disease","volume":"42","author":"Kim","year":"2018","journal-title":"J Ginseng Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5142\/jgr.2013.37.100","article-title":"Effects of fermented ginseng on memory impairment and \u03b2-amyloid reduction in Alzheimer\u2019s disease experimental models","volume":"37","author":"Kim","year":"2013","journal-title":"J. Ginseng Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5142\/jgr.2011.35.4.421","article-title":"Comparative study of korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function","volume":"35","author":"Lee","year":"2011","journal-title":"J. Ginseng Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jep.2011.08.068","article-title":"Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro","volume":"138","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/WAD.0b013e31816c92e6","article-title":"Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease","volume":"22","author":"Lee","year":"2008","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1468-1331.2008.02157.x","article-title":"An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer\u2019s disease","volume":"15","author":"Heo","year":"2008","journal-title":"Eur. J. Neurol."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/45\/2\/98\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:28:38Z","timestamp":1760120918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/45\/2\/98"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":126,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["cimb45020098"],"URL":"https:\/\/doi.org\/10.3390\/cimb45020098","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]}}}