{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:15:29Z","timestamp":1785892529325,"version":"3.56.0"},"reference-count":74,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technology Research Council of Turkey (TUBITAK)","doi-asserted-by":"publisher","award":["215S650"],"award-info":[{"award-number":["215S650"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technology Research Council of Turkey (TUBITAK)","doi-asserted-by":"publisher","award":["2016\/BIL\/003"],"award-info":[{"award-number":["2016\/BIL\/003"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ege University Scientific Research Foundation","award":["215S650"],"award-info":[{"award-number":["215S650"]}]},{"name":"Ege University Scientific Research Foundation","award":["2016\/BIL\/003"],"award-info":[{"award-number":["2016\/BIL\/003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Celiac disease (CD) is an autoimmune enteropathy. Peroxiredoxins (PRDXs) are powerful antioxidant enzymes having an important role in significant cellular pathways including cell survival, apoptosis, and inflammation. This study aimed at investigating the expression levels of all PRDX isoforms (1\u20136) and their possible relationships with a transcription factor, HIF-1\u03b1, in the small intestinal tissue samples of pediatric CD patients. The study groups consisted of first-diagnosed CD patients (n = 7) and non-CD patients with functional gastrointestinal tract disorders as the controls (n = 7). The PRDXs and HIF-1\u03b1 expression levels were determined by using real-time PCR and Western blotting in duodenal biopsy samples. It was observed that the mRNA and protein expression levels of PRDX 5 were significantly higher in the CD patients, whereas the PRDX 1, -2, and -4 expressions were decreased in each case compared to the control group. No significant differences were detected in the PRDX 3 and PRDX 6 expressions. The expression of HIF-1\u03b1 was also significantly elevated in CD patients. These findings indicate, for the first time, that PRDXs, particularly PRDX 5, may play a significant role in the pathogenesis of CD. Furthermore, our results suggest that HIF-1\u03b1 may upregulate PRDX-5 transcription in the duodenal tissue of CD.<\/jats:p>","DOI":"10.3390\/cimb45020114","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T06:37:59Z","timestamp":1676875079000},"page":"1779-1793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peroxiredoxins and Hypoxia-Inducible Factor-1\u03b1 in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients"],"prefix":"10.3390","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-7555","authenticated-orcid":false,"given":"Fadime Ayd\u0131n","family":"K\u00f6se","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Celebi University, Izmir 35620, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun","family":"Pabuccuoglu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Ege University, Izmir 35040, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miray","family":"Karakoyun","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Faculty of Medicine, Ege University, Izmir 35040, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Aydogdu","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Faculty of Medicine, Ege University, Izmir 35040, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5409\/wjcp.v10.i4.53","article-title":"Celiac Disease in Children: A Review of the Literature","volume":"10","author":"Sahin","year":"2021","journal-title":"World J. 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