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The concept of ACM has recently been ex-tended to include right ventricular cardiomyopathy (ARVC), left ventricular cardiomyopathy (ALVC) and biventricular cardiomyopathy. ARVC is generally seen as the most common type of ACM. The pathogenesis of ACM involves mutation variants in desmosomal or non-desmosomal gene loci, as well as various external factors, such as intense exercise, stress and infections. Ion channel alterations, autophagy and non-desmosomal variants are also important components in the development of ACM. As clinical practice enters the era of precision therapy, it is important to review recent studies on these topics to better diagnose and treat the molecular phase of ACM.<\/jats:p>","DOI":"10.3390\/cimb45030141","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T03:59:32Z","timestamp":1678247972000},"page":"2186-2200","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advances in Ion Channel, Non-Desmosomal Variants and Autophagic Mechanisms Implicated in Arrhythmogenic Cardiomyopathy"],"prefix":"10.3390","volume":"45","author":[{"given":"Kexin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, China"},{"name":"Institution for Hypertension of Soochow University, Suzhou 215000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-4834","authenticated-orcid":false,"given":"Yufeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, China"},{"name":"Institution for Hypertension of Soochow University, Suzhou 215000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, China"},{"name":"Institution for Hypertension of Soochow University, Suzhou 215000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, China"},{"name":"Institution for Hypertension of Soochow University, Suzhou 215000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/ejhf.15","article-title":"Sex differences in cardiomyopathies","volume":"16","author":"Meyer","year":"2014","journal-title":"Eur. 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