{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:57:46Z","timestamp":1788983866216,"version":"build-2803163510"},"reference-count":164,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003983"],"award-info":[{"award-number":["82003983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022-JYB-JBZR-003"],"award-info":[{"award-number":["2022-JYB-JBZR-003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["P202201"],"award-info":[{"award-number":["P202201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Public Scientific Research Institution Fundamental Project","award":["82003983"],"award-info":[{"award-number":["82003983"]}]},{"name":"Central Public Scientific Research Institution Fundamental Project","award":["2022-JYB-JBZR-003"],"award-info":[{"award-number":["2022-JYB-JBZR-003"]}]},{"name":"Central Public Scientific Research Institution Fundamental Project","award":["P202201"],"award-info":[{"award-number":["P202201"]}]},{"name":"Open Project of Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education","award":["82003983"],"award-info":[{"award-number":["82003983"]}]},{"name":"Open Project of Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education","award":["2022-JYB-JBZR-003"],"award-info":[{"award-number":["2022-JYB-JBZR-003"]}]},{"name":"Open Project of Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education","award":["P202201"],"award-info":[{"award-number":["P202201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction\/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms.<\/jats:p>","DOI":"10.3390\/cimb45030152","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:52:13Z","timestamp":1678690333000},"page":"2351-2371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities"],"prefix":"10.3390","volume":"45","author":[{"given":"Zuomei","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-0498","authenticated-orcid":false,"given":"Yucai","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"Itc49","DOI":"10.7326\/AITC202104200","article-title":"Pulmonary Hypertension","volume":"174","author":"Poch","year":"2021","journal-title":"Ann. 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