{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:51:39Z","timestamp":1788184299952,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Hidradenitis suppurativa is a chronic inflammatory skin condition that affects the hair follicles in areas of the body with apocrine glands. The condition is characterized by recurrent, painful nodules, abscesses, and draining sinuses that can lead to scarring and disfigurement. In this present study, we provide a focused evaluation of recent developments in hidradenitis suppurativa research, including novel therapeutics and promising biomarkers that may facilitate clinical diagnosis and treatment. We conducted a systematic review of controlled trials, randomized controlled trials, meta-analyses, case reports, and Cochrane Review articles in accordance with the PRISMA guidelines. The Cochrane Library, PubMed, EMBASE, and Epistemonikos databases were queried via Title\/Abstract screen. Eligibility criteria included the following: (1) has a primary focus on hidradenitis suppurativa, (2) includes measurable outcomes data with robust comparators, (3) details the sample population, (4) English language, and (5) archived as full-text journal articles. A total of 42 eligible articles were selected for review. Qualitative evaluation identified numerous developments in our understanding of the disease\u2019s multiple potential etiologies, pathophysiology, and treatment options. It is important for individuals with hidradenitis suppurativa to work closely with a healthcare provider to develop a comprehensive treatment plan that addresses their individual needs and goals. To meet this objective, providers must keep current with developments in the genetic, immunological, microbiological, and environmental factors contributing to the disease\u2019s development and progression.<\/jats:p>","DOI":"10.3390\/cimb45050280","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T10:01:13Z","timestamp":1684404073000},"page":"4400-4415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management\u2014A Systematic Review"],"prefix":"10.3390","volume":"45","author":[{"given":"Michael Joseph","family":"Diaz","sequence":"first","affiliation":[{"name":"College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaliz","family":"Aflatooni","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-3969","authenticated-orcid":false,"given":"Parsa","family":"Abdi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Memorial University, St. Johns, NL A1B 3V6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sociology, Amherst College, Amherst, MA 01002, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Robert","family":"Anthony","sequence":"additional","affiliation":[{"name":"College of Medicine, The University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sphurti","family":"Neelam","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Farkouh","sequence":"additional","affiliation":[{"name":"Rush Medical College, Rush University, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine Thuy","family":"Tran","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Indiana, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Florida College of Medicine, Gainesville, FL 32606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-0248","authenticated-orcid":false,"given":"Mahtab","family":"Forouzandeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Florida College of Medicine, Gainesville, FL 32606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo H.","family":"Valdes Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Florida College of Medicine, Gainesville, FL 32606, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zouboulis, V.A., Zouboulis, K.C., and Zouboulis, C.C. 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