{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:21:06Z","timestamp":1760149266451,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sigrid Jus\u00e9lius Foundation"},{"name":"Finnish Medical Foundation"},{"name":"Academy of Finland"},{"name":"Finnish Cancer Foundation"},{"name":"P\u00e4ivikki and Sakari Sohlberg Foundation"},{"name":"The Government Special Foundation (EVO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The host factors that influence father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period. Altogether, 134 father\u2013newborn pairs from the Finnish Family HPV Study were included. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples were collected from their offspring at delivery and postpartum on day 3 and during 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the association of the father\u2013child HLA-G allele and genotype concordance with the father\u2013child HPV prevalence and concordance at birth and during follow-up. HLA-G allele G*01:01:03 concordance was associated with the father\u2019s urethral and child\u2019s oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95% CI: 1.24\u2013232.22). HLA-G allele G*01:04:01 concordance increased the father\u2019s oral and child\u2019s postpartum oral any- and HR-HPV concordance with an OR value of 7.50 (95% CI: 1.47\u201338.16) and OR value of 7.78 (95% CI: 1.38\u201343.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father\u2013child pairs at birth or postpartum. To conclude, the HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring.<\/jats:p>","DOI":"10.3390\/cimb45070366","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T02:14:48Z","timestamp":1689214488000},"page":"5798-5810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA-G Alleles Impact the Perinatal Father\u2013Child HPV Transmission"],"prefix":"10.3390","volume":"45","author":[{"given":"Nelli T.","family":"Suominen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, 20520 Turku, Finland"},{"name":"Department of Obstetrics and Gynecology, Vaasa Central Hospital, 65130 Vaasa, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Roger","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et d\u2019Immunologie et Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H2X 0A9, Canada"},{"name":"Department of Microbiology, Infectious Diseases and Immunology, University of Montreal, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Faucher","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et d\u2019Immunologie et Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari J.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seija E.","family":"Gr\u00e9nman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina M.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Radiology, University of Turku, 20520 Turku, Finland"},{"name":"Department of Pathology, Turku University Hospital, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-363X","authenticated-orcid":false,"given":"Karolina","family":"Louvanto","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Radiology, University of Turku, 20520 Turku, Finland"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Obstetrics and Gynecology, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"K1","DOI":"10.1016\/j.vaccine.2008.05.064","article-title":"Epidemiology and Natural History of Human Papillomavirus Infections and Type-Specific Implications in Cervical Neoplasia","volume":"26","author":"Bosch","year":"2008","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.22527","article-title":"Human Papillomavirus Type Distribution in Invasive Cervical Cancer and High-Grade Cervical Lesions: A Meta-Analysis Update","volume":"121","author":"Smith","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide Burden of Cancer Attributable to HPV by Site, Country and HPV Type","volume":"141","author":"Plummer","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hed.20491","article-title":"Juvenile Recurrent Respiratory Papillomatosis: Still a Mystery Disease with Difficult Management","volume":"29","author":"Stamataki","year":"2007","journal-title":"Head. Neck"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijporl.2013.11.036","article-title":"Risk Factors for the Development and Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis: A Systematic Review","volume":"78","author":"Niyibizi","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1086\/657321","article-title":"Cervical Human Papillomavirus Prevalence in 5 Continents: Meta-Analysis of 1 Million Women with Normal Cytological Findings","volume":"202","author":"Bruni","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/01443615.2015.1030606","article-title":"Effect of Mode of Delivery on Vertical Human Papillomavirus Transmission\u2014A Meta-Analysis","volume":"36","author":"Chatzistamatiou","year":"2016","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/CEJ.0b013e3283592c46","article-title":"Transmission of Carcinogenic Human Papillomavirus Types from Mother to Child: A Meta-Analysis of Published Studies","volume":"22","author":"Merckx","year":"2013","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1590\/S0102-311X2005000400003","article-title":"Vertical Transmission of the Human Papillomavirus: A Systematic Quantitative Review","volume":"21","author":"Medeiros","year":"2005","journal-title":"Cad. Saude Publica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1600-0463.2010.02620.x","article-title":"Current Concepts on Human Papillomavirus Infections in Children","volume":"118","year":"2010","journal-title":"APMIS"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1071\/SH15089","article-title":"Penises Not Required: A Systematic Review of the Potential for Human Papillomavirus Horizontal Transmission That Is Non-Sexual or Does Not Include Penile Penetration","volume":"13","author":"Liu","year":"2016","journal-title":"Sex. Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00404-018-4787-4","article-title":"Intrauterine HPV Transmission: A Systematic Review of the Literature","volume":"298","author":"Zouridis","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1128\/JCM.43.1.376-381.2005","article-title":"Transmission of High-Risk Human Papillomavirus (HPV) between Parents and Infant: A Prospective Study of HPV in Families in Finland","volume":"43","author":"Rintala","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Skoczy\u0144ski, M., Go\u017adzicka-J\u00f3zefiak, A., and Kwa\u015bniewska, A. (2019). Co-Occurrence of Human Papillomavirus (HPV) in Newborns and Their Parents. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4503-4"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Niyibizi, J., Mayrand, M.H., Audibert, F., Monnier, P., Brassard, P., Laporte, L., Lacaille, J., Zahreddine, M., B\u00e9dard, M.J., and Girard, I. (2021). Association between Human Papillomavirus Infection among Pregnant Women and Preterm Birth. JAMA Netw. Open, 4.","DOI":"10.1001\/jamanetworkopen.2021.25308"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1086\/340421","article-title":"Human Papillomavirus DNA Is Found in the Vas Deferens","volume":"185","author":"Rintala","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humrep\/det453","article-title":"Prevalence of Human Papillomaviruses in Semen: A Systematic Review and Meta-Analysis","volume":"29","author":"Laprise","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.ai.2015.04.001","article-title":"HLA-G: An Immune Checkpoint Molecule","volume":"127","author":"Carosella","year":"2015","journal-title":"Adv. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lin, A., and Yan, W.H. (2019). Intercellular Transfer of HLA-G: Its Potential in Cancer Immunology. Clin. Transl. Immunol., 8.","DOI":"10.1002\/cti2.1077"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Amiot, L., Vu, N., and Samson, M. (2014). Immunomodulatory Properties of HLA-G in Infectious Diseases. J. Immunol. Res., 2014.","DOI":"10.1155\/2014\/298569"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Rizzo, R., Bortolotti, D., Bolzani, S., and Fainardi, E. (2014). HLA-G Molecules in Autoimmune Diseases and Infections. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00592"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00018-010-0580-7","article-title":"Implications of the Polymorphism of HLA-G on Its Function, Regulation, Evolution and Disease Association","volume":"68","author":"Donadi","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1096\/fj.04-2078rev","article-title":"HLA-G and Immune Tolerance in Pregnancy","volume":"19","author":"Hunt","year":"2005","journal-title":"FASEB J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1097\/00002030-200111090-00019","article-title":"Mother-to-Child Discordance in HLA-G Exon 2 Is Associated with a Reduced Risk of Perinatal HIV-1 Transmission","volume":"15","author":"Aikhionbare","year":"2001","journal-title":"AIDS"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.humimm.2012.11.023","article-title":"HLA-G and Mother-Child Perinatal HIV Transmission","volume":"74","author":"Luo","year":"2013","journal-title":"Hum. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1097\/QAD.0b013e32832f8104","article-title":"HLA-G 3\u2032 UTR Haplotypes and HIV Vertical Transmission","volume":"23","author":"Segat","year":"2009","journal-title":"AIDS"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Aikhionbare, F.O., Kumaresan, K., Shamsa, F., and Bond, V.C. (2006). HLA-G DNA Sequence Variants and Risk of Perinatal HIV-I Transmission. AIDS Res. Ther., 3.","DOI":"10.1186\/1742-6405-3-28"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/QAD.0b013e32832027bf","article-title":"Association between HLA-G 3\u2032UTR 14-Bp Polymorphism and HIV Vertical Transmission in Brazilian Children","volume":"23","author":"Fabris","year":"2009","journal-title":"AIDS"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.meegid.2014.12.021","article-title":"Maternal Human Leukocyte Antigen-G (HLA-G) Genetic Variants Associate with in Utero Mother-to-Child Transmission of HIV-1 in Black South Africans","volume":"30","author":"Hong","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/039463200601900213","article-title":"Hierarchy of Baby-Linked Immunogenetic Risk Factors in the Vertical Transmission of Hepatitis C Virus","volume":"19","author":"Martinetti","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.humimm.2018.03.002","article-title":"HLA-G and Vertical Mother-to-Child Transmission of Human Papillomavirus Infection","volume":"79","author":"Louvanto","year":"2018","journal-title":"Hum. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1086\/498114","article-title":"High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study","volume":"41","author":"Rintala","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1086\/653826","article-title":"Genotype-Specific Persistence of Genital Human Papillomavirus (HPV) Infections in Women Followed for 6 Years in the Finnish Family HPV Study","volume":"202","author":"Louvanto","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JCM.44.2.504-512.2006","article-title":"Bead-Based Multiplex Genotyping of Human Papillomaviruses","volume":"44","author":"Schmitt","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.humimm.2011.01.010","article-title":"Human Leukocyte Antigen (HLA)-E and HLA-G Polymorphisms in Human Papillomavirus Infection Susceptibility and Persistence","volume":"72","author":"Ferguson","year":"2011","journal-title":"Hum. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1158\/0008-5472.CAN-09-4179","article-title":"A Population-Based Prospective Study of Carcinogenic Human Papillomavirus Variant Lineages, Viral Persistence, and Cervical Neoplasia","volume":"70","author":"Schiffman","year":"2010","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/cam4.538","article-title":"Early-Life Exposures to Infectious Agents and Later Cancer Development","volume":"4","author":"Vedham","year":"2015","journal-title":"Cancer Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/01.OLQ.0000105327.40288.DB","article-title":"Human Papillomavirus Prevalence and Types in Newborns and Parents: Concordance and Modes of Transmission","volume":"31","author":"Smith","year":"2004","journal-title":"Sex. Transm. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Syrj\u00e4nen, S., Rintala, M., Sarkola, M., Willberg, J., Rautava, J., Koskimaa, H., Paaso, A., Syrj\u00e4nen, K., Gr\u00e9nman, S., and Louvanto, K. (2021). Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland. Emerg. Infect. Dis., 27.","DOI":"10.3201\/eid2703.202721"},{"key":"ref_40","first-page":"D948","article-title":"IPD-IMGT\/HLA Database","volume":"48","author":"Robinson","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Castelli, E.C., Ramalho, J., Porto, I.O.P., Lima, T.H.A., Fel\u00edcio, L.P., Sabbagh, A., Donadi, E.A., and Mendes-Junior, C.T. (2014). Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00476"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10096-021-04362-8","article-title":"The Association of HLA-G Polymorphism with Oral and Genital HPV Infection in Men","volume":"41","author":"Suominen","year":"2022","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Syrj\u00e4nen, S., Waterboer, T., Rintala, M., Pawlita, M., Syrj\u00e4nen, K., Louvanto, K., and Grenman, S. (2022). Maternal HPV-Antibodies and Seroconversion to HPV in Children during the First 3 Years of Life. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-06343-z"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Koskimaa, H.M., Paaso, A.E., Welters, M.J.P., Gr\u00e9nman, S.E., Syrj\u00e4nen, K.J., van der Burg, S.H., and Syrj\u00e4nen, S.M. (2014). Human Papillomavirus 16 E2-, E6- and E7-Specific T-Cell Responses in Children and Their Mothers Who Developed Incident Cervical Intraepithelial Neoplasia during a 14-Year Follow-up of the Finnish Family HPV Cohort. J. Transl. Med., 12.","DOI":"10.1186\/1479-5876-12-44"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Koskimaa, H.M., Paaso, A., Welters, M.J.P., Gr\u00e9nman, S., Syrj\u00e4nen, K., Burg, S.H., and Syrj\u00e4nen, S. (2015). Human Papillomavirus 16-Specific Cell-Mediated Immunity in Children Born to Mothers with Incident Cervical Intraepithelial Neoplasia (CIN) and to Those Constantly HPV Negative. J. Transl. Med., 13.","DOI":"10.1186\/s12967-015-0733-4"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s10096-017-2958-z","article-title":"The Presence of Human Papillomavirus (HPV) in Placenta and\/or Cord Blood Might Result in Th2 Polarization","volume":"36","author":"Koskimaa","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/45\/7\/366\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:11:28Z","timestamp":1760127088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/45\/7\/366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,12]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["cimb45070366"],"URL":"https:\/\/doi.org\/10.3390\/cimb45070366","relation":{},"ISSN":["1467-3045"],"issn-type":[{"type":"electronic","value":"1467-3045"}],"subject":[],"published":{"date-parts":[[2023,7,12]]}}}