{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:53:47Z","timestamp":1779173627458,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPESP (Research Support Foundation of the State of S\u00e3o Paulo-SP\u2014Brazil","award":["2017\/10264-6"],"award-info":[{"award-number":["2017\/10264-6"]}]},{"name":"Abbott Diagnostics","award":["2017\/10264-6"],"award-info":[{"award-number":["2017\/10264-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Parvovirus B19 infection is associated with a wide range of clinical manifestations, from asymptomatic to severe neurological disorders. Its major clinical symptoms, fever and rash, are common to multiple viruses, and laboratory tests to detect B19 are frequently not available. Thus, the impact of B19 on public health remains unclear. We report the case of a 38-day old girl admitted to S\u00e3o Paulo Clinical Hospital, Brazil, with an initial diagnosis of bacterial meningitis, seizures, and acute hydrocephalus. Antibiotic therapy was maintained for one week after admission and discontinued after negative laboratory results were obtained. Nine days after symptoms onset, a cerebral spinal fluid (CSF) sample revealed persistent pleocytosis. The complete B19 complete genome was subsequently identified in her CSF by a metagenomic next-generation sequencing approach. This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.<\/jats:p>","DOI":"10.3390\/cimb45090439","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:20:55Z","timestamp":1692696055000},"page":"6958-6966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus\u00a0influenzae Meningitis in a Newborn"],"prefix":"10.3390","volume":"45","author":[{"given":"Noely Evangelista","family":"Ferreira","sequence":"first","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-5177","authenticated-orcid":false,"given":"Antonio C.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esper G.","family":"Kallas","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia G. T.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-6868","authenticated-orcid":false,"given":"Ana Carolina S.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-3095","authenticated-orcid":false,"given":"Layla","family":"Honorato","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heuder G. O.","family":"Pai\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia H.","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewton","family":"de M. Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina F.","family":"C\u00f4rtes","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia F.","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania R. T.","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica LIM 15, Hospital da Clinicas da, Faculdade de Medicina da, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Department of Obstetrics and Gynecology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-8108","authenticated-orcid":false,"given":"Maria C.","family":"Mendes-Correa","sequence":"additional","affiliation":[{"name":"Departamento de Molestias Infecciosas e Parasitarias, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1099\/jgv.0.001212","article-title":"ICTV Virus Taxonomy Profile: Parvoviridae","volume":"100","author":"Cotmore","year":"2019","journal-title":"J. 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