{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:51:12Z","timestamp":1782363072339,"version":"3.54.5"},"reference-count":94,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Cuncil of La Reunion","award":["RE0002581"],"award-info":[{"award-number":["RE0002581"]}]},{"name":"FEDER (European Regional Development Funds): Feder European Project RAFALE D2016009986-AAP-RDI 2015-1a\u2014Action 1.09\u2014Synergie","award":["RE0002581"],"award-info":[{"award-number":["RE0002581"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Sweet potato (SP), Ipomoea batatas Lam, belongs to the Convolvulaceae family. It produces edible storage roots. Currently, orange varieties contribute to improving food systems and managing vitamin A deficiency. Processing of this food crop into flour allows better conservation. However, nutrition health data regarding SP flour obtained by green extraction remains scarce. In this study, we therefore explored its phytochemistry and its associated bioactivity potential for human health. We analyzed the nutritional composition of orange flesh sweet potato (OFSP) flour and assessed the antioxidant (free radical scavenging) and immunomodulatory (on inflammatory murine macrophages) properties of the extract. More specifically, we measured the impact of OFSP flour extract on mediators such as Nitric Oxide (NO) and the production of pro-inflammatory cytokines such as Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha), Monocyte Chemoattractant Protein-1 (MCP-1), and Prostaglandin-E2 (PGE-2). Our results indicated significant fiber, mineral, beta-carotene, and polyphenols content in the extracts, and antioxidant and immunomodulatory bioactivities were also demonstrated with a concentration-dependent inhibition of cytokine production. Taken together, our results suggest that Ipomoea batatas flour could, in addition to being a good source of energy and beta-carotene provitamin A, constitute a food of interest for the prophylaxis of metabolic diseases associated with an underlying low-grade inflammatory state.<\/jats:p>","DOI":"10.3390\/cimb45090440","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:30:12Z","timestamp":1692786612000},"page":"6967-6985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts Obtained by Green Extraction"],"prefix":"10.3390","volume":"45","author":[{"given":"Imane","family":"Boukhers","sequence":"first","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Morel","sequence":"additional","affiliation":[{"name":"Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS-Universit\u00e9 de Montpellier-Universit\u00e9 Paul-Val\u00e9ry Montpellier-EPHE-IRD, 34093 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-0609","authenticated-orcid":false,"given":"Joelle","family":"Kongolo","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-4925","authenticated-orcid":false,"given":"Romain","family":"Domingo","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-6707","authenticated-orcid":false,"given":"Adrien","family":"Servent","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Ollier","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hippolyte","family":"Kodja","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-5782","authenticated-orcid":false,"given":"Thomas","family":"Petit","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Universit\u00e9 de La R\u00e9union, 34093 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-5502","authenticated-orcid":false,"given":"Patrick","family":"Poucheret","sequence":"additional","affiliation":[{"name":"Qualisud, Univ Montpellier, Avignon Universit\u00e9, CIRAD, Institut Agro, IRD, Universit\u00e9 de La R\u00e9union, 97400 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12678","DOI":"10.7717\/peerj.12678","article-title":"A Review of Starch Biosynthesis in Cereal Crops and Its Potential Breeding Applications in Rice (Oryza sativa L.)","volume":"9","author":"Li","year":"2021","journal-title":"Peer J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14964","DOI":"10.1073\/pnas.1610359113","article-title":"Can Sub-Saharan Africa Feed Itself?","volume":"113","author":"Wolf","year":"2016","journal-title":"Proc. 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