{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:21:03Z","timestamp":1790364063372,"version":"4.1.0"},"reference-count":126,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Programs of China","award":["2022YFC2603801"],"award-info":[{"award-number":["2022YFC2603801"]}]},{"name":"National Key Research and Development Programs of China","award":["202208170046"],"award-info":[{"award-number":["202208170046"]}]},{"name":"Funding for Kunlun Talented People of Qinghai Province, High-end Innovation and Entrepreneurship Talents-Leading Talents","award":["2022YFC2603801"],"award-info":[{"award-number":["2022YFC2603801"]}]},{"name":"Funding for Kunlun Talented People of Qinghai Province, High-end Innovation and Entrepreneurship Talents-Leading Talents","award":["202208170046"],"award-info":[{"award-number":["202208170046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The SARS coronavirus 2 (SARS-CoV-2) is the causative agent of the 2019 coronavirus disease (COVID-19) pandemic that has claimed the lives of 6.9 million people and infected over 765 million. It has become a major worldwide health problem and is also known to cause abnormalities in various systems, including the hematologic system. COVID-19 infection primarily affects the lower respiratory tract and can lead to a cascade of events, including a cytokine storm, intravascular thrombosis, and subsequent complications such as arterial and venous thromboses. COVID-19 can cause thrombocytopenia, lymphopenia, and neutrophilia, which are associated with worse outcomes. Prophylactic anticoagulation is essential to prevent complications and death rates associated with the virus\u2019s effect on the coagulation system. It is crucial to recognize these complications early and promptly start therapeutic anticoagulation to improve patient outcomes. While rare, COVID-19-induced disseminated intravascular coagulation (DIC) exhibits some similarities to DIC induced by sepsis. Lactate dehydrogenase (LDH), D-dimer, ferritin, and C-reactive protein (CRP) biomarkers often increase in serious COVID-19 cases and poor prognosis. Understanding the pathophysiology of the disease and identifying risk factors for adverse outcomes is critical for effective management of COVID-19.<\/jats:p>","DOI":"10.3390\/cimb45090453","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:57:35Z","timestamp":1693205855000},"page":"7161-7182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pathological Effects of SARS-CoV-2 Associated with Hematological Abnormalities"],"prefix":"10.3390","volume":"45","author":[{"family":"Shama","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-8823","authenticated-orcid":false,"given":"Asif","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang 212013, China"},{"name":"School of Material Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","unstructured":"(2023, July 18). 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