{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:53:43Z","timestamp":1783976023605,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Brown Adipose Tissue (BAT) is considered beneficial in diabetes and obesity, but it can also have negative effects such as its implication in tumours\u2019 pathogenesis and the development of Cancer-induced Cachexia. Since 18F-FDG PET\/CT is a common molecular imaging modality used in cancer assessment, we aim to study the 18F-FDG BAT biodistribution in oncological patients and look for possible correlations between BAT activity and different malignancies as well as the patient\u2019s weight status. After analysing the total number of oncological 18F-FDG PET\/CT scans between 2017 and 2021, we selected patients with active BAT. Based on their BMI, the selected patients were divided into nonobese (NO) vs. overweight and obese (OOB). OOB SUVmaxlean body mass(LBM) had the highest mean values in supraclavicular, latero-cervical, and paravertebral vs. mediastinal and latero-thoracic localisations in NO. BMI was positively correlated with latero-cervical and supraclavicular SUVmax(LBM) but negatively correlated with latero-thoracic and abdominal SUVmax(LBM). Considering the age of the patients, SUVmax(LBM) decreases in the latero-cervical, paravertebral, and abdominal regions. In addition, the males presented lower SUVmax(LBM) values. SUVmax(LBM) was not affected by the treatment strategy or the oncological diagnosis. To conclude, it is mandatory to take into consideration the BAT particularities and effects on weight status in order to optimise the clinical management of oncological patients.<\/jats:p>","DOI":"10.3390\/cimb45100499","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:24:44Z","timestamp":1695889484000},"page":"7891-7914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Off the Beaten Path in Oncology: Active Brown Adipose Tissue by Virtue of Molecular Imaging"],"prefix":"10.3390","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-6473","authenticated-orcid":false,"given":"Wael","family":"Jalloul","sequence":"first","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-8594","authenticated-orcid":false,"given":"Mihaela","family":"Moscalu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Interdisciplinarity, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Moscalu","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, Cell Matrix Biology and Regenerative Medicine, The University of Manchester, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Jalloul","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena Cristina","family":"Grierosu","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences (Pathophysiology), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cati Raluca","family":"Stolniceanu","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Ghizdovat","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-1691","authenticated-orcid":false,"given":"Veronica","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences (Pathophysiology), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Pavaleanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cipriana","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Medical Physics-Nuclear Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"North East Regional Innovative Cluster for Structural and Molecular Imaging (Imago-Mol), 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.4158\/EP15870.RA","article-title":"Adiposity-related cancer and functional imaging of brown adipose tissue","volume":"21","author":"Santhanam","year":"2015","journal-title":"Endocr. Pract."},{"key":"ref_2","first-page":"e58469","article-title":"Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET\/CT","volume":"146","author":"Kim","year":"2019","journal-title":"J. Vis. 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