{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:07:51Z","timestamp":1791900471808,"version":"4.3.4"},"reference-count":187,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The significance of oxidative stress in the pathophysiology of male reproductive processes has been closely studied in the last two decades. Recently, it has become clear that oxidative stress can lead to numerous pathological conditions during female reproductive processes as well, contributing to the development of endometriosis, polycystic ovary syndrome and various forms of infertility. During pregnancy, physiological generation of reactive oxygen species (ROS) occurs in association with several developmental processes including oocyte maturation and implantation. An overproduction of ROS can lead to disturbances in fetal development and increases the risk for missed abortion, intrauterine growth restriction, pre-eclampsia, premature delivery and gestational diabetes. Our review focuses on the etiological role of the disrupted oxidant\u2013antioxidant system during human gestation as it relates to adverse pregnancy outcomes.<\/jats:p>","DOI":"10.3390\/cimb45100511","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:58:57Z","timestamp":1696420737000},"page":"8091-8111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Disrupted Balance of the Oxidant\u2013Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes"],"prefix":"10.3390","volume":"45","author":[{"given":"J\u00f3zsef G\u00e1bor","family":"Jo\u00f3","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kornya","sequence":"additional","affiliation":[{"name":"Central Hospital of South Pest National Institute of Hematology and Infectious Diseases, 1476 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12958-018-0391-5","article-title":"A novel and compact review on the role of oxidative stress in female reproduction","volume":"20","author":"Lu","year":"2018","journal-title":"Reprod. 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