{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:40:54Z","timestamp":1789497654806,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Institute for Advanced of Technology","award":["P0017908"],"award-info":[{"award-number":["P0017908"]}]},{"name":"Korea Institute for Advanced of Technology","award":["NRF-2019R1I1A2A01063598"],"award-info":[{"award-number":["NRF-2019R1I1A2A01063598"]}]},{"name":"National Research Foundation of Korea Grant","award":["P0017908"],"award-info":[{"award-number":["P0017908"]}]},{"name":"National Research Foundation of Korea Grant","award":["NRF-2019R1I1A2A01063598"],"award-info":[{"award-number":["NRF-2019R1I1A2A01063598"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Astragalus membranaceus and Cinnamomum cassia are used as spices and flavorful ingredients, or medicinal herbs with pharmacological effects. In this study, the hair-growth-promoting effects of the YH complex, a newly developed formula consisting of membranaceus and C. cassia, are investigated with the prediction of its molecular mechanism. The target gene of the YH complex was about 74.8% overlapped with the gene set of \u2018Hair growth\u2019 on the GO Biological Process database. The oral administration of the YH complex promoted hair regrowth and increased hair-shaft thickness in depilated hair loss mice. In addition, the anagen\/telogen hair follicle ratio was significantly increased by the YH complex. The growth factors affecting the growth of hair follicles were dose-dependently increased by treatment with the YH complex. The Wnt\/\u03b2-catenin signaling pathway expressions in skin tissues were apparently increased by the administration of the YH complex. In conclusion, the YH complex consisting of A. membranaceus and C. cassia induced hair follicle differentiation and preserved the growing-anagen phase by increasing growth factors and the Wnt\/\u03b2-catenin signaling pathway, leading to the restoration of hair loss. The YH complex can be a remedy for hair loss diseases, such as alopecia areata, androgenetic alopecia, telogen effluvium, and chemotherapy-induced alopecia.<\/jats:p>","DOI":"10.3390\/cimb45110541","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:22:15Z","timestamp":1698304935000},"page":"8607-8621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt\/\u03b2-Catenin Signaling Pathway"],"prefix":"10.3390","volume":"45","author":[{"given":"Mi Hye","family":"Kim","sequence":"first","affiliation":[{"name":"College of Korean Medicine, Woosuk University, Wanju 55338, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Chul","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0058-9279","authenticated-orcid":false,"given":"Hee Kyung","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-2386","authenticated-orcid":false,"given":"Woong Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"ref_1","first-page":"377","article-title":"The Diagnosis and Treatment of Hair and Scalp Diseases","volume":"113","author":"Wolff","year":"2016","journal-title":"Dtsch. 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