{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:17Z","timestamp":1787317757537,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Fundamental Research Funds for Central Public Welfare Research Institutes","award":["2023CZ-3"],"award-info":[{"award-number":["2023CZ-3"]}]},{"name":"The Fundamental Research Funds for Central Public Welfare Research Institutes","award":["2022CZ-11"],"award-info":[{"award-number":["2022CZ-11"]}]},{"name":"The Fundamental Research Funds for Central Public Welfare Research Institutes","award":["2023CZ-3"],"award-info":[{"award-number":["2023CZ-3"]}]},{"name":"The Fundamental Research Funds for Central Public Welfare Research Institutes","award":["2022CZ-11"],"award-info":[{"award-number":["2022CZ-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Changes in intracellular nicotinamide adenine dinucleotide (NAD+) levels have been observed in various disease states. A decrease in NAD+ levels has been noted following spinal cord injury (SCI). Nicotinamide riboside (NR) serves as the precursor of NAD+. Previous research has demonstrated the anti-inflammatory and apoptosis-reducing effects of NR supplements. However, it remains unclear whether NR exerts a similar role in mice after SCI. The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL\/6J mice aged 6\u20138 weeks were intraperitoneally administered with 500 mg\/kg\/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis\/recruitment of leukocytes, leading to reduced levels of inflammatory factors such as IL-1\u03b2, TNF-\u03b1, and IL-22 in the injured area. Moreover, NR supplementation notably enhanced the survival of neurons and synapses within the injured area, ultimately resulting in improved motor functions after SCI. Therefore, our research findings demonstrated that NR supplementation had inhibitory effects on leukocyte chemotaxis, anti-inflammatory effects, and could significantly improve the immune micro-environment after SCI, thereby promoting neuronal survival and ultimately enhancing the recovery of motor functions after SCI. NR supplementation showed promise as a potential clinical treatment strategy for SCI.<\/jats:p>","DOI":"10.3390\/cimb46020082","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T11:25:55Z","timestamp":1706786755000},"page":"1291-1307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice"],"prefix":"10.3390","volume":"46","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Jing","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ke","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Rehabilitation Medicine, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China"},{"name":"School of Rehabilitation, Capital Medical University, Beijing 100068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. 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