{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:04:10Z","timestamp":1772726650596,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Ophthalmologic Society (DOG\u2014Deutsche Ophthalmologische Gesellschaft)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The orbital manifestation of a solitary fibrous tumor (SFT) is exceptionally rare and poses specific challenges in diagnosis and treatment. Its rather exceptional behavior among all SFTs comprises a high tendency towards local recurrence, but it rarely culminates in metastatic disease. This raises the question of prognostic factors in orbital SFTs (oSFTs). Telomerase reverse transcriptase (TERT)-promoter mutations have previously been linked to an unfavorable prognosis in SFTs of other locations. We analyzed the prevalence of TERT promoter mutations of SFTs in the orbital compartment. We performed a retrospective, descriptive clinico-histopathological analysis of nine cases of oSFTs between the years of 2017 and 2021. A TERT promoter mutation was present in one case, which was classified with intermediate metastatic risk. Local recurrence or progress occurred in six cases after primary resection; no distant metastases were reported. Multimodal imaging repeatedly showed particular morphologic patterns, including tubular vascular structures and ADC reduction. The prevalence of the TERT promoter mutation in oSFT was 11%, which is similar to the prevalence of extra-meningeal SFTs of the head and neck and lower than that in other extra-meningeal compartments. In the present study, the TERT promoter mutation in oSFT manifested in a case with an unfavorable prognosis, comprising aggressive local tumor growth, local recurrence, and eye loss.<\/jats:p>","DOI":"10.3390\/cimb46020095","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T08:16:52Z","timestamp":1707725812000},"page":"1467-1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-6943","authenticated-orcid":false,"given":"David Sinan","family":"Koca","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kolpakov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-1321","authenticated-orcid":false,"given":"Jana","family":"Ihlow","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2014Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Berlin Institute of Health Charit\u00e9 Clinician Scientist Program, Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin Institute of Health Biomedical Innovation Academy, Anna-Louisa-Karsch-Str., 210178 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"von Laffert","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2014Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Department of Diagnostics, Institute of Pathology, Universit\u00e4tsklinikum Leipzig A\u00f6R, Liebigstra\u00dfe 26, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Erb-Eigner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-1881","authenticated-orcid":false,"given":"Hermann","family":"Herbst","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vivantes Hospital Neuk\u00f6lln, Vivantes Netzwerk f\u00fcr Gesundheit GmbH Berlin, Rudower Stra\u00dfe 48, 12351 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Kriese","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vivantes Hospital Neuk\u00f6lln, Vivantes Netzwerk f\u00fcr Gesundheit GmbH Berlin, Rudower Stra\u00dfe 48, 12351 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonille","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2014Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Edinger Institute, Institute of Neurology, University of Frankfurt am Main, 60528 Frankfurt am Main, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\u2013Mainz, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute (FCI), 60596 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckart","family":"Bertelmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"ref_1","first-page":"1385978","article-title":"Clinical Presentation, Natural History, and Therapeutic Approach in Patients with Solitary Fibrous Tumor: A Retrospective Analysis","volume":"2020","author":"Timmermans","year":"2020","journal-title":"Sarcoma"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000658-194207000-00004","article-title":"Hemangiopericytoma: A vascular tumor featuring zimmermann\u2019s pericytes","volume":"116","author":"Stout","year":"1942","journal-title":"Ann. 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