{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:52:42Z","timestamp":1760143962735,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["KJQN202100411","2016QNRC001"],"award-info":[{"award-number":["KJQN202100411","2016QNRC001"]}]},{"name":"Young Elite Scientists Sponsorship Program","award":["KJQN202100411","2016QNRC001"],"award-info":[{"award-number":["KJQN202100411","2016QNRC001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The tumor metastasis suppressor gene CD82\/KAI1 has been demonstrated to impact human trophoblast invasion and migration. Communication between trophoblasts and decidual stromal cells plays a crucial role in controlling the normal invasiveness of trophoblasts. However, whether CD82\/KAI1 is involved in decidualization and what role it plays remain unclear. CD82\/KAI1 demonstrates specific spatiotemporal expression patterns in stromal cells undergoing decidualization during pregnancy. This is observed in both naturally pregnant females post-implantation and pseudopregnant mice undergoing induced decidualization, as detected through in situ hybridization and immunofluorescence. CD82\/KAI1 expression showed a significant time-dependent increase in cultured stromal cells after 24 and 48 h of progesterone (P4) and estrogen (E2) treatment. This was accompanied by a notable upregulation of decidualization markers, including cyclin D3 and PR. After transducing stromal cells with the adenovirus-overexpressing CD82\/KAI1 for 48 h, the expression of cyclin D3 protein increased. Meanwhile, there was an attenuated expression of CD82\/KAI1 due to an adenovirus siRNA knockdown, whereas cyclin D3 and PR expressions were not affected. Our findings suggest a potential role of CD82\/KAI1 in regulating the process of decidualization, providing insights into stromal cell differentiation.<\/jats:p>","DOI":"10.3390\/cimb46030118","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T05:20:32Z","timestamp":1709011232000},"page":"1799-1809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Potential Role of CD82\/KAI1 during Uterine Decidualization in Mice"],"prefix":"10.3390","volume":"46","author":[{"given":"Qijun","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Engineering Research Center for Rodent Laboratory Animals, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1530\/REP-08-0539","article-title":"Cell cycle regulatory control for uterine stromal cell decidualization in implantation","volume":"137","author":"Das","year":"2009","journal-title":"Reproduction"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr. 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