{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:49:29Z","timestamp":1780400969888,"version":"3.54.1"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005375","name":"Latvian Council of Science","doi-asserted-by":"publisher","award":["lzp-2018\/2-0059"],"award-info":[{"award-number":["lzp-2018\/2-0059"]}],"id":[{"id":"10.13039\/501100005375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves\u2019 disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production. The aim of this study was to assess the associations of genetic factors with selenium levels in a cohort of adults with HT and GD and healthy controls from Latvia. A total of 148 GD patients, 102 HT patients and 2442 control participants were included in the study. The genotypes were determined using genome-wide genotyping; imputation was carried out using the TOPMed r2 imputation panel; and association analysis was performed with PLINK v1.90b7. We found three loci associated with GD (LSAMP, HNRNPA3P5, and NTN1) and one locus associated with HT (VAT1L); furthermore, one locus was associated with a serum selenium concentration &gt; 80 \u00b5g\/L (LINC01544\/RNF152\/PIGN). The detected associations could be attributed to population-specific effects or unknown stratification in our cohort, and further assessment of these results is required to explain the relationships of genetic traits with AITD and other phenotypes.<\/jats:p>","DOI":"10.3390\/cimb46030162","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T10:54:38Z","timestamp":1710759278000},"page":"2553-2565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort"],"prefix":"10.3390","volume":"46","author":[{"given":"Sabine","family":"Upmale-Engela","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Vaivode","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raitis","family":"Peculis","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, Ratsupites Str. 1-k1, LV-1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Litvina","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, Ratsupites Str. 1-k1, LV-1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Zake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-8724","authenticated-orcid":false,"given":"Andrejs","family":"Skesters","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-5985","authenticated-orcid":false,"given":"Deniss","family":"Gogins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Rovite","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, Ratsupites Str. 1-k1, LV-1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilze","family":"Konrade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Department of Endocrinology, Riga East Clinical Hospital, Hipokrata Str. 2, LV-1038 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"ref_1","unstructured":"Anaya, J.M., Shoenfeld, Y., Rojas-Villarraga, A., Levy, R.A., and Cervera, R. 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