{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:36:15Z","timestamp":1789140975021,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa para el Desarrollo Profesional Docente (PRODEP)","award":["511-6\/2019-3839"],"award-info":[{"award-number":["511-6\/2019-3839"]}]},{"name":"Patronato of the Universidad Aut\u00f3noma de Nayarit","award":["511-6\/2019-3839"],"award-info":[{"award-number":["511-6\/2019-3839"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>DNAM-1 (CD226) is an activating receptor expressed in CD8+ T cells, NK cells, and monocytes. It has been reported that two SNPs in the DNAM-1 gene, rs763361 C&gt;T and rs727088 G&gt;A, have been associated with different autoimmune diseases; however, the role of DNAM-1 in ankylosing spondylitis has been less studied. For this reason, we focused on the study of these two SNPs in association with ankylosing spondylitis. For this, 34 patients and 70 controls were analyzed using endpoint PCR with allele-specific primers. Our results suggest that rs763361 C&gt;T is involved as a possible protective factor under the CT co-dominant model (OR = 0.34, 95% CI = 0.13\u20130.88, p = 0.022) and the CT + TT dominant model (OR = 0.39, 95% CI = 0.17\u20130.90, p = 0.025), while rs727088 G&gt;A did not show an association with the disease in any of the inheritance models. When analyzing the relationships of the haplotypes, we found that the T + A haplotype (OR = 0.31, 95% CI = 0.13\u20130.73, p = 0.0083) is a protective factor for developing the disease. In conclusion, the CT and CT + TT variants of rs763361 C&gt;T and the T + A haplotype were considered as protective factors for developing ankylosing spondylitis.<\/jats:p>","DOI":"10.3390\/cimb46040176","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:14:12Z","timestamp":1711376052000},"page":"2819-2826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Variant of DNAM-1 rs763361 C&gt;T Is Associated with Ankylosing Spondylitis in a Mexican Population"],"prefix":"10.3390","volume":"46","author":[{"given":"Alejandro","family":"V\u00e1zquez-Reyes","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-9947","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"Zambrano-Zaragoza","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Agraz-Cibri\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Fabiola","family":"Ay\u00f3n-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-9010","authenticated-orcid":false,"given":"Gloria Yareli","family":"Guti\u00e9rrez-Silerio","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Nutrici\u00f3n, Departamento de Investigaci\u00f3n Biom\u00e9dica, Faculta de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76140, Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Del Toro-Arreola","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nico Degenerativas, Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Guillermo","family":"Alejandre-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nico Degenerativas, Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Ortiz-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Reumatolog\u00eda, Servicio de Medicina Interna, Instituto Mexicano del Seguro Social (IMSS), Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-1431","authenticated-orcid":false,"given":"Jesse","family":"Haramati","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda, Departamento de Biolog\u00eda Celular y Molecular, Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Celeste","family":"Tovar-Ocampo","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Victorio-De los Santos","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Guti\u00e9rrez-Franco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmico Biol\u00f3gicas y Farmac\u00e9uticas (UACQByF), Universidad Aut\u00f3noma de Nayarit, Tepic 63000, Nayarit, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrrheum.2010.79","article-title":"Pathogenesis of ankylosing spondylitis","volume":"6","author":"Tam","year":"2010","journal-title":"Nat. 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