{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:00:38Z","timestamp":1792789238124,"version":"4.5.0"},"reference-count":156,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01DK131930(NIDDK)"],"award-info":[{"award-number":["R01DK131930(NIDDK)"]}]},{"name":"NIH","award":["R56DK131531(NIDDK)"],"award-info":[{"award-number":["R56DK131531(NIDDK)"]}]},{"name":"NIH","award":["R21MH132483(NIMH)"],"award-info":[{"award-number":["R21MH132483(NIMH)"]}]},{"name":"NIH","award":["R33AI136100(NIAID)"],"award-info":[{"award-number":["R33AI136100(NIAID)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The emergence of combination antiretroviral therapy (cART) has greatly transformed the life expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV have access to this life-saving therapy. However, this progress has come with a new challenge: an increase in age-related non-AIDS conditions among patients with HIV. These conditions manifest earlier in PWH than in uninfected individuals, accelerating the aging process. Like PWH, the uninfected aging population experiences immunosenescence marked by an increased proinflammatory environment. This phenomenon is linked to chronic inflammation, driven in part by cellular structures called inflammasomes. Inflammatory signaling pathways activated by HIV-1 infection play a key role in inflammasome formation, suggesting a crucial link between HIV and a chronic inflammatory state. This review outlines the inflammatory processes triggered by HIV-1 infection and aging, with a focus on the inflammasomes. This review also explores current research regarding inflammasomes and potential strategies for targeting inflammasomes to mitigate inflammation. Further research on inflammasome signaling presents a unique opportunity to develop targeted interventions and innovative therapeutic modalities for combating HIV and aging-associated inflammatory processes.<\/jats:p>","DOI":"10.3390\/cimb46050287","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T11:26:17Z","timestamp":1715858777000},"page":"4768-4786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Perfect Storm: The Convergence of Aging, Human Immunodeficiency Virus Infection, and Inflammasome Dysregulation"],"prefix":"10.3390","volume":"46","author":[{"given":"Siva","family":"Thirugnanam","sequence":"first","affiliation":[{"name":"Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA"},{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Rout","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA"},{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Tulane Center for Aging, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2991\/jegh.k.210621.001","article-title":"Global Epidemiology of HIV\/AIDS: A Resurgence in North America and Europe","volume":"11","author":"Govender","year":"2021","journal-title":"J. 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