{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:08:07Z","timestamp":1789423687396,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Osteosarcoma malignancy currently represents a major health problem; therefore, the need for new therapy approaches is of great interest. In this regard, the current study aims to evaluate the anti-neoplastic potential of a newly developed phosphinic acid derivative (2-carboxyethylphenylphosphinic acid) and, subsequently, to outline its pharmaco-toxicological profile by employing two different in vitro human cell cultures (keratinocytes\u2014HaCaT\u2014and osteosarcoma SAOS-2 cells), employing different techniques (MTT assay, cell morphology assessment, LDH assay, Hoechst staining and RT-PCR). Additionally, the results obtained are compared with three commercially available phosphorus-containing compounds (P1, P2, P3). The results recorded for the newly developed compound (P4) revealed good biocompatibility (cell viability of 77%) when concentrations up to 5 mM were used on HaCaT cells for 24 h. Also, the HaCaT cultures showed no significant morphological alterations or gene modulation, thus achieving a biosafety profile even superior to some of the commercial products tested herein. Moreover, in terms of anti-osteosarcoma activity, 2-carboxyethylphenylphosphinic acid expressed promising activity on SAOS-2 monolayers, the cells showing viability of only 55%, as well as apoptosis features and important gene expression modulation, especially Bid downregulation. Therefore, the newly developed compound should be considered a promising candidate for further in vitro and in vivo research related to osteosarcoma therapy.<\/jats:p>","DOI":"10.3390\/cimb46050290","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T11:26:17Z","timestamp":1715858777000},"page":"4815-4831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Biological Impact of Some Phosphonic and Phosphinic Acid Derivatives on Human Osteosarcoma"],"prefix":"10.3390","volume":"46","author":[{"given":"Zakzak","family":"Khaled","sequence":"first","affiliation":[{"name":"Pharmaceutical Technology, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Formulation and Technology of Drugs Research Center, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2nd Eftimie 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Ion","family":"Varan","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, \u201cKing Mihai I\u201d University of Life Sciences from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Adriana","family":"Dehelean","sequence":"additional","affiliation":[{"name":"Research Center for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Department of Toxicology and Drug Industry, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Vlaia","sequence":"additional","affiliation":[{"name":"Pharmaceutical Technology, Faculty of Pharmacy, \u201cVictor Babe\u015f\u201d University of 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