{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:58:11Z","timestamp":1790899091522,"version":"4.1.0"},"reference-count":190,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Key Technologies R&amp;D Program","award":["GUIKE AB23026082"],"award-info":[{"award-number":["GUIKE AB23026082"]}]},{"name":"Guangxi Key Technologies R&amp;D Program","award":["GUIKE AD23026289"],"award-info":[{"award-number":["GUIKE AD23026289"]}]},{"name":"Specific Research Project of Guangxi for Research Base and Talents","award":["GUIKE AB23026082"],"award-info":[{"award-number":["GUIKE AB23026082"]}]},{"name":"Specific Research Project of Guangxi for Research Base and Talents","award":["GUIKE AD23026289"],"award-info":[{"award-number":["GUIKE AD23026289"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.<\/jats:p>","DOI":"10.3390\/cimb46060348","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:45:50Z","timestamp":1718181950000},"page":"5825-5844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-5484","authenticated-orcid":false,"given":"Yiduo","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China"},{"name":"College of Veterinary Medicine, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejia","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-1826","authenticated-orcid":false,"given":"Jiakang","family":"He","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmin","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","unstructured":"(2023). 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