{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:22:01Z","timestamp":1789017721666,"version":"build-2803163510"},"reference-count":124,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Diffuse large B cell lymphoma (DLBCL) is a multifaceted condition characterized by significant diversity in its molecular and pathological subtypes and clinical manifestation. Despite the progress made in the treatment of DLBCL through the development of novel drugs, an estimated one-third of patients encounter relapse or acquire refractory disease. The tumor microenvironment (TME) of DLBCL, a complex network consisting of cellular and noncellular components that engage in interactions with the tumor, is a parameter that is gaining increasing attention. The TME comprises both the immune and nonimmune microenvironments. The immune microenvironment comprises natural killer (NK) cells, dendritic cells (DCs), tumor-associated macrophages (TAMs), neutrophils, myeloid-derived suppressor cells (MDSCs), and T and B lymphocytes. The nonimmune microenvironment consists of the extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), mesenchymal stromal cells, and other molecules that are secreted. Despite ongoing research, the exact impact of these components and their interaction on the progression of the disease remains elusive. A comprehensive review of significant discoveries concerning the cellular and noncellular constituents, molecular characteristics, and treatment response and prognosis of the TME in DLBCL, as well as the potential targeting of the TME with novel therapeutic approaches, is provided in this article.<\/jats:p>","DOI":"10.3390\/cimb46070420","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"7048-7064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Unraveling the Immune Microenvironment in Diffuse Large B-Cell Lymphoma: Prognostic and Potential Therapeutic Implications"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-467X","authenticated-orcid":false,"given":"Epameinondas","family":"Koumpis","sequence":"first","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-6652","authenticated-orcid":false,"given":"Alexandra","family":"Papoudou-Bai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Papathanasiou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-487X","authenticated-orcid":false,"given":"Evangelos","family":"Kolettas","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 110 Ioannina, Greece"},{"name":"Biomedical Research Institute, Foundation for Research and Technology, 45 110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kanavaros","sequence":"additional","affiliation":[{"name":"Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-5646","authenticated-orcid":false,"given":"Eleftheria","family":"Hatzimichael","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45 500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1056\/NEJMra2027612","article-title":"Diffuse Large B-Cell Lymphoma","volume":"384","author":"Sehn","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma","volume":"386","author":"Tilly","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1182\/blood-2005-04-1399","article-title":"Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction","volume":"106","author":"Bea","year":"2005","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1200\/JCO.2010.30.0368","article-title":"Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab","volume":"29","author":"Meyer","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800130","article-title":"Diffuse large B-cell lymphomas with germinal center B-cell-like differentiation immunophenotypic profile are associated with high apoptotic index, high expression of the proapoptotic proteins bax, bak and bid and low expression of the antiapoptotic protein bcl-xl","volume":"17","author":"Bai","year":"2004","journal-title":"Mod. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.MP.0000067684.78221.6E","article-title":"Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas","volume":"16","author":"Bai","year":"2003","journal-title":"Mod. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10428194.2015.1034704","article-title":"The expression levels of JunB, JunD and p-c-Jun are positively correlated with tumor cell proliferation in diffuse large B-cell lymphomas","volume":"57","author":"Goussia","year":"2016","journal-title":"Leuk. Lymphoma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-021-01134-x","article-title":"Targeting the tumor microenvironment in B-cell lymphoma: Challenges and opportunities","volume":"14","author":"Liu","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1016\/j.semcancer.2015.02.007","article-title":"Cancer prevention and therapy through the modulation of the tumor microenvironment","volume":"35","author":"Casey","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/2159-8290.CD-20-1808","article-title":"Therapeutic Targeting of the Tumor Microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1158\/2159-8290.CD-20-0839","article-title":"Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures","volume":"11","author":"Kotlov","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1182\/blood.2023021002","article-title":"Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma","volume":"143","author":"Cerchietti","year":"2024","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yu, T., Xu-Monette, Z.Y., Lagoo, A., Shuai, W., Wang, B., Neff, J., Carrillo, L.F., Carlsen, E.D., Pina-Oviedo, S., and Young, K.H. (2024). Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1335689"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/ajh.27075","article-title":"2024 Update: Advances in the risk stratification and management of large B-cell lymphoma","volume":"98","author":"Tavakkoli","year":"2023","journal-title":"Am. J. Hematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hon.2842","article-title":"Real-life experience with the combination of polatuzumab vedotin, rituximab, and bendamustine in aggressive B-cell lymphomas","volume":"39","author":"Dimou","year":"2021","journal-title":"Hematol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s13046-022-02579-9","article-title":"Insights into the tumor microenvironment of B cell lymphoma","volume":"41","author":"Ng","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/imr.12860","article-title":"T follicular helper cells in germinal center B cell selection and lymphomagenesis","volume":"296","author":"Mintz","year":"2020","journal-title":"Immunol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.intimp.2018.05.025","article-title":"The prevalence and function of CD4+CXCR5+Foxp3+ follicular regulatory T cells in diffuse large B cell lymphoma","volume":"61","author":"Cha","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/10245332.2017.1300623","article-title":"The role of follicular T helper cells in patients with malignant lymphoid disease","volume":"22","author":"Zhou","year":"2017","journal-title":"Hematology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.it.2012.11.002","article-title":"Differentiation and function of Foxp3+ effector regulatory T cells","volume":"34","author":"Cretney","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Georgoulis, V., Papoudou-Bai, A., Makis, A., Kanavaros, P., and Hatzimichael, E. (2023). Unraveling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications. Biology, 12.","DOI":"10.20944\/preprints202305.1213.v1"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI19441","article-title":"Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25\u2212 T cells","volume":"112","author":"Walker","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/intimm\/dxh165","article-title":"Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells","volume":"16","author":"Yagi","year":"2004","journal-title":"Int. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clim.2006.10.014","article-title":"Transient regulatory T-cells: A state attained by all activated human T-cells","volume":"123","author":"Pillai","year":"2007","journal-title":"Clin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAI.0000000000000335","article-title":"Intratumoral FOXP3+ Regulatory T Cells in Diffuse Large B-Cell Lymphoma","volume":"25","author":"Abdou","year":"2017","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/10428190701824536","article-title":"Prognostic impact of tumor infiltrating FOXP3 positive regulatory T cells in diffuse large B-cell lymphoma at diagnosis","volume":"49","author":"Lee","year":"2008","journal-title":"Leuk. Lymphoma"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e060659","DOI":"10.1136\/bmjopen-2021-060659","article-title":"Prognostic value of FOXP3+ regulatory T cells in patients with diffuse large B-cell lymphoma: A systematic review and meta-analysis","volume":"12","author":"Bai","year":"2022","journal-title":"BMJ Open"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107662","DOI":"10.1016\/j.intimp.2021.107662","article-title":"High levels of Tim-3+Foxp3+Treg cells in the tumor microenvironment is a prognostic indicator of poor survival of diffuse large B cell lymphoma patients","volume":"96","author":"Zhong","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12967-024-05002-3","article-title":"Diffuse large B-cell lymphoma: The significance of CD8+ tumor-infiltrating lymphocytes exhaustion mediated by TIM3\/Galectin-9 pathway","volume":"22","author":"Zhu","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41590-021-00949-7","article-title":"Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity","volume":"22","author":"Collier","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00277-018-3534-z","article-title":"Novel risk stratification of de novo diffuse large B cell lymphoma based on tumour-infiltrating T lymphocytes evaluated by flow cytometry","volume":"98","author":"Chen","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41379-018-0193-5","article-title":"PD-1\/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: A study from the International DLBCL Consortium Program","volume":"32","author":"Li","year":"2019","journal-title":"Mod. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1200\/JCO.18.00766","article-title":"Nivolumab for Relapsed\/Refractory Diffuse Large B-Cell Lymphoma in Patients Ineligible for or Having Failed Autologous Transplantation: A Single-Arm, Phase II Study","volume":"37","author":"Ansell","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ma, J., Pang, X., Li, J., Zhang, W., and Cui, W. (2022). The immune checkpoint expression in the tumor immune microenvironment of DLBCL: Clinicopathologic features and prognosis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1069378"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cell.2018.11.010","article-title":"Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3","volume":"176","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ma, J., Yan, S., Zhao, Y., Yan, H., Zhang, Q., and Li, X. (2023). Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1265255"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","article-title":"TIM3 comes of age as an inhibitory receptor","volume":"20","author":"Wolf","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1182\/bloodadvances.2020003080","article-title":"Functional characterization of PD1+TIM3+ tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade","volume":"5","author":"Roussel","year":"2021","journal-title":"Blood Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1158\/1078-0432.CCR-23-1554","article-title":"Tumor-Infiltrating Normal B Cells Revealed by Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic and Crucial for Antitumor Immune Responses in DLBCL","volume":"29","author":"Li","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/cncr.34519","article-title":"Immune scoring model based on immune cell infiltration to predict prognosis in diffuse large B-cell lymphoma","volume":"129","author":"Yang","year":"2023","journal-title":"Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.4049\/jimmunol.175.3.1636","article-title":"TLR7\/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production","volume":"175","author":"Hart","year":"2005","journal-title":"J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nri1055","article-title":"Immune functions encoded by the natural killer gene complex","volume":"3","author":"Yokoyama","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival","volume":"5","author":"Parham","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12943-020-01238-x","article-title":"Natural killer cells in cancer biology and therapy","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nri.2015.9","article-title":"Natural killer cell memory in infection, inflammation and cancer","volume":"16","author":"Cerwenka","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1182\/blood-2017-07-796342","article-title":"Immune evasion via PD-1\/PD-L1 on NK cells and monocyte\/macrophages is more prominent in Hodgkin lymphoma than DLBCL","volume":"131","author":"Vari","year":"2018","journal-title":"Blood"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, Z., Jiang, R., Li, Q., Wang, H., Tao, Q., and Zhai, Z. (2021). Elevated M-MDSCs in Circulation Are Indicative of Poor Prognosis in Diffuse Large B-Cell Lymphoma Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081768"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/ijc.30232","article-title":"Myeloid-derived suppressor cells as effectors of immune suppression in cancer","volume":"139","author":"Pyzer","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e995541","DOI":"10.1080\/2162402X.2014.995541","article-title":"Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma","volume":"4","author":"Sato","year":"2015","journal-title":"Oncoimmunology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nri3175","article-title":"Coordinated regulation of myeloid cells by tumours","volume":"12","author":"Gabrilovich","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2010-05-283820","article-title":"Immunosuppressive CD14+HLA-DR(low)\/\u2212 monocytes in B-cell non-Hodgkin lymphoma","volume":"117","author":"Lin","year":"2011","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/156652409787314499","article-title":"Monocyte dependent regulation of autoimmune inflammation","volume":"9","author":"Nicholson","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.intimp.2011.01.026","article-title":"MDSC in autoimmunity","volume":"11","author":"Cripps","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy","volume":"20","author":"Jaillon","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41423-024-01147-9","article-title":"Neutrophils in the tumor microenvironment\u2014When a company becomes a crowd","volume":"21","author":"Fridlender","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eadf6493","DOI":"10.1126\/science.adf6493","article-title":"Deterministic reprogramming of neutrophils within tumors","volume":"383","author":"Ng","year":"2024","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"104576","DOI":"10.1016\/j.cellimm.2022.104576","article-title":"Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells","volume":"379","author":"Zheng","year":"2022","journal-title":"Cell. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1182\/blood-2006-02-001800","article-title":"Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness","volume":"109","author":"Schwaller","year":"2007","journal-title":"Blood"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1158\/0008-5472.CAN-16-0786","article-title":"CXCL-8\/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL","volume":"77","author":"Manfroi","year":"2017","journal-title":"Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"154661","DOI":"10.1016\/j.prp.2023.154661","article-title":"Different patterns of mast cell distribution in B-cell non-Hodgkin lymphomas","volume":"248","author":"Guidolin","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2141.2007.06612.x","article-title":"Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma","volume":"138","author":"Berglund","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.leukres.2014.09.007","article-title":"Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma","volume":"38","author":"Marinaccio","year":"2014","journal-title":"Leuk. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Patente, T.A., Pinho, M.P., Oliveira, A.A., Evangelista, G.C.M., Bergami-Santos, P.C., and Barbuto, J.A.M. (2018). Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03176"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/cjp2.283","article-title":"Decreased CD11c-positive dendritic cells in the tumor microenvironment predict double-hit\/triple-hit genotype and survival in diffuse large B-cell lymphoma","volume":"8","author":"Yuan","year":"2022","journal-title":"J. Pathol. Clin. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/annonc\/mdy450","article-title":"Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue","volume":"29","author":"Ciavarella","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Elhelbawy, N.G., Nassar, A.A.H., Eltorgoman, A.E.A., Saber, S.M., and Badr, E.A. (2020). Immunological microenvironment gene expression in patients with diffuse large B cell non Hodgkin lymphoma. Biochem. Biophys. Rep., 21.","DOI":"10.1016\/j.bbrep.2020.100731"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.2174\/0929867328666210720143721","article-title":"The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis\u2014Current Status","volume":"28","author":"Dallavalasa","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13045-019-0760-3","article-title":"Tumor-associated macrophages in tumor metastasis: Biological roles and clinical therapeutic applications","volume":"12","author":"Lin","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00281-023-00988-2","article-title":"The role of macrophages in the tumor microenvironment and tumor metabolism","volume":"45","author":"Sadhukhan","year":"2023","journal-title":"Semin. Immunopathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8586354","DOI":"10.1155\/2019\/8586354","article-title":"Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis","volume":"2019","author":"Cioroianu","year":"2019","journal-title":"Anal. Cell. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/ijlh.12203","article-title":"CD14+ HLA-DR low\/\u2212 monocytes as indicator of disease aggressiveness in B-cell non-Hodgkin lymphoma","volume":"36","author":"Khalifa","year":"2014","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/hon.2142","article-title":"High density of CD68+\/CD163+ tumour-associated macrophages (M2-TAM) at diagnosis is significantly correlated to unfavorable prognostic factors and to poor clinical outcomes in patients with diffuse large B-cell lymphoma","volume":"33","author":"Marchesi","year":"2015","journal-title":"Hematol. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3109\/10428194.2013.879713","article-title":"An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone","volume":"55","author":"Nam","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2559.2011.04096.x","article-title":"Tumour-associated macrophages in diffuse large B-cell lymphoma: A study of the Osaka Lymphoma Study Group","volume":"60","author":"Wada","year":"2012","journal-title":"Histopathology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1440-1827.2008.02268.x","article-title":"Expression of CD68+ tumor-associated macrophages in patients with diffuse large B-cell lymphoma and its relation to prognosis","volume":"58","author":"Hasselblom","year":"2008","journal-title":"Pathol. Int."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1309\/AJCPJX4BJV9NLQHY","article-title":"The stromal cell marker SPARC predicts for survival in patients with diffuse large B-cell lymphoma treated with rituximab","volume":"135","author":"Meyer","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s12032-011-0123-6","article-title":"High expression of tumor-infiltrating macrophages correlates with poor prognosis in patients with diffuse large B-cell lymphoma","volume":"29","author":"Cai","year":"2012","journal-title":"Med. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3324\/haematol.2014.113472","article-title":"Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: A correlative study from a Nordic phase II trial","volume":"100","author":"Fiskvik","year":"2015","journal-title":"Haematologica"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2217\/bmm-2022-0764","article-title":"Pretreatment soluble Siglec-5 protein predicts early progression and R-CHOP efficacy in diffuse large B-cell lymphoma","volume":"17","author":"Sun","year":"2023","journal-title":"Biomark. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1182\/bloodadvances.2023010052","article-title":"Soluble CD163 predicts outcome in both chemoimmunotherapy and targeted therapy-treated mantle cell lymphoma","volume":"7","author":"Nikkarinen","year":"2023","journal-title":"Blood Adv."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Koudouna, A., Gkioka, A.I., Gkiokas, A., Tryfou, T.M., Papadatou, M., Alexandropoulos, A., Bartzi, V., Kafasi, N., and Kyrtsonis, M.C. (2024). Serum-Soluble CD163 Levels as a Prognostic Biomarker in Patients with Diffuse Large B-Cell Lymphoma Treated with Chemoimmunotherapy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052862"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2010.07.044","article-title":"Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma","volume":"142","author":"Chao","year":"2010","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13045-020-00930-1","article-title":"Role of CD47 in Hematological Malignancies","volume":"13","author":"Eladl","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1111\/cas.14437","article-title":"Combination of CD47 and signal-regulatory protein-\u03b1 constituting the \u201cdon\u2019t eat me signal\u201d is a prognostic factor in diffuse large B-cell lymphoma","volume":"111","author":"Kazama","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1182\/blood-2022-167772","article-title":"Magrolimab in Combination with Rituximab + Chemotherapy in Patients with Relapsed or Refractory (R\/R) Diffuse Large B-Cell Lymphoma (DLBCL)","volume":"140","author":"Maakaron","year":"2022","journal-title":"Blood"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","article-title":"Cancer-associated fibroblasts: From basic science to anticancer therapy","volume":"55","author":"Yang","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"Biffi","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Haro, M., and Orsulic, S. (2018). A Paradoxical Correlation of Cancer-Associated Fibroblasts With Survival Outcomes in B-Cell Lymphomas and Carcinomas. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00098"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1523-1747.ep12363389","article-title":"Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor","volume":"107","author":"Frazier","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e28989","DOI":"10.4161\/onci.28989","article-title":"Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies","volume":"3","author":"Sangaletti","year":"2014","journal-title":"Oncoimmunology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2009.11.018","article-title":"Modulation of matrix remodeling by SPARC in neoplastic progression","volume":"21","author":"Chlenski","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2162-3619-2-27","article-title":"The combined expression of the stromal markers fibronectin and SPARC improves the prediction of survival in diffuse large B-cell lymphoma","volume":"2","author":"Brandt","year":"2013","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Takahara, T., Nakamura, S., Tsuzuki, T., and Satou, A. (2023). The Immunology of DLBCL. Cancers, 15.","DOI":"10.3390\/cancers15030835"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8+ T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e2104504118","DOI":"10.1073\/pnas.2104504118","article-title":"Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma","volume":"118","author":"Fangazio","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ccr.2011.11.006","article-title":"Combined genetic inactivation of \u03b22-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma","volume":"20","author":"Lieu","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1158\/1078-0432.CCR-18-3200","article-title":"Biological Consequences of MHC-II Expression by Tumor Cells in Cancer","volume":"25","author":"Axelrod","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1182\/blood-2011-07-363820","article-title":"Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma","volume":"119","author":"Wilkinson","year":"2012","journal-title":"Blood"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/gcc.22072","article-title":"The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma","volume":"52","author":"Bertrand","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1189\/jlb.0610351","article-title":"Role of CD27\/CD70 pathway of activation in immunity and tolerance","volume":"89","author":"Denoeud","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Honikel, M.M., and Olejniczak, S.H. (2022). Co-Stimulatory Receptor Signaling in CAR-T Cells. Biomolecules, 12.","DOI":"10.3390\/biom12091303"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Modi, D., Potugari, B., and Uberti, J. (2021). Immunotherapy for Diffuse Large B-Cell Lymphoma: Current Landscape and Future Directions. Cancers, 13.","DOI":"10.3390\/cancers13225827"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/2159-8290.CD-18-1090","article-title":"Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition","volume":"9","author":"Ennishi","year":"2019","journal-title":"Cancer Discov."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/cas.14822","article-title":"Phase 1 study of tazemetostat in Japanese patients with relapsed or refractory B-cell lymphoma","volume":"112","author":"Munakata","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.clml.2021.12.014","article-title":"Combination of Atezolizumab and Tazemetostat in Patients with Relapsed\/Refractory Diffuse Large B-Cell Lymphoma: Results From a Phase Ib Study","volume":"22","author":"Palomba","year":"2022","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/CMAR.S400013","article-title":"Drug-Resistance Mechanism and New Targeted Drugs and Treatments of Relapse and Refractory DLBCL","volume":"15","author":"Zhang","year":"2023","journal-title":"Cancer Manag. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s13238-020-00694-x","article-title":"HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma","volume":"11","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood-2016-02-699520","article-title":"Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma","volume":"128","author":"Assouline","year":"2016","journal-title":"Blood"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/07357907.2021.1983584","article-title":"Phase II Study of Single-Agent and Combination Everolimus and Panobinostat in Relapsed or Refractory Diffuse Large B-Cell Lymphoma","volume":"39","author":"Islam","year":"2021","journal-title":"Cancer Investig."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3324\/haematol.2023.283002","article-title":"Results from a phase I trial of pembrolizumab plus vorinostat in relapsed\/refractory B-cell non-Hodgkin lymphoma","volume":"109","author":"Godfrey","year":"2024","journal-title":"Haematologica"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Opinto, G., Vegliante, M.C., Negri, A., Skrypets, T., Loseto, G., Pileri, S.A., Guarini, A., and Ciavarella, S. (2020). The Tumor Microenvironment of DLBCL in the Computational Era. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00351"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nri2572","article-title":"Cracking the BAFF code","volume":"9","author":"Mackay","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1038\/onc.2014.403","article-title":"The tumor microenvironment shapes hallmarks of mature B-cell malignancies","volume":"34","author":"Shain","year":"2015","journal-title":"Oncogene"}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/7\/420\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:10:27Z","timestamp":1760109027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/7\/420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":124,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["cimb46070420"],"URL":"https:\/\/doi.org\/10.3390\/cimb46070420","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}