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Taiwan","award":["CMRPF1M0171~2"],"award-info":[{"award-number":["CMRPF1M0171~2"]}]},{"name":"National Science and Technology Council, Taiwan","award":["CMRPF1N0011"],"award-info":[{"award-number":["CMRPF1N0011"]}]},{"name":"National Science and Technology Council, Taiwan","award":["ZRRPF3M0091"],"award-info":[{"award-number":["ZRRPF3M0091"]}]},{"name":"National Science and Technology Council, Taiwan","award":["ZRRPF3N0101"],"award-info":[{"award-number":["ZRRPF3N0101"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC 113-2635-B-255-001"],"award-info":[{"award-number":["NSTC 113-2635-B-255-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Gastric inflammation-related disorders are commonly observed digestive system illnesses characterized by the activation of proinflammatory cytokines, particularly tumor necrosis factor-\u03b1 (TNF-\u03b1). This results in the induction of cyclooxygenase-2 (COX-2)\/prostaglandin E2 (PEG2) and matrix metallopeptidase-9 (MMP-9). These factors contribute to the pathogenesis of gastric inflammation disorders. We examined the preventive effects of Lonicera japonica Thunb. ethanol extract (Lj-EtOH) on gastric inflammation induced by TNF-\u03b1 in normal human gastric mucosa epithelial cells (GES-1). The GES-1 cell line was used to establish a model that simulated the overexpression of COX-2\/PGE2 and MMP-9 proteins induced by TNF-\u03b1 to examine the anti-inflammatory properties of Lj extracts. The results indicated that Lj-EtOH exhibits significant inhibitory effects on COX-2\/PEG2 and MMP-9 activity, attenuates cell migration, and provides protection against TNF-\u03b1-induced gastric inflammation. The protective effects of Lj-EtOH are associated with the modulation of COX-2\/PEG2 and MMP-9 through the activation of TNFR\u2013ERK 1\/2 signaling pathways as well as the involvement of c-Fos and nuclear factor kappa B (NF-\u03baB) signaling pathways. Based on our findings, Lj-EtOH exhibits a preventive effect on human gastric epithelial cells. Consequently, it may represent a novel treatment for the management of gastric inflammation.<\/jats:p>","DOI":"10.3390\/cimb46070433","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:14:41Z","timestamp":1720610081000},"page":"7303-7323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-\u03b1-Induced Inflammatory Cyclooxygenase 2\/Prostaglandin E2 and Matrix Metalloproteinase 9"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-2472","authenticated-orcid":false,"given":"Hsi-Lung","family":"Hsieh","sequence":"first","affiliation":[{"name":"Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan"},{"name":"Department of Neurology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"},{"name":"Department of Chemical Engineering, R&D Center of Biochemical Engineering Technology, Ming Chi University of Technology, New Taipei City 301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, New Taipei Municipal TuCheng Hospital, New Taipei 236, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-8254","authenticated-orcid":false,"given":"Yu-Chia","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-2713","authenticated-orcid":false,"given":"Yi-Hsuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsiung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan"},{"name":"Department of Laboratory Medicine, Section of Clinical Serology and Immunology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-6616","authenticated-orcid":false,"given":"Ming-Ming","family":"Tsai","sequence":"additional","affiliation":[{"name":"Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan"},{"name":"Department of General Surgery, New Taipei Municipal TuCheng Hospital, New Taipei 236, Taiwan"},{"name":"Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"},{"name":"Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2011.08.016","article-title":"Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"138","author":"Shang","year":"2011","journal-title":"J. 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