{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:48:01Z","timestamp":1792453681342,"version":"4.5.0"},"reference-count":358,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004489","name":"MITACS","doi-asserted-by":"publisher","award":["33301"],"award-info":[{"award-number":["33301"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The \u03b2-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise \u03b2-cell function, contributing to the development of Type 2 Diabetes (T2D). A critical aspect of this dysfunction involves \u03b2-cell dedifferentiation and transdifferentiation, wherein these cells lose their specialized characteristics and adopt different identities, notably transitioning towards progenitor or other pancreatic cell types like \u03b1-cells. This process significantly contributes to \u03b2-cell malfunction and the progression of T2D, often surpassing the impact of outright \u03b2-cell loss. Alterations in the expressions of specific genes and transcription factors unique to \u03b2-cells, along with epigenetic modifications and environmental factors such as inflammation, oxidative stress, and mitochondrial dysfunction, underpin the occurrence of \u03b2-cell dedifferentiation and the onset of T2D. Recent research underscores the potential therapeutic value for targeting \u03b2-cell dedifferentiation to manage T2D effectively. In this review, we aim to dissect the intricate mechanisms governing \u03b2-cell dedifferentiation and explore the therapeutic avenues stemming from these insights.<\/jats:p>","DOI":"10.3390\/cimb46070453","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T16:55:36Z","timestamp":1721321736000},"page":"7621-7667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Targeting \u03b2-Cell Plasticity: A Promising Approach for Diabetes Treatment"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3168-0379","authenticated-orcid":false,"given":"Esmaeel","family":"Ghasemi Gojani","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Norouzkhani","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Shujat","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-1938","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-6928","authenticated-orcid":false,"given":"Igor","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0516","article-title":"Mechanisms of \u03b2-cell dedifferentiation in diabetes: Recent findings and future research directions","volume":"236","author":"Bensellam","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s12276-023-01043-8","article-title":"Reversing pancreatic \u03b2-cell dedifferentiation in the treatment of type 2 diabetes","volume":"55","author":"Son","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.tem.2022.08.003","article-title":"Cannabinoids and terpenes for diabetes mellitus and its complications: From mechanisms to new therapies","volume":"33","author":"Kovalchuk","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/dom.15300","article-title":"Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?","volume":"26","author":"Tanday","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Honzawa, N., and Fujimoto, K. (2021). The Plasticity of Pancreatic \u03b2-Cells. Metabolites, 11.","DOI":"10.3390\/metabo11040218"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Khin, P.-P., Lee, J.-H., and Jun, H.-S. (2021). A Brief Review of the Mechanisms of \u03b2-Cell Dedifferentiation in Type 2 Diabetes. Nutrients, 13.","DOI":"10.3390\/nu13051593"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1210\/jc.2015-2860","article-title":"Evidence of \u03b2-Cell Dedifferentiation in Human Type 2 Diabetes","volume":"101","author":"Cinti","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2013.12.002","article-title":"Pdx1 Maintains \u03b2 Cell Identity and Function by Repressing an \u03b1 Cell Program","volume":"19","author":"Gao","year":"2014","journal-title":"Cell Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to \u03b2-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Eizirik, D.L., Sammeth, M., Bouckenooghe, T., Bottu, G., Sisino, G., Igoillo-Esteve, M., Ortis, F., Santin, I., Colli, M.L., and Barthson, J. (2012). The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002552"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/stem.3059","article-title":"Beta-cell dedifferentiation in type 2 diabetes: Concise review","volume":"37","author":"Efrat","year":"2019","journal-title":"Stem Cells"},{"key":"ref_12","first-page":"13","article-title":"In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A","volume":"1","author":"Chikodili","year":"2022","journal-title":"Sci. Phytochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41574-023-00817-4","article-title":"Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases","volume":"19","author":"Andersen","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.isci.2019.05.030","article-title":"Antagonistic Glucagon Receptor Antibody Promotes \u03b1-Cell Proliferation and Increases \u03b2-Cell Mass in Diabetic Mice","volume":"16","author":"Wei","year":"2019","journal-title":"iScience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2337\/db22-0784","article-title":"Glucagon Acting at the GLP-1 Receptor Contributes to \u03b2-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice","volume":"72","author":"Wei","year":"2023","journal-title":"Diabetes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110872","DOI":"10.1016\/j.celrep.2022.110872","article-title":"Glucagon-receptor-antagonism-mediated \u03b2-cell regeneration as an effective anti-diabetic therapy","volume":"39","author":"Xi","year":"2022","journal-title":"Cell Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/19382014.2020.1791530","article-title":"Targeting polyamine biosynthesis to stimulate beta cell regeneration in zebrafish","volume":"12","author":"Robertson","year":"2020","journal-title":"Islets"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2337\/db18-0856","article-title":"\u03b2-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity","volume":"68","author":"Mezza","year":"2019","journal-title":"Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-018-0088-0","article-title":"Pancreas regeneration","volume":"557","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","article-title":"Type 1 diabetes","volume":"391","author":"DiMeglio","year":"2018","journal-title":"Lancet"},{"key":"ref_21","first-page":"1","article-title":"Type 2 diabetes mellitus","volume":"1","author":"DeFronzo","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.2337\/dbi20-0001","article-title":"Subtypes of Type 2 Diabetes Determined From Clinical Parameters","volume":"69","author":"Ahlqvist","year":"2020","journal-title":"Diabetes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Liang, R., Liu, N., Wang, G., Sun, P., Liu, Y., Zou, J., Wang, L., Ding, X., Zhang, B., and Shen, Z. (2021). Cytohistologic analyses of \u03b2 cell dedifferentiation induced by inflammation in human islets. Eur. J. Inflamm., 19.","DOI":"10.1177\/20587392211014416"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1038\/s41598-017-06731-w","article-title":"The Role of Inflammation in \u03b2-cell Dedifferentiation","volume":"7","author":"Nordmann","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41419-023-05906-w","article-title":"Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding","volume":"14","author":"Urizar","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wang, H.-L., Wang, L., Zhao, C.-Y., and Lan, H.-Y. (2022). Role of TGF-Beta Signaling in Beta Cell Proliferation and Function in Diabetes. Biomolecules, 12.","DOI":"10.3390\/biom12030373"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e02809","DOI":"10.7554\/eLife.02809","article-title":"Reversal of \u03b2 cell de-differentiation by a small molecule inhibitor of the TGF\u03b2 pathway","volume":"3","author":"Blum","year":"2014","journal-title":"eLife"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41374-021-00684-5","article-title":"Role of angiogenesis in beta-cell epithelial\u2013mesenchymal transition in chronic pancreatitis-induced diabetes","volume":"102","author":"Qian","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1210\/en.2015-1793","article-title":"Activin enhances \u03b1-to \u03b2-cell transdifferentiation as a source for \u03b2-cells in male FSTL3 knockout mice","volume":"157","author":"Brown","year":"2016","journal-title":"Endocrinology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/jcmm.17110","article-title":"SDF-1 inhibits the dedifferentiation of islet \u03b2 cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4","volume":"26","author":"Chen","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101347","DOI":"10.1016\/j.molmet.2021.101347","article-title":"Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances \u03b2-cell proliferation and identity and relieves oxidative damage","volume":"54","author":"Bosma","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1210\/jc.2016-1350","article-title":"Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes","volume":"101","author":"Moin","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2337\/db16-1025","article-title":"Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes","volume":"66","author":"Michels","year":"2016","journal-title":"Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmet.2018.02.002","article-title":"Modeling human pancreatic beta cell dedifferentiation","volume":"10","author":"Diedisheim","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_36","first-page":"e97732","article-title":"Virus-like infection induces human \u03b2 cell dedifferentiation","volume":"3","author":"Oshima","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic \u03b1-cells to \u03b2-cells after extreme \u03b2-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/j.celrep.2018.02.032","article-title":"\u03b1 Cell Function and Gene Expression Are Compromised in Type 1 Diabetes","volume":"22","author":"Brissova","year":"2018","journal-title":"Cell Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"111719","DOI":"10.1016\/j.celrep.2022.111719","article-title":"Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia","volume":"41","author":"Hija","year":"2022","journal-title":"Cell Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hahn, M., van Krieken, P.P., Nord, C., Alanentalo, T., Morini, F., Xiong, Y., Eriksson, M., Mayer, J., Kostromina, E., and Ruas, J.L. (2020). Topologically selective islet vulnerability and self-sustained downregulation of markers for \u03b2-cell maturity in streptozotocin-induced diabetes. Commun. Biol., 3.","DOI":"10.1038\/s42003-020-01243-2"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1038\/s41467-022-32162-x","article-title":"Maladaptive positive feedback production of ChREBP\u03b2 underlies glucotoxic \u03b2-cell failure","volume":"13","author":"Katz","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00125-019-05046-x","article-title":"Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity","volume":"63","author":"Oshima","year":"2019","journal-title":"Diabetologia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101659","DOI":"10.1016\/j.molmet.2022.101659","article-title":"Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of \u03b2-cell identity and \u03b1-cell expansion in the mature pancreas","volume":"67","author":"Dobosz","year":"2023","journal-title":"Mol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Leenders, F., Groen, N., de Graaf, N., Engelse, M.A., Rabelink, T.J., de Koning, E.J.P., and Carlotti, F. (2021). Oxidative Stress Leads to \u03b2-Cell Dysfunction Through Loss of \u03b2-Cell Identity. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.690379"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2337\/db23-0212","article-title":"Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward \u03b2-Cell Failure","volume":"73","author":"Motomura","year":"2023","journal-title":"Diabetes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"21496","DOI":"10.1038\/s41598-022-25405-w","article-title":"Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation","volume":"12","author":"Dadheech","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.7150\/thno.90946","article-title":"NPC1 is required for postnatal islet \u03b2 cell differentiation by maintaining mitochondria turnover","volume":"14","author":"Liu","year":"2024","journal-title":"Theranostics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1038\/s41467-023-39978-1","article-title":"Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction","volume":"14","author":"Yeh","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1210\/clinem\/dgac535","article-title":"Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans","volume":"107","author":"Song","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E554","DOI":"10.1152\/ajpendo.00502.2015","article-title":"\u03b2-Cell dedifferentiation, reduced duct cell plasticity, and impaired \u03b2-cell mass regeneration in middle-aged rats","volume":"311","author":"Vilaseca","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101414","DOI":"10.1016\/j.molmet.2021.101414","article-title":"Increased glycolysis affects \u03b2-cell function and identity in aging and diabetes","volume":"55","author":"Murao","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e230174","DOI":"10.1530\/JOE-23-0174","article-title":"Sex-based impact of pancreatic islet stressors in GluCreERT2\/Rosa26-eYFP mice","volume":"259","author":"Tanday","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"310","DOI":"10.21037\/atm.2020.02.129","article-title":"Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance","volume":"8","author":"Yang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"109059","DOI":"10.1016\/j.cbi.2020.109059","article-title":"Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis","volume":"322","author":"Rasineni","year":"2020","journal-title":"Chem. Interactions"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.2337\/db07-0460","article-title":"Metabolic mechanisms of failure of intraportally transplanted pancreatic \u03b2-cells in rats: Role of lipotoxicity and prevention by leptin","volume":"56","author":"Lee","year":"2007","journal-title":"Diabetes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm.2277","article-title":"Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin","volume":"17","author":"Holland","year":"2011","journal-title":"Nat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.tp.0000189712.74495.82","article-title":"Streptozotocin-Induced Diabetes in Large Animals (Pigs\/Primates): Role of GLUT2 Transporter and \u03b2-cell Plasticity","volume":"81","author":"Dufrane","year":"2006","journal-title":"Transplantation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.molmet.2020.100982","article-title":"Characterizing pancreatic \u03b2-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis","volume":"37","author":"Feng","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1038\/srep11703","article-title":"Beta-cell regeneration from vimentin+\/MafB+ cells after STZ-induced extreme beta-cell ablation","volume":"5","author":"Cheng","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1530\/JOE-14-0373","article-title":"Glucocorticoid treatment and endocrine pancreas function: Implications for glucose homeostasis, insulin resistance and diabetes","volume":"223","author":"Rafacho","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.molmet.2019.12.012","article-title":"Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA","volume":"32","author":"Esguerra","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Beaupere, C., Liboz, A., F\u00e8ve, B., Blondeau, B., and Guillemain, G. (2021). Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020623"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00125-010-1898-2","article-title":"Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice","volume":"54","author":"Valtat","year":"2010","journal-title":"Diabetologia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"E488","DOI":"10.1152\/ajpendo.00068.2023","article-title":"Endocrine disruptors in plastics alter \u03b2-cell physiology and increase the risk of diabetes mellitus","volume":"324","author":"Fuentes","year":"2023","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Dos Santos, R.S., Medina-Gali, R.M., Babiloni-Chust, I., Marroqui, L., and Nadal, A. (2022). In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic \u03b2-Cell Model. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095040"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1038\/s41467-022-29945-7","article-title":"Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis","volume":"13","author":"Sidarala","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"102343","DOI":"10.1016\/j.ceca.2020.102343","article-title":"Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role","volume":"94","author":"Barazzuol","year":"2021","journal-title":"Cell Calcium"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"111681","DOI":"10.1016\/j.fct.2020.111681","article-title":"Bisphenol-A exposure during pregnancy alters pancreatic \u03b2-cell division and mass in male mice offspring: A role for ER\u03b2","volume":"145","author":"Ferrero","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"113266","DOI":"10.1016\/j.fct.2022.113266","article-title":"The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells","volume":"167","author":"Azevedo","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/en.2016-1390","article-title":"Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic \u03b2-Cell Growth During Early Life in Male Mice Offspring","volume":"157","author":"Servitja","year":"2016","journal-title":"Endocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"097022","DOI":"10.1289\/EHP1674","article-title":"Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring","volume":"125","author":"Bansal","year":"2017","journal-title":"Environ. Heal. Perspect."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"114396","DOI":"10.1016\/j.ecoenv.2022.114396","article-title":"Dibutyl phthalate affects insulin synthesis and secretion by regulating the mitochondrial apoptotic pathway and oxidative stress in rat insulinoma cells","volume":"249","author":"Yang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00125-022-05814-2","article-title":"Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes","volume":"66","author":"Brusco","year":"2022","journal-title":"Diabetologia"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/S0140-6736(16)30507-4","article-title":"Environmental risk factors for type 1 diabetes","volume":"387","author":"Rewers","year":"2016","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling\u2014From basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2018","journal-title":"FEBS J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1038\/s41467-022-32425-7","article-title":"Adaptation to chronic ER stress enforces pancreatic \u03b2-cell plasticity","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.cmet.2020.03.002","article-title":"Beta Cell Dedifferentiation Induced by IRE1\u03b1 Deletion Prevents Type 1 Diabetes","volume":"31","author":"Lee","year":"2020","journal-title":"Cell Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s00125-022-05669-7","article-title":"XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice","volume":"65","author":"Lee","year":"2022","journal-title":"Diabetologia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101338","DOI":"10.1016\/j.molmet.2021.101338","article-title":"ATF4-mediated transcriptional regulation protects against \u03b2-cell loss during endoplasmic reticulum stress in a mouse model","volume":"54","author":"Kitakaze","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"E448","DOI":"10.1152\/ajpendo.00156.2023","article-title":"Endoplasmic reticulum stress in pancreatic \u03b2 cells induces incretin desensitization and \u03b2-cell dysfunction via ATF4-mediated PDE4D expression","volume":"325","author":"Lee","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"bqac184","DOI":"10.1210\/endocr\/bqac184","article-title":"Inside the \u03b2 Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis","volume":"164","author":"Kulkarni","year":"2022","journal-title":"Endocrinology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Koryga","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbagen.2018.12.009","article-title":"M(en)TORship lessons on life and death by the integrated stress response","volume":"1863","author":"Koromilas","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"25254","DOI":"10.1074\/jbc.M109.000877","article-title":"Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p","volume":"284","author":"Zaborske","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tem.2009.05.008","article-title":"ATF4-dependent transcription mediates signaling of amino acid limitation","volume":"20","author":"Kilberg","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_86","first-page":"e128820","article-title":"GCN2 regulates pancreatic \u03b2 cell mass by sensing intracellular amino acid levels","volume":"5","author":"Kanno","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"104125","DOI":"10.1016\/j.isci.2022.104125","article-title":"Calcineurin\/NFATc2 and PI3K\/AKT signaling maintains \u03b2-cell identity and function during metabolic and inflammatory stress","volume":"25","author":"Darden","year":"2022","journal-title":"iScience"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.2147\/DMSO.S257797","article-title":"Endoplasmic Reticulum (ER) Stress in Part Mediates Effects of Angiotensin II in Pancreatic Beta Cells","volume":"13","author":"Ramalingam","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s10020-018-0044-3","article-title":"Reversal of angiotensin ll-induced \u03b2-cell dedifferentiation via inhibition of NF-\u03bab signaling","volume":"24","author":"Chen","year":"2018","journal-title":"Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Li, M.-Y., Liu, L.-Z., Xin, Q., Zhou, J., Zhang, X., Zhang, R., Wu, Z., Yi, J., and Dong, M. (2023). Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet \u03b2-cell apoptosis and dysfunction. Biochim. Biophys. Acta (BBA) Mol. Cell Biol. Lipids, 1868.","DOI":"10.1016\/j.bbalip.2023.159332"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jgg.2021.11.006","article-title":"GRB10 regulates \u03b2-cell mass by inhibiting \u03b2-cell proliferation and stimulating \u03b2-cell dedifferentiation","volume":"49","author":"Cai","year":"2022","journal-title":"J. Genet. Genom."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41467-020-15935-0","article-title":"Raptor determines \u03b2-cell identity and plasticity independent of hyperglycemia in mice","volume":"11","author":"Yin","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101559","DOI":"10.1016\/j.molmet.2022.101559","article-title":"mTORC1 is required for epigenetic silencing during \u03b2-cell functional maturation","volume":"64","author":"Ni","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Cui, C., Li, T., Xie, Y., Yang, J., Fu, C., Qiu, Y., Shen, L., Ni, Q., Wang, Q., and Nie, A. (2021). Enhancing Acsl4 in absence of mTORC2\/Rictor drove \u03b2-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production. Biochim. Biophys. Acta (BBA) Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2021.166261"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"109490","DOI":"10.1016\/j.celrep.2021.109490","article-title":"Inhibition of PHLPP1\/2 phosphatases rescues pancreatic \u03b2-cells in diabetes","volume":"36","author":"Lupse","year":"2021","journal-title":"Cell Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"147191","DOI":"10.1016\/j.gene.2023.147191","article-title":"Biomedical importance of the ubiquitin\u2013proteasome system in diabetes and metabolic transdifferentiation of pancreatic duct epithelial cells into \u03b2-cells","volume":"858","author":"Liu","year":"2023","journal-title":"Gene"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2174\/1389203723666220422092023","article-title":"Dynamics of Ubiquitination in Differentiation and Dedifferentiation of Pancreatic \u03b2-cells: Putative Target for Diabetes","volume":"23","author":"Kumar","year":"2022","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"106771","DOI":"10.1016\/j.isci.2023.106771","article-title":"Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic \u03b2-cells","volume":"26","author":"Francis","year":"2023","journal-title":"iScience"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/s41467-023-38146-9","article-title":"USP7 controls NGN3 stability and pancreatic endocrine lineage development","volume":"14","author":"Manea","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/s12276-023-01035-8","article-title":"Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs","volume":"55","author":"Cho","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_101","first-page":"2592","article-title":"Pax4 synergistically acts with Pdx1, Ngn3 and MafA to induce HuMSCs to differentiate into functional pancreatic \u03b2-cells","volume":"18","author":"Zhang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Lorenzo, P.I., Ju\u00e1rez-Vicente, F., Cobo-Vuilleumier, N., Garc\u00eda-Dom\u00ednguez, M., and Gauthier, B.R. (2017). The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences. Genes, 8.","DOI":"10.3390\/genes8030101"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.200405148","article-title":"The diabetes-linked transcription factor PAX4 promotes \u03b2-cell proliferation and survival in rat and human islets","volume":"167","author":"Brun","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Parajuli, K.R., Zhang, Y., Cao, A.M., Wang, H., Fonseca, V.A., and Wu, H. (2020). Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting \u03b2 Cell Survival and \u03b1-to-\u03b2 Cell Transdifferentiation. Cell Transplant., 29.","DOI":"10.1177\/0963689720958655"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1210\/clinem\/dgaa563","article-title":"NKX2-2 Mutation Causes Congenital Diabetes and Infantile Obesity With Paradoxical Glucose-Induced Ghrelin Secretion","volume":"105","author":"Auerbach","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.2337\/db06-1766","article-title":"Nkx2. 2 regulates \u03b2-cell function in the mature islet","volume":"56","author":"Doyle","year":"2007","journal-title":"Diabetes"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1101\/gad.173039.111","article-title":"Nkx2. 2 repressor complex regulates islet \u03b2-cell specification and prevents \u03b2-to-\u03b1-cell reprogramming","volume":"25","author":"Papizan","year":"2011","journal-title":"Genes Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"31236","DOI":"10.1074\/jbc.M109.048694","article-title":"Cooperative Transcriptional Regulation of the Essential Pancreatic Islet Gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3","volume":"284","author":"Anderson","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_109","first-page":"244","article-title":"Pancreatic \u03b2 cell identity requires continual repression of non\u2013\u03b2 cell programs","volume":"127","author":"Bender","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Fontcuberta-PiSunyer, M., Garc\u00eda-Alam\u00e1n, A., Prades, \u00c8., T\u00e9llez, N., Alves-Figueiredo, H., Ramos-Rodr\u00edguez, M., Enrich, C., Fernandez-Ruiz, R., Cervantes, S., and Clua, L. (2023). Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-04627-2"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1242\/dev.126011","article-title":"Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing \u03b2-cells to a \u03b4-like fate and reveals a facultative proliferative capacity in aged \u03b2-cells","volume":"142","author":"Pan","year":"2015","journal-title":"Development"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cmet.2013.11.021","article-title":"Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man","volume":"19","author":"Flanagan","year":"2014","journal-title":"Cell Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ydbio.2012.03.001","article-title":"Characterization and regulation of the hb9\/mnx1 beta-cell progenitor specific enhancer in zebrafish","volume":"365","author":"Arkhipova","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1242\/dev.067736","article-title":"Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas","volume":"138","author":"Dalgin","year":"2011","journal-title":"Development"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4161\/isl.21984","article-title":"Mnx1: A gatekeeper of \u03b2 cell fate","volume":"4","author":"Dalgin","year":"2012","journal-title":"Islets"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3892\/etm.2021.10139","article-title":"Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus (Review)","volume":"22","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2005.08.004","article-title":"FoxO1 protects against pancreatic \u03b2 cell failure through NeuroD and MafA induction","volume":"2","author":"Kitamura","year":"2005","journal-title":"Cell Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"101329","DOI":"10.1016\/j.molmet.2021.101329","article-title":"An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation","volume":"54","author":"Casteels","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/s13287-020-02007-9","article-title":"Mesenchymal stem cells promote pancreatic \u03b2-cell regeneration through downregulation of FoxO1 pathway","volume":"11","author":"Khatri","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00592-023-02221-w","article-title":"Downregulation of Sirt3 contributes to \u03b2-cell dedifferentiation via FoxO1 in type 2 diabetic mellitus","volume":"61","author":"Nie","year":"2023","journal-title":"Acta Diabetol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1074\/jbc.RA119.007755","article-title":"MicroRNA-223 is essential for maintaining functional \u03b2-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_122","first-page":"2324","article-title":"Osteoprotegerin promotes islet \u03b2 cell proliferation in intrauterine growth retardation rats through the PI3K\/AKT\/FoxO1 pathway","volume":"12","author":"Tang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_123","first-page":"E97","article-title":"Glucagon receptor blockage inhibits \u03b2-cell dedifferentiation through FoxO1","volume":"324","author":"Wang","year":"2023","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ebrahim, N., Shakirova, K., and Dashinimaev, E. (2022). PDX1 is the cornerstone of pancreatic \u03b2-cell functions and identity. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.1091757"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00125-015-3805-3","article-title":"Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models","volume":"59","author":"Chen","year":"2015","journal-title":"Diabetologia"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Fang, X., Wei, J., Miao, R., Wu, H., Ma, K., and Tian, J. (2022). PDX-1: A Promising Therapeutic Target to Reverse Diabetes. Biomolecules, 12.","DOI":"10.3390\/biom12121785"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cmet.2023.11.018","article-title":"Repression of latent NF-\u03baB enhancers by PDX1 regulates \u03b2 cell functional heterogeneity","volume":"36","author":"Weidemann","year":"2024","journal-title":"Cell Metab."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e56227","DOI":"10.15252\/embr.202256227","article-title":"Hypoxia causes pancreatic \u03b2-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40","volume":"24","author":"Tsuyama","year":"2023","journal-title":"EMBO Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"22612","DOI":"10.1074\/jbc.M802902200","article-title":"MafA and MafB Regulate Pdx1 Transcription through the Area II Control Region in Pancreatic \u03b2 Cells","volume":"283","author":"Vanhoose","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s13287-020-01977-0","article-title":"NKX6. 1 transcription factor: A crucial regulator of pancreatic \u03b2 cell development, identity, and proliferation","volume":"11","author":"Aigha","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Luan, C., Ye, Y., Singh, T., Barghouth, M., Eliasson, L., Artner, I., Zhang, E., and Renstr\u00f6m, E. (2019). The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification. Commun. Biol., 2.","DOI":"10.1038\/s42003-019-0351-4"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Liang, J., Chirikjian, M., Pajvani, U.B., and Bartolom\u00e9, A. (2022). MafA Regulation in \u03b2-Cells: From Transcriptional to Post-Translational Mechanisms. Biomolecules, 12.","DOI":"10.3390\/biom12040535"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Nishimura, W., Iwasa, H., and Tumurkhuu, M. (2022). Role of the Transcription Factor MAFA in the Maintenance of Pancreatic \u03b2-Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094478"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.2337\/db13-1001","article-title":"The MafA Transcription Factor Becomes Essential to Islet \u03b2-Cells Soon After Birth","volume":"63","author":"Hang","year":"2014","journal-title":"Diabetes"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Eto, K., Nishimura, W., Oishi, H., Udagawa, H., Kawaguchi, M., Hiramoto, M., Fujiwara, T., Takahashi, S., and Yasuda, K. (2014). MafA Is Required for Postnatal Proliferation of Pancreatic \u03b2-Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104184"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13287-017-0694-z","article-title":"PDX1, Neurogenin-3, and MAFA: Critical transcription regulators for beta cell development and regeneration","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"101313","DOI":"10.1016\/j.molmet.2021.101313","article-title":"Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network","volume":"53","author":"Schreiber","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1073\/pnas.1004842108","article-title":"Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a","volume":"108","author":"Miyatsuka","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biocel.2011.09.008","article-title":"SOX9 regulates endocrine cell differentiation during human fetal pancreas development","volume":"44","author":"McDonald","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s12015-021-10232-9","article-title":"New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells","volume":"17","author":"Dettmer","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"113406","DOI":"10.1016\/j.yexcr.2022.113406","article-title":"Sox9 is required in regeneration of pancreatic \u03b2 cells following injury","volume":"422","author":"Wang","year":"2023","journal-title":"Exp. Cell Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1073\/pnas.1524200113","article-title":"Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into \u03b2 cells in mice with reversal of diabetes","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e170884","DOI":"10.1172\/jci.insight.170884","article-title":"HNF1\u03b1 maintains pancreatic \u03b1 and \u03b2 cell functions in primary human islets","volume":"8","author":"Qian","year":"2023","journal-title":"JCI Insight"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Sato, Y., Rahman, M., Haneda, M., Tsuyama, T., Mizumoto, T., Yoshizawa, T., Kitamura, T., Gonzalez, F.J., Yamamura, K.-I., and Yamagata, K. (2020). HNF1\u03b1 controls glucagon secretion in pancreatic \u03b1-cells through modulation of SGLT1. Biochim. Biophys. Acta (BBA) Mol. Basis Dis., 1866.","DOI":"10.1016\/j.bbadis.2020.165898"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1038\/s41467-021-22843-4","article-title":"Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3\/HNF1A hiPSC-derived mutant \u03b2 cells","volume":"12","author":"Low","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Chen, Y., Jia, J., Zhao, Q., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M., and Li, X. (2022). Novel Loss-of-Function Variant in HNF1a Induces \u03b2-Cell Dysfunction through Endoplasmic Reticulum Stress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113022"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"110425","DOI":"10.1016\/j.celrep.2022.110425","article-title":"An HNF1\u03b1 truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1\u03b2 function","volume":"38","author":"Cujba","year":"2022","journal-title":"Cell Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbrc.2020.05.155","article-title":"Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth","volume":"529","author":"Sujjitjoon","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"20698","DOI":"10.1038\/srep20698","article-title":"Redifferentiation of expanded human islet \u03b2 cells by inhibition of ARX","volume":"6","author":"Elkon","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/981569","article-title":"Pax4 and Arx Represent Crucial Regulators of the Development of the Endocrine Pancreas","volume":"2014","author":"Courtney","year":"2014","journal-title":"New J. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"\u0110or\u0111evi\u0107, M., Stepper, P., Feuerstein-Akgoz, C., Gerhauser, C., Paunovi\u0107, V., Toli\u0107, A., Raji\u0107, J., Dini\u0107, S., Uskokovi\u0107, A., and Grdovi\u0107, N. (2023). EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1134478"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Courtney, M., Gjernes, E., Druelle, N., Ravaud, C., Vieira, A., Ben-Othman, N., Pfeifer, A., Avolio, F., Leuckx, G., and Lacas-Gervais, S. (2013). The Inactivation of Arx in Pancreatic \u03b1-Cells Triggers Their Neogenesis and Conversion into Functional \u03b2-like Cells. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003934"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/db17-0364","article-title":"GATA6 Controls Insulin Biosynthesis and Secretion in Adult \u03b2-Cells","volume":"67","author":"Villamayor","year":"2017","journal-title":"Diabetes"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.stemcr.2018.12.003","article-title":"GATA6 cooperates with EOMES\/SMAD2\/3 to deploy the gene regulatory network governing human definitive endoderm and pancreas formation","volume":"12","author":"Chia","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stemcr.2016.12.026","article-title":"GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic \u03b2 Cells","volume":"8","author":"Tiyaboonchai","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/jc.2017-01159","article-title":"Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA","volume":"103","author":"Sanyoura","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12033-023-00761-8","article-title":"Monogenic Diabetes with GATA6 Mutations: Characterization of a Novel Family and a Comprehensive Analysis of the GATA6 Clinical and Genetics Traits","volume":"66","author":"Yue","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10059-012-0109-z","article-title":"Glis3 Regulates Neurogenin 3 Expression in Pancreatic \u03b2-Cells and Interacts with Its Activator, Hnf6","volume":"34","author":"Kim","year":"2012","journal-title":"Mol. Cells"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-19-0182","article-title":"GLIS3 binds pancreatic beta cell regulatory regions alongside other islet transcription factors","volume":"243","author":"Scoville","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1038\/s41467-018-04918-x","article-title":"Discovery of a drug candidate for GLIS3-associated diabetes","volume":"9","author":"Amin","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00125-023-06035-x","article-title":"Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas","volume":"67","author":"Meulebrouck","year":"2023","journal-title":"Diabetologia"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2344622","DOI":"10.1080\/19382014.2024.2344622","article-title":"Downregulation of Glis3 in INS1 cells exposed to chronically elevated glucose contributes to glucotoxicity-associated \u03b2 cell dysfunction","volume":"16","author":"Grieve","year":"2024","journal-title":"Islets"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1172\/JCI88015","article-title":"PAX6 maintains \u03b2 cell identity by repressing genes of alternative islet cell types","volume":"127","author":"Swisa","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1210\/me.2011-1256","article-title":"Pax6 is crucial for \u03b2-cell function, insulin biosynthesis, and glucose-induced insulin secretion","volume":"26","author":"Gosmain","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ydbio.2004.01.040","article-title":"Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes","volume":"269","author":"Zhou","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.7150\/thno.51857","article-title":"Smad3 deficiency promotes beta cell proliferation and function in db\/db mice via restoring Pax6 expression","volume":"11","author":"Sheng","year":"2021","journal-title":"Theranostics"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"dev201009","DOI":"10.1242\/dev.201009","article-title":"MafB-dependent neurotransmitter signaling promotes \u03b2 cell migration in the developing pancreas","volume":"150","author":"Bsharat","year":"2023","journal-title":"Development"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db18-0903","article-title":"Examining How the MAFB Transcription Factor Affects Islet \u03b2-Cell Function Postnatally","volume":"68","author":"Cyphert","year":"2018","journal-title":"Diabetes"},{"key":"ref_170","first-page":"e166386","article-title":"Species-specific roles for the MAFA and MAFB transcription factors in regulating islet \u03b2 cell identity","volume":"8","author":"Cha","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1038\/s41467-020-16550-9","article-title":"Loss of the transcription factor MAFB limits \u03b2-cell derivation from human PSCs","volume":"11","author":"Russell","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"17269","DOI":"10.1074\/jbc.M111.319152","article-title":"Redifferentiation of Expanded Human Pancreatic \u03b2-Cell-derived Cells by Inhibition of the NOTCH Pathway","volume":"287","author":"Bar","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2337\/db07-1323","article-title":"HES-1 Is Involved in Adaptation of Adult Human \u03b2-Cells to Proliferation In Vitro","volume":"57","author":"Bar","year":"2008","journal-title":"Diabetes"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1053\/j.gastro.2022.08.048","article-title":"Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation","volume":"163","author":"Marui","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e2305631","DOI":"10.1002\/advs.202305631","article-title":"LINC MIR503HG Controls SC-\u03b2 Cell Differentiation and Insulin Production by Targeting CDH1 and HES1","volume":"11","author":"Xu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"120213","DOI":"10.1016\/j.lfs.2021.120213","article-title":"Hepatocyte Nuclear Factor 4-\u03b1 (HNF4\u03b1) controls the insulin resistance-induced pancreatic \u03b2-cell mass expansion","volume":"289","author":"Barth","year":"2022","journal-title":"Life Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"13983","DOI":"10.1074\/jbc.RA119.009558","article-title":"ErbB3-binding protein 1 (EBP1) represses HNF4\u03b1-mediated transcription and insulin secretion in pancreatic \u03b2-cells","volume":"294","author":"Han","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.2337\/db19-0117","article-title":"Murine Perinatal \u03b2-Cell Proliferation and the Differentiation of Human Stem Cell\u2013Derived Insulin-Expressing Cells Require NEUROD1","volume":"68","author":"Romer","year":"2019","journal-title":"Diabetes"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1038\/s41467-023-41306-6","article-title":"NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development","volume":"14","author":"Bohuslavova","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cmet.2010.03.006","article-title":"Pancreatic \u03b2 Cells Require NeuroD to Achieve and Maintain Functional Maturity","volume":"11","author":"Gu","year":"2010","journal-title":"Cell Metab."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Schaffer, A.E., Taylor, B.L., Benthuysen, J.R., Liu, J., Thorel, F., Yuan, W., Jiao, Y., Kaestner, K.H., Herrera, P.L., and Magnuson, M.A. (2013). Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003274"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e3400","DOI":"10.1002\/dmrr.3400","article-title":"PDX1\u2212\/NKX6. 1+ progenitors derived from human pluripotent stem cells as a novel source of insulin-secreting cells","volume":"37","author":"Memon","year":"2021","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"17796","DOI":"10.1038\/s41598-021-97235-1","article-title":"Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects","volume":"11","author":"Fujita","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1073\/pnas.1320953111","article-title":"Nkx6.1 regulates islet \u03b2-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors","volume":"111","author":"Tessem","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Ratiu, J., Southard, S.M., and Rust, W.L. (2023). The transcription factors ISL-1 and MAFA, but not NKX6-1 Characterize a Stem-cell Derived Population of Endocrine Pancreatic Cells Capable of Controlling blood Glucose in Rodent Models of Diabetes. Med. Res. Arch., 11.","DOI":"10.18103\/mra.v11i12.4797"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhang, R., Liu, C., Ge, X., Wang, Y., Jiang, F., Zhuang, L., Li, T., Zhu, Q., and Jiang, Y. (2024). Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes. Diabetologia.","DOI":"10.1007\/s00125-024-06186-5"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Bohuslavova, R., Fabriciova, V., Lebr\u00f3n-Mora, L., Malfatti, J., Smolik, O., Valihrach, L., Benesova, S., Zucha, D., Berkova, Z., and Saudek, F. (2023). ISL1 controls pancreatic alpha cell fate and beta cell maturation. Cell Biosci., 13.","DOI":"10.1186\/s13578-023-01003-9"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Guo, T., Wang, W., Zhang, H., Liu, Y., Chen, P., Ma, K., and Zhou, C. (2011). ISL1 Promotes Pancreatic Islet Cell Proliferation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022387"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2337\/db23-0148","article-title":"A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates \u03b2-Cell Identity and Function","volume":"73","author":"Connors","year":"2023","journal-title":"Diabetes"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1530\/EC-21-0260","article-title":"Targeting \u03b2-cell dedifferentiation and transdifferentiation: Opportunities and challenges","volume":"10","author":"Wang","year":"2021","journal-title":"Endocr. Connect."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"101493","DOI":"10.1016\/j.molmet.2022.101493","article-title":"Autotaxin signaling facilitates \u03b2 cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency","volume":"60","author":"Cao","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41419-021-03761-1","article-title":"CBP\/p300 HAT maintains the gene network critical for \u03b2 cell identity and functional maturity","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00125-023-05896-6","article-title":"Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice","volume":"66","author":"Vanderkruk","year":"2023","journal-title":"Diabetologia"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-023-01707-x","article-title":"EZH2 inhibitors promote \u03b2-like cell regeneration in young and adult type 1 diabetes donors","volume":"9","author":"Marikar","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Parveen, N., and Dhawan, S. (2021). DNA Methylation Patterning and the Regulation of Beta Cell Homeostasis. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.651258"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2337\/db22-0506","article-title":"DNA Methylation-Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic \u03b2-Cell Heterogeneity","volume":"72","author":"Parveen","year":"2023","journal-title":"Diabetes"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"111581","DOI":"10.1016\/j.celrep.2022.111581","article-title":"Arid1a loss potentiates pancreatic \u03b2-cell regeneration through activation of EGF signaling","volume":"41","author":"Celen","year":"2022","journal-title":"Cell Rep."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.2337\/db19-0349","article-title":"The Pdx1-Bound Swi\/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet \u03b2-Cell Function","volume":"68","author":"Spaeth","year":"2019","journal-title":"Diabetes"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2337\/db22-0939","article-title":"The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for \u03b2-Cell Function In Vivo","volume":"72","author":"Davidson","year":"2023","journal-title":"Diabetes"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1530\/JME-22-0011","article-title":"The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in \u03b2-cell function","volume":"69","author":"Davidson","year":"2022","journal-title":"J. Mol. Endocrinol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2174\/1389450121666191230145848","article-title":"The Predominant microRNAs in \u03b2-cell Clusters for Insulin Regulation and Diabetic Control","volume":"21","author":"Soltani","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Sebastiani, G., Grieco, G.E., Brusco, N., Ventriglia, G., Formichi, C., Marselli, L., Marchetti, P., and Dotta, F. (2018). MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041170"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Melnik, B.C., and Schmitz, G. (2022). Milk Exosomal microRNAs: Postnatal Promoters of \u03b2 Cell Proliferation but Potential Inducers of \u03b2 Cell De-Differentiation in Adult Life. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911503"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12986-019-0412-1","article-title":"Milk exosomal miRNAs: Potential drivers of AMPK-to-mTORC1 switching in \u03b2-cell de-differentiation of type 2 diabetes mellitus","volume":"16","author":"Melnik","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"bqab031","DOI":"10.1210\/endocr\/bqab031","article-title":"microRNA-483 Protects Pancreatic \u03b2-Cells by Targeting ALDH1A3","volume":"162","author":"Wang","year":"2021","journal-title":"Endocrinology"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"19955","DOI":"10.1074\/jbc.M115.650705","article-title":"Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic \u03b2- and \u03b1-Cells","volume":"290","author":"Mohan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"bqab067","DOI":"10.1210\/endocr\/bqab067","article-title":"Micro-RNA-mediated Maintenance of Beta-cell Identity Reveals Targets for Reversing Beta-cell Dedifferentiation","volume":"162","author":"Gannon","year":"2021","journal-title":"Endocrinology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"108576","DOI":"10.1016\/j.celrep.2020.108576","article-title":"Expression of miRNA-29 in Pancreatic \u03b2 Cells Promotes Inflammation and Diabetes via TRAF3","volume":"34","author":"Sun","year":"2021","journal-title":"Cell Rep."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e12055","DOI":"10.1002\/jev2.12055","article-title":"Pancreatic \u03b2 cells control glucose homeostasis via the secretion of exosomal miR-29 family","volume":"10","author":"Li","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Lang, H., Lin, N., Chen, X., Xiang, J., Zhang, X., and Kang, C. (2024). Repressing miR-23a promotes the transdifferentiation of pancreatic \u03b1 cells to \u03b2 cells via negatively regulating the expression of SDF-1\u03b1. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0299821"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/jmcb\/mjz004","article-title":"MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis","volume":"11","author":"Zhu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"101248","DOI":"10.1016\/j.molmet.2021.101248","article-title":"Dysregulation of the Pdx1\/Ovol2\/Zeb2 axis in dedifferentiated \u03b2-cells triggers the induction of genes associated with epithelial\u2013mesenchymal transition in diabetes","volume":"53","author":"Mak","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s11626-021-00611-4","article-title":"MicroRNA-7a inhibits Isl1 expression to regulate insulin secretion by targeting Raf1 and Mapkap1 in NIT-1 cells","volume":"57","author":"Liu","year":"2021","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12020-022-03016-9","article-title":"miR-25 and miR-92b regulate insulin biosynthesis and pancreatic \u03b2-cell apoptosis","volume":"76","author":"Shen","year":"2022","journal-title":"Endocrine"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s13105-018-0615-3","article-title":"Identification of miR-9 as a negative factor of insulin secretion from beta cells","volume":"74","author":"Hu","year":"2018","journal-title":"J. Physiol. Biochem."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/biof.1461","article-title":"microRNA-96 protects pancreatic \u03b2-cell function by targeting PAK1 in gestational diabetes mellitus","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-020-00618-8","article-title":"MicroRNA-33a-5p sponges to inhibit pancreatic \u03b2-cell function in gestational diabetes mellitus LncRNA DANCR","volume":"18","author":"Feng","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Li, Y., Yang, Y., Sun, Y., He, L., Liu, K., Zhang, Y., Zhou, Y., Chang, X., Liang, R., and Wang, S. (2023). The miR-203\/ZBTB20\/MAFA Axis Orchestrates Pancreatic \u03b2-Cell Maturation and Identity During Weaning and Diabetes. SSRN, 4467623.","DOI":"10.2139\/ssrn.4467623"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41467-020-15529-w","article-title":"Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.1038\/s41598-022-16174-7","article-title":"Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity","volume":"12","author":"Mao","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Bai, C., Ren, Q., Liu, H., Li, X., Guan, W., and Gao, Y. (2021). miR-212\/132-enriched extracellular vesicles promote differentiation of induced pluripotent stem cells into pancreatic beta cells. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.673231"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1154-8","article-title":"microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9","volume":"10","author":"Xu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"109540","DOI":"10.1016\/j.isci.2024.109540","article-title":"Islet-resident macrophage-derived miR-155 promotes \u03b2 cell decompensation via targeting PDX1","volume":"27","author":"Zhang","year":"2024","journal-title":"iScience"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"154335","DOI":"10.1016\/j.metabol.2020.154335","article-title":"Inhibition of miR-153, an IL-1\u03b2-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes","volume":"111","author":"Sun","year":"2020","journal-title":"Metabolism"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.omtn.2021.08.027","article-title":"miR-320a induces pancreatic \u03b2 cells dysfunction in diabetes by inhibiting MafF","volume":"26","author":"Du","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Wan, S., Zhang, J., Chen, X., Lang, J., Li, L., Chen, F., Tian, L., Meng, Y., and Yu, X. (2020). MicroRNA-17-92 Regulates Beta-Cell Restoration After Streptozotocin Treatment. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00009"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"694.13","DOI":"10.1096\/fasebj.2019.33.1_supplement.694.13","article-title":"MiR-21 Contributes to Cytokine-Induced Beta Cell Dysfunction via Inhibition of mRNAs Regulating Beta Cell Identity","volume":"33","author":"Ibrahim","year":"2019","journal-title":"FASEB J."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Ibrahim, S. (2020). miR-21 Exacerbates Cytokine Induced Beta Cell Dysfunction via Inhibition of mRNAs Regulating Beta Cell Identity. [Ph.D. Thesis, Indiana University-Purdue University Indianapolis].","DOI":"10.1096\/fasebj.2019.33.1_supplement.694.13"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41420-022-01142-x","article-title":"Reduced miR-184-3p expression protects pancreatic \u03b2-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation","volume":"8","author":"Grieco","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/2211536605666160607082214","article-title":"Enhanced Expression of miR-199b-5p Promotes Proliferation of Pancreatic.\u03b2-Cells by Down-Regulation of MLK3","volume":"5","author":"Yoshida","year":"2016","journal-title":"MicroRNA"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00125-021-05489-1","article-title":"M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt\/GSK-3\u03b2\/\u03b2-catenin pathway in mice","volume":"64","author":"Qian","year":"2021","journal-title":"Diabetologia"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mce.2017.02.043","article-title":"The small RNA miR-375\u2014A pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function","volume":"456","author":"Eliasson","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_234","first-page":"254","article-title":"miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression","volume":"3","author":"Li","year":"2010","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.25011\/cim.v41i1.29459","article-title":"MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic \u03b2-cells in high-fat-diet-fed mice","volume":"41","author":"Guo","year":"2018","journal-title":"Clin. Investig. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2174\/1871530323666230206121715","article-title":"Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet \u03b2 Cells","volume":"23","author":"Lin","year":"2023","journal-title":"Endocrine, Metab. Immune Disord. Drug Targets"},{"key":"ref_237","first-page":"1","article-title":"miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages","volume":"2021","author":"Lu","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/19382014.2022.2060688","article-title":"Dual regulation of miR-375 and CREM genes in pancreatic beta cells","volume":"14","author":"Keller","year":"2022","journal-title":"Islets"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Nathan, G., Kredo-Russo, S., Geiger, T., Lenz, A., Kaspi, H., Hornstein, E., and Efrat, S. (2015). MiR-375 Promotes Redifferentiation of Adult Human \u03b2 Cells Expanded In Vitro. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122108"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"101267","DOI":"10.1016\/j.molmet.2021.101267","article-title":"The miR-200\u2013Zeb1 axis regulates key aspects of \u03b2-cell function and survival in vivo","volume":"53","author":"Title","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02371-0","article-title":"Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic \u03b2-cell dedifferentiation","volume":"12","author":"He","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/oby.23360","article-title":"MiR-195 promotes pancreatic \u03b2-cell dedifferentiation by targeting Mfn2 and impairing Pi3k\/Akt signaling in type 2 diabetes","volume":"30","author":"Xu","year":"2022","journal-title":"Obesity"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Sisino, G., Zhou, A.-X., Dahr, N., Sabirsh, A., Soundarapandian, M.M., Perera, R., Larsson-Lekholm, E., Magnone, M.C., Althage, M., and Tyrberg, B. (2017). Long noncoding RNAs are dynamically regulated during \u03b2-cell mass expansion in mouse pregnancy and control \u03b2-cell proliferation in vitro. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182371"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"L\u00f3pez\u2013Noriega, L., and Rutter, G.A. (2021). Long Non-Coding RNAs as Key Modulators of Pancreatic \u03b2-Cell Mass and Function. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.610213"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2337\/db11-1314","article-title":"Transgenerational glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia","volume":"61","author":"Ding","year":"2012","journal-title":"Diabetes"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2337\/db18-0201","article-title":"Contribution of the Long Noncoding RNA H19 to \u03b2-Cell Mass Expansion in Neonatal and Adult Rodents","volume":"67","author":"Jacovetti","year":"2018","journal-title":"Diabetes"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.2147\/DMSO.S273586","article-title":"Assessment of Cell-Free Long Non-Coding RNA-H19 and miRNA-29a, miRNA-29b Expression and Severity of Diabetes","volume":"13","author":"Alfaifi","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_248","first-page":"E846","article-title":"The long noncoding RNA TUNAR modulates Wnt signaling and regulates human \u03b2-cell proliferation","volume":"320","author":"Zhou","year":"2021","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/jcp.25175","article-title":"Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells","volume":"231","author":"You","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1159\/000487983","article-title":"Long Noncoding RNA Meg3 Regulates Mafa Expression in Mouse Beta Cells by Inactivating Rad21, Smc3 or Sin3\u03b1","volume":"45","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1038\/s41467-021-24302-6","article-title":"The long non-coding RNA \u03b2Faar regulates islet \u03b2-cell function and survival during obesity in mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00438-022-01922-1","article-title":"Long non-coding RNAs: A valuable biomarker for metabolic syndrome","volume":"297","author":"Rashidmayvan","year":"2022","journal-title":"Mol. Genet. Genom."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Huang, Y., Xu, Y., Lu, Y., Zhu, S., Guo, Y., Sun, C., Xu, L., Chen, X., Zhao, Y., and Yu, B. (2019). lncRNA Gm10451 regulates PTIP to facilitate iPSCs-derived \u03b2-like cell differentiation by targeting miR-338-3p as a ceRNA. Biomaterials, 216.","DOI":"10.1016\/j.biomaterials.2019.119266"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00125-020-05090-y","article-title":"Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation","volume":"63","author":"Zhang","year":"2020","journal-title":"Diabetologia"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000488434","article-title":"Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet \u03b2-Cell Function","volume":"46","author":"Ruan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_256","first-page":"156","article-title":"Elevated Circulating LINC-P21 Serves as a Diagnostic Biomarker of Type 2 Diabetes Mellitus and Regulates Pancreatic \u03b2-cell Function by Sponging miR-766-3p to Upregulate NR3C2","volume":"130","author":"Cao","year":"2020","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"101878","DOI":"10.1016\/j.molmet.2024.101878","article-title":"Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic \u03b2 cell function","volume":"80","author":"Wang","year":"2024","journal-title":"Mol. Metab."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"104432","DOI":"10.1016\/j.yexmp.2020.104432","article-title":"LncRNA MALAT1 induces the dysfunction of \u03b2 cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes","volume":"114","author":"Ding","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Luo, Y., Guo, J., Xu, P., and Gui, R. (2020). Long non-coding RNA GAS5 maintains insulin secretion by regulating multiple miRNAs in INS-1 832\/13 cells. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.559267"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1159\/000484191","article-title":"Downregulation of Long Noncoding RNA Gas5 Affects Cell Cycle and Insulin Secretion in Mouse Pancreatic \u03b2 Cells","volume":"43","author":"Jin","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1055\/a-2077-5177","article-title":"LncRNA LINC01018 Screens Type 2 Diabetes Mellitus and Regulates \u03b2 Cell Function Through Modulating miR-499a-5p","volume":"55","author":"Liu","year":"2023","journal-title":"Horm. Metab. Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"e67576","DOI":"10.7554\/eLife.67576","article-title":"A \u03b4-cell subpopulation with a pro-\u03b2-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes","volume":"11","author":"Pardo","year":"2022","journal-title":"eLife"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"dev199853","DOI":"10.1242\/dev.199853","article-title":"A single-cell atlas of de novo \u03b2-cell regeneration reveals the contribution of hybrid \u03b2\/\u03b4-cells to diabetes recovery in zebrafish","volume":"149","author":"Singh","year":"2022","journal-title":"Development"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s42255-021-00364-0","article-title":"Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas","volume":"3","author":"Zhao","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"e1357","DOI":"10.1038\/cddis.2014.311","article-title":"Pharmacological induction of pancreatic islet cell transdifferentiation: Relevance to type I diabetes","volume":"5","author":"Piran","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13633","article-title":"Diabetes recovery by age-dependent conversion of pancreatic \u03b4-cells into insulin producers","volume":"514","author":"Chera","year":"2014","journal-title":"Nature"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"9515","DOI":"10.1038\/s41598-019-45853-1","article-title":"Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes","volume":"9","author":"Marroqui","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tem.2011.05.003","article-title":"MafA and MafB activity in pancreatic \u03b2 cells","volume":"22","author":"Hang","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41586-019-0942-8","article-title":"Diabetes relief in mice by glucose-sensing insulin-secreting human \u03b1-cells","volume":"567","author":"Furuyama","year":"2019","journal-title":"Nature"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"dev201306","DOI":"10.1242\/dev.201306","article-title":"Pax4-Ghrelin mediates the conversion of pancreatic \u03b5-cells to \u03b2-cells after extreme \u03b2-cell loss in zebrafish","volume":"150","author":"Yu","year":"2023","journal-title":"Development"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00125-022-05662-0","article-title":"Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system","volume":"65","author":"Sasaki","year":"2022","journal-title":"Diabetologia"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1139\/apnm-2019-0144","article-title":"\u03b2-Cell compensation concomitant with adaptive endoplasmic reticulum stress and \u03b2-cell neogenesis in a diet-induced type 2 diabetes model","volume":"44","author":"Huang","year":"2019","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.stem.2021.08.003","article-title":"Ductal Ngn3-expressing progenitors contribute to adult \u03b2 cell neogenesis in the pancreas","volume":"28","author":"Gribben","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41589-022-01047-x","article-title":"MNK2 deficiency potentiates \u03b2-cell regeneration via translational regulation","volume":"18","author":"Karampelias","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41419-019-1552-y","article-title":"Glutathione prevents chronic oscillating glucose intake-induced \u03b2-cell dedifferentiation and failure","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.diabet.2017.07.006","article-title":"Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic \u03b2 cells under hyperglycaemic stress","volume":"44","author":"John","year":"2018","journal-title":"Diabetes Metab."},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Xing, C., Tang, M., Yang, J., Wang, S., Xu, Q., Feng, W., Mu, Y., Li, F., and Zhao, A.Z. (2023). Eicosapentaenoic acid metabolites promotes the trans-differentiation of pancreatic \u03b1 cells to \u03b2 cells. Biochem. Pharmacol., 216.","DOI":"10.1016\/j.bcp.2023.115775"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1038\/s41467-021-23673-0","article-title":"Reinforcing one-carbon metabolism via folic acid\/Folr1 promotes \u03b2-cell differentiation","volume":"12","author":"Karampelias","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"151612","DOI":"10.1016\/j.acthis.2020.151612","article-title":"Transdifferentiation of both intra- and extra-islet cells into beta cells in nicotinamide treated neonatal diabetic rats: An in situ hybridization and double immunohistochemical study","volume":"122","author":"Ozturk","year":"2020","journal-title":"Acta Histochem."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1021\/acsptsci.3c00218","article-title":"Targeting \u03b2 Cells with Cathelicidin Nanomedicines Improves Insulin Function and Pancreas Regeneration in Type 1 Diabetic Rats","volume":"6","author":"Cristelo","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"155813","DOI":"10.1016\/j.metabol.2024.155813","article-title":"Intermittent fasting protects \u03b2-cell identity and function in a type-2 diabetes model","volume":"153","author":"Patel","year":"2024","journal-title":"Metabolism"},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Li, C., Zhu, J., Wei, S., Ye, X., Yang, L., Wang, Z., and Chen, Y. (2023). Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in \u03b2 cells. J. Nutr. Biochem., 114.","DOI":"10.1016\/j.jnutbio.2023.109275"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"112284","DOI":"10.1016\/j.nut.2023.112284","article-title":"Ketogenic diet alleviates \u03b2-cell dedifferentiation but aggravates hepatic lipid accumulation in db\/db mice","volume":"119","author":"Zhang","year":"2024","journal-title":"Nutrition"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"111744","DOI":"10.1016\/j.foodres.2022.111744","article-title":"A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition","volume":"161","author":"Luo","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Lv, C., Sun, Y., Zhang, Z.Y., Aboelela, Z., Qiu, X., and Meng, Z.-X. (2022). \u03b2-cell dynamics in type 2 diabetes and in dietary and exercise interventions. J. Mol. Cell Biol., 14.","DOI":"10.1093\/jmcb\/mjac046"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13063-021-05207-7","article-title":"The effects of different doses of exercise on pancreatic \u03b2-cell function in patients with newly diagnosed type 2 diabetes: Study protocol for and rationale behind the \"DOSE-EX\" multi-arm parallel-group randomised clinical trial","volume":"22","author":"Lyngbaek","year":"2021","journal-title":"Trials"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"Chow","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_288","first-page":"844","article-title":"Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: A randomized controlled trial","volume":"29","author":"Lehrskov","year":"2019","journal-title":"Yearb. Paediatr. Endocrinol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cmet.2018.04.008","article-title":"Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control","volume":"27","author":"Lehrskov","year":"2018","journal-title":"Cell Metab."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1038\/s41598-018-28117-2","article-title":"Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines","volume":"8","author":"Rutti","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Becic, T., Studenik, C., and Hoffmann, G. (2018). Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Med. Sci., 6.","DOI":"10.3390\/medsci6040097"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","article-title":"Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype","volume":"285","author":"Ohashi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1038\/s41467-020-15833-5","article-title":"Novel metabolic role for BDNF in pancreatic \u03b2-cell insulin secretion","volume":"11","author":"Fulgenzi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"R297","DOI":"10.1152\/ajpregu.00236.2015","article-title":"CX3CL1\u2014A macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle","volume":"310","author":"Olsson","year":"2016","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Liu, S., Du, F., Li, X., Wang, M., Duan, R., Zhang, J., Wu, Y., and Zhang, Q. (2017). Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic \u03b2 cells. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175498"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2337\/db17-0002","article-title":"The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic \u03b2-Cell Survival and Insulin Secretion","volume":"66","author":"Natalicchio","year":"2017","journal-title":"Diabetes"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2337\/db13-0887","article-title":"Osteocalcin Promotes \u03b2-Cell Proliferation During Development and Adulthood Through Gprc6a","volume":"63","author":"Wei","year":"2014","journal-title":"Diabetes"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2015.04.095","article-title":"Osteocalcin protects pancreatic beta cell function and survival under high glucose conditions","volume":"462","author":"Kover","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00125-022-05822-2","article-title":"Pancreatic alpha cell glucagon\u2013liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes","volume":"66","author":"Cui","year":"2022","journal-title":"Diabetologia"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1096\/fj.201802059RRR","article-title":"Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes","volume":"34","author":"Davey","year":"2020","journal-title":"FASEB J."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1113\/EP088220","article-title":"The benefits of physical exercise for the health of the pancreatic \u03b2-cell: A review of the evidence","volume":"105","author":"Curran","year":"2020","journal-title":"Exp. Physiol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1111\/dom.14177","article-title":"Beneficial actions of a long-acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation","volume":"22","author":"Tanday","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/s41467-020-16053-7","article-title":"Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_304","first-page":"73","article-title":"Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis","volume":"168","author":"Vieira","year":"2016","journal-title":"Cell"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cell.2016.11.010","article-title":"Artemisinins Target GABAA Receptor Signaling and Impair \u03b1 Cell Identity","volume":"168","author":"Li","year":"2016","journal-title":"Cell"},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Maykish, A., and Sikalidis, A.K. (2020). Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia\u2014Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation. J. Pers. Med., 10.","DOI":"10.3390\/jpm10010019"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/JOE-19-0451","article-title":"Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes","volume":"245","author":"Tanday","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Tanday, N., Irwin, N., Flatt, P.R., and Moffett, R.C. (2020). Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta-to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance. Biochem. Pharmacol., 177.","DOI":"10.1016\/j.bcp.2020.114009"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"6864","DOI":"10.1038\/s41598-018-25126-z","article-title":"Effect of the sodium\u2013glucose cotransporter 2 inhibitor luseogliflozin on pancreatic beta cell mass in db\/db mice of different ages","volume":"8","author":"Takahashi","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Patel, R., Parmar, N., Rathwa, N., Palit, S.P., Li, Y., Garcia-Oca\u00f1a, A., and Begum, R. (2022). A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic \u03b2-cells in mouse and human islets. Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1869.","DOI":"10.1016\/j.bbamcr.2022.119263"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11892-019-1194-6","article-title":"Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes","volume":"19","author":"Moin","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/JOE-14-0222","article-title":"Gastrin induces ductal cell dedifferentiation and b-cell neogenesis after 90% pancreatectomy","volume":"223","author":"Montanya","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_313","first-page":"9902","article-title":"Maternal serum xenin-25 levels in gestational diabetes mellitus","volume":"27","author":"Kucukbas","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_314","first-page":"OP13-03","article-title":"Thyroid hormone signalling regulates beta-cell pathological growth, dedifferentiation and transdifferentiation in diabetic pancreas","volume":"92","author":"Michele","year":"2023","journal-title":"Endocr. Abstr."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5603\/ep.94750","article-title":"Angiotensin (1\u20137) reverses glucose-induced islet \u03b2 cell dedifferentiation by Wnt\/\u03b2-catenin\/FoxO1 signalling pathway","volume":"74","author":"Guo","year":"2023","journal-title":"Endokrynol. Pol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/s41591-019-0610-4","article-title":"Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans","volume":"25","author":"Guseh","year":"2019","journal-title":"Nat. Med."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Lei, L., Huan, Y., Liu, Q., Li, C., Cao, H., Ji, W., Gao, X., Fu, Y., Li, P., and Zhang, R. (2022). Morus alba L.(Sangzhi) alkaloids promote insulin secretion, restore diabetic \u03b2-cell function by preventing dedifferentiation and apoptosis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.841981"},{"key":"ref_318","doi-asserted-by":"crossref","unstructured":"Gojani, E.G., Wang, B., Li, D.-P., Kovalchuk, O., and Kovalchuk, I. (2023). Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing \u03b2-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions. Molecules, 28.","DOI":"10.3390\/molecules28227619"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"119312","DOI":"10.1016\/j.lfs.2021.119312","article-title":"Piperine protects against pancreatic \u03b2-cell dysfunction by alleviating macrophage inflammation in obese mice","volume":"274","author":"Yuan","year":"2021","journal-title":"Life Sci."},{"key":"ref_320","doi-asserted-by":"crossref","unstructured":"Gojani, E.G., Wang, B., Li, D.-P., Kovalchuk, O., and Kovalchuk, I. (2024). The Impact of Psilocybin on High Glucose\/Lipid-Induced Changes in INS-1 Cell Viability and Dedifferentiation. Genes, 15.","DOI":"10.3390\/genes15020183"},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Gojani, E.G., Wang, B., Li, D.-P., Kovalchuk, O., and Kovalchuk, I. (2023). Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on \u03b2-Cells Exposed to High Glucose\u2014High Lipids. Preprints, 2023090973.","DOI":"10.20944\/preprints202309.0973.v1"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s13770-022-00435-7","article-title":"Gymnemic Acid Ameliorates Pancreatic \u03b2-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for \u03b2-Cell Regeneration","volume":"19","author":"Kannan","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/2211-5463.13556","article-title":"Beta cell regeneration upon magainin and growth hormone treatment as a possible alternative to insulin therapy","volume":"13","author":"Moosavi","year":"2023","journal-title":"FEBS Open Bio."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"116564","DOI":"10.1016\/j.jep.2023.116564","article-title":"FTZ promotes islet \u03b2-cell regeneration in T1DM mice via the regulation of nuclear proliferation factors","volume":"315","author":"Zhong","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Montoro, J.I., Damas-Fuentes, M., Fern\u00e1ndez-Garc\u00eda, J.C., and Tinahones, F.J. (2022). Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.869951"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41419-022-04517-1","article-title":"Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of \u03b2 cell identity genes","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Pedersen, S.S., Prause, M., Williams, K., Barr\u00e8s, R., and Billestrup, N. (2022). Butyrate inhibits IL-1\u03b2-induced inflammatory gene expression by suppression of NF-\u03baB activity in pancreatic beta cells. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.102312"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"108694","DOI":"10.1016\/j.isci.2023.108694","article-title":"HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes","volume":"27","author":"Vandenbempt","year":"2024","journal-title":"iScience"},{"key":"ref_329","doi-asserted-by":"crossref","unstructured":"Liang, Y., Widjaja, J., Sun, J., Li, M., Qiao, Z., Cao, T., Wang, Y., Zhang, X., Zhang, Z., and Gu, Y. (2023). Bariatric surgery induces pancreatic cell transdifferentiation as indicated by single-cell transcriptomics in Zucker diabetic rats. J. Diabetes.","DOI":"10.1111\/1753-0407.13521"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1089\/scd.2021.0160","article-title":"Navigating the Genomic Landscape of Human Adipose Stem Cell-Derived \u03b2-Cells","volume":"30","author":"Koduru","year":"2021","journal-title":"Stem Cells Dev."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"122579","DOI":"10.1016\/j.lfs.2024.122579","article-title":"Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy","volume":"344","author":"Kamal","year":"2024","journal-title":"Life Sci."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00441-023-03773-7","article-title":"Promoting \u03b2-cells function by the recapitulation of in vivo microenvironmental differentiation signals","volume":"393","author":"Zaeifi","year":"2023","journal-title":"Cell Tissue Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1038\/ncomms10080","article-title":"Human pancreatic beta-like cells converted from fibroblasts","volume":"7","author":"Zhu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_334","doi-asserted-by":"crossref","unstructured":"Wang, L., Liu, T., Liang, R., Wang, G., Liu, Y., Zou, J., Liu, N., Zhang, B., Liu, Y., and Ding, X. (2020). Mesenchymal stem cells ameliorate \u03b2 cell dysfunction of human type 2 diabetic islets by reversing \u03b2 cell dedifferentiation. EBioMedicine, 51.","DOI":"10.1016\/j.ebiom.2019.102615"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s41232-022-00241-7","article-title":"2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: Immunomodulation and beta-cell regeneration","volume":"42","author":"Isildar","year":"2022","journal-title":"Inflamm. Regen."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"bqac193","DOI":"10.1210\/endocr\/bqac193","article-title":"Therapeutic Strategies Targeting Pancreatic Islet \u03b2-Cell Proliferation, Regeneration, and Replacement","volume":"164","author":"Goode","year":"2023","journal-title":"Endocrinology"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"101477","DOI":"10.1016\/j.molmet.2022.101477","article-title":"Emerging diabetes therapies: Bringing back the \u03b2-cells","volume":"60","author":"Basile","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"e157086","DOI":"10.1172\/JCI157086","article-title":"Disrupting the DREAM complex enables proliferation of adult human pancreatic \u03b2 cells","volume":"132","author":"Wang","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_339","doi-asserted-by":"crossref","unstructured":"Barzowska, A., Pucelik, B., Pustelny, K., Matsuda, A., Martyniak, A., St\u0119pniewski, J., Maksymiuk, A., Dawidowski, M., Rothweiler, U., and Dulak, J. (2021). DYRK1A Kinase Inhibitors Promote \u03b2-Cell Survival and Insulin Homeostasis. Cells, 10.","DOI":"10.3390\/cells10092263"},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Guo, Y., Li, L., Yao, Y., and Li, H. (2022). Regeneration of Pancreatic \u03b2-Cells for Diabetes Therapeutics by Natural DYRK1A Inhibitors. Metabolites, 13.","DOI":"10.3390\/metabo13010051"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1021\/acs.jmedchem.7b01847","article-title":"Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors","volume":"61","author":"Czarna","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Ackeifi, C., Wang, P., Karakose, E., Fox, J.E.M., Gonz\u00e1lez, B.J., Liu, H., Wilson, J., Swartz, E., Berrouet, C., and Li, Y. (2020). GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human \u03b2 cell regeneration. Sci. Transl. Med., 12.","DOI":"10.1126\/scitranslmed.aaw9996"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"117374","DOI":"10.1016\/j.jep.2023.117374","article-title":"Pancreatic beta cell regenerative potential of Zanthoxylum chalybeum Engl. Aqueous stem bark extract","volume":"320","author":"Kimani","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.bbrc.2019.03.148","article-title":"Glucagon receptor antagonism increases mouse pancreatic \u03b4-cell mass through cell proliferation and duct-derived neogenesis","volume":"512","author":"Gu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"104567","DOI":"10.1016\/j.isci.2022.104567","article-title":"Pro-\u03b1-cell-derived \u03b2-cells contribute to \u03b2-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice","volume":"25","author":"Cui","year":"2022","journal-title":"iScience"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"e2022142118","DOI":"10.1073\/pnas.2022142118","article-title":"Glucagon blockade restores functional \u03b2-cell mass in type 1 diabetic mice and enhances function of human islets","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"e001025","DOI":"10.1136\/bmjdrc-2019-001025","article-title":"Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes","volume":"8","author":"Lang","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"170349","DOI":"10.1016\/j.peptides.2020.170349","article-title":"Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice","volume":"131","author":"Lang","year":"2020","journal-title":"Peptides"},{"key":"ref_349","first-page":"1","article-title":"A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1","volume":"2019","author":"Zhang","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/7765623","article-title":"Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic \u03b2-Cell Regeneration In Situ in Type 1 Diabetic Mice","volume":"2021","author":"Gu","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"154324","DOI":"10.1016\/j.metabol.2020.154324","article-title":"Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice","volume":"111","author":"Wei","year":"2020","journal-title":"Metabolism"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2337\/db23-0553","article-title":"Gut microbiota\u2013tryptophan metabolism\u2013GLP-1 axis participates in \u03b2-cell regeneration induced by dapagliflozin","volume":"73","author":"Jiang","year":"2024","journal-title":"Diabetes"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s42255-020-0171-3","article-title":"Targeted pharmacological therapy restores \u03b2-cell function for diabetes remission","volume":"2","author":"Sachs","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00592-022-01970-4","article-title":"\u03b3-aminobutyric acid modulates \u03b1-cell hyperplasia but not \u03b2-cell regeneration induced by glucagon receptor antagonism in type 1 diabetic mice","volume":"60","author":"Gu","year":"2022","journal-title":"Acta Diabetol."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1038\/s41598-022-08168-2","article-title":"The effect of spermidine on autoimmunity and beta cell function in NOD mice","volume":"12","author":"Karacay","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"101261","DOI":"10.1016\/j.xcrm.2023.101261","article-title":"Inhibition of polyamine biosynthesis preserves \u03b2 cell function in type 1 diabetes","volume":"4","author":"Sims","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"15587","DOI":"10.1038\/s41598-018-33875-0","article-title":"Inhibition of TBK1\/IKK\u03b5 promotes regeneration of pancreatic \u03b2-cells","volume":"8","author":"Xu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s42255-021-00391-x","article-title":"In vivo screen identifies a SIK inhibitor that induces \u03b2 cell proliferation through a transient UPR","volume":"3","author":"Charbord","year":"2021","journal-title":"Nat. Metab."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/7\/453\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:19:06Z","timestamp":1760109546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/7\/453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":358,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["cimb46070453"],"URL":"https:\/\/doi.org\/10.3390\/cimb46070453","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]}}}