{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:33:55Z","timestamp":1775082835302,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The present investigation aims to examine the role of \u03b1-synuclein seed amplification assays for screening Parkinson\u2019s disease. Parkinson\u2019s disease (PD) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. It is classified as an \u03b1-synucleinopathy related to the role of \u03b1-synuclein aggregates in neuron degeneration. Diagnosis relies on clinical assessment without premortem diagnostic tests or imaging, often resulting in delayed detection and impaired symptom management. In this regard, our study explores a screening technique using an amplification assay to measure \u03b1-synuclein levels in cerebrospinal fluid, which could potentially identify early pathological changes and improve diagnostic accuracy and patient outcomes. While preliminary results are promising, further studies are needed to evaluate this approach\u2019s accuracy and clinical feasibility. A review of numerous trials demonstrates that \u03b1-synuclein seeding amplification assays (SAA) are a highly reliable, sensitive, and specific diagnostic tool for PD. This assay offers a promising opportunity to improve early diagnosis and quantify severity, especially for asymptomatic individuals or those with a family history of PD, allowing for earlier intervention and more effective disease management. In summary, the emerging body of evidence supporting \u03b1-synuclein as a biomarker should allow patients with PD to be detected and treated sooner, enhancing patients\u2019 quality of life and potentially changing the disease trajectory.<\/jats:p>","DOI":"10.3390\/cimb46110757","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T09:36:51Z","timestamp":1731404211000},"page":"12746-12755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parkinson\u2019s Disease: A Narrative of the Evolving Understanding of the Role of \u03b1-Synuclein in Screening"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-0187","authenticated-orcid":false,"given":"Alan D.","family":"Kaye","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"},{"name":"Department of Pharmacology, Toxicology and Neurosciences, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7836-9867","authenticated-orcid":false,"given":"Kassady A.","family":"Perkinson","sequence":"additional","affiliation":[{"name":"Edward Via College of Osteopathic Medicine, Monroe, LA 71203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah J.","family":"Spillers","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis J.","family":"Vega","sequence":"additional","affiliation":[{"name":"Medical City Weatherford, 713 E Anderson St, Weatherford, TX 76086, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2807-786X","authenticated-orcid":false,"given":"Caylin J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan M.","family":"Downs","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1084-529X","authenticated-orcid":false,"given":"Melissa M.","family":"Sheth","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"David W.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Ahmadzadeh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibin","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4545-4523","authenticated-orcid":false,"given":"Sahar","family":"Shekoohi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson\u2019s Disease and Parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. 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