{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:30:53Z","timestamp":1790973053790,"version":"4.1.0"},"reference-count":216,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Misshapen\/NIKs-related kinase (MINK) 1 belongs to the mammalian germinal center kinase (GCK) family. It contains the N-terminal, conserved kinase domain, a coiled-coil region, a proline-rich region, and a GCK, C-terminal domain with the Citron-NIK-Homology (CNH) domain. The kinase is an essential component of cellular signaling pathways, which include Wnt signaling, JNK signaling, pathways engaging Ras proteins, the Hippo pathway, and STRIPAK complexes. It thus contributes to regulating the cell cycle, apoptosis, cytoskeleton organization, cell migration, embryogenesis, or tissue homeostasis. MINK1 plays an important role in immunological responses, inhibiting Th17 and Th1 cell differentiation and regulating NLRP3 inflammasome function. It may be considered a link between ROS and the immunological system, and a potential antiviral target for human enteroviruses. The kinase has been implicated in the pathogenesis of sepsis, rheumatoid arthritis, asthma, SLE, and more. It is also involved in tumorigenesis and drug resistance in cancer. Silencing MINK1 reduces cancer cell migration, suggesting potential for new therapeutic approaches. Targeting MINK1 could be a promising treatment strategy for patients insensitive to current chemotherapies, and could improve their prognosis. Moreover, MINK1 plays an important role in the nervous system and the cardiovascular system development and function. The modulation of MINK1 activity could influence the course of neurodegenerative diseases, including Alzheimer\u2019s disease. Further exploration of the activity of the kinase could also help in gaining more insight into factors involved in thrombosis or congenital heart disease. This review aims to summarize the current knowledge on MINK1, highlight its therapeutic and prognostic potential, and encourage more studies in this area.<\/jats:p>","DOI":"10.3390\/cimb46120826","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T09:30:18Z","timestamp":1733391018000},"page":"13811-13845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Potential of Misshapen\/NIKs-Related Kinase (MINK) 1\u2014A Many-Sided Element of Cell Physiology and Pathology"],"prefix":"10.3390","volume":"46","author":[{"given":"Anna","family":"Kot","sequence":"first","affiliation":[{"name":"Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Koszewska","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u0142a\u017cej","family":"Ochman","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"\u015awi\u0119tochowska","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 Jordana, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, Z., Shang, Y., Yuan, Y., He, Y., Wasti, B., Duan, W., Ouyang, R., Jia, J., Xiao, B., and Zhang, D. (2022). MBD2 Mediates Th17 Cell Differentiation by Regulating MINK1 in Th17-Dominant Asthma. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.959059"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/ng.3970","article-title":"Contribution of Rare Inherited and de Novo Variants in 2,871 Congenital Heart Disease Probands","volume":"49","author":"Jin","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1523\/JNEUROSCI.0905-17.2017","article-title":"The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons","volume":"37","author":"Larhammar","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molcel.2005.10.038","article-title":"Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells","volume":"20","author":"Nicke","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_5","unstructured":"Murphy, M., Brown, G., Wallin, C., Tatusova, T., Pruitt, K., and Maglott, D. (2006). Gene Help: Integrated Access to Genes of Genomes in the Reference Sequence Collection. Gene Help [Internet], National Center for Biotechnology Information (US)."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Singh, P.P., Arora, J., and Isambert, H. (2015). Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes. PLoS Comput. Biol., 11.","DOI":"10.1371\/journal.pcbi.1004394"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-5793(00)01247-3","article-title":"Molecular Cloning of MINK, a Novel Member of Mammalian GCK Family Kinases, Which Is up-Regulated during Postnatal Mouse Cerebral Development","volume":"469","author":"Dan","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tim.2011.04.006","article-title":"Ste20-Related Kinases: Effectors of Signaling and Morphogenesis in Fungi","volume":"19","author":"Boyce","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/MCB.06320-11","article-title":"Mink1 Regulates \u03b2-Catenin-Independent Wnt Signaling via Prickle Phosphorylation","volume":"32","author":"Daulat","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/0929867043455873","article-title":"Computational and Experimental Studies on Human Misshapen\/NIK-Related Kinase MINK-1","volume":"11","author":"Qu","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0960-9822(02)01184-3","article-title":"14-3-3 Regulates Actin Dynamics by Stabilizing Phosphorylated Cofilin","volume":"12","author":"Gohla","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/excr.2001.5376","article-title":"Functional Conservation of 14-3-3 Isoforms in Inhibiting Bad-Induced Apoptosis","volume":"271","author":"Subramanian","year":"2001","journal-title":"Exp. Cell Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-1119(01)00521-2","article-title":"Isolation of hNap1BP Which Interacts with Human Nap1 (NCKAP1) Whose Expression Is down-Regulated in Alzheimer\u2019s Disease","volume":"271","author":"Yamamoto","year":"2001","journal-title":"Gene"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1074\/jbc.274.9.5762","article-title":"Cell Adhesion Regulates the Interaction between the Docking Protein p130Cas and the 14-3-3 Proteins","volume":"274","author":"Dolfi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2008.10.038","article-title":"MINK Is a Rap2 Effector for Phosphorylation of the Postsynaptic Scaffold Protein TANC1","volume":"377","author":"Nonaka","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mikryukov, A., and Moss, T. (2012). Agonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043330"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.21147\/j.issn.1000-9604.2023.04.04","article-title":"Striatins and STRIPAK Complex Partners in Clinical Outcomes of Patients with Breast Cancer and Responses to Drug Treatment","volume":"35","author":"Li","year":"2023","journal-title":"Chin. J. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1002\/cam4.3890","article-title":"Normal Tissue Adjacent to Tumor Expression Profile Analysis Developed and Validated a Prognostic Model Based on Hippo-related Genes in Hepatocellular Carcinoma","volume":"10","author":"Pan","year":"2021","journal-title":"Cancer Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, Z.-L., Zhao, L., Chai, L., Zhou, S.-H., Wang, F., Wei, Y., Xu, Y.-P., and Zhao, P. (2017). Seven LncRNA-mRNA Based Risk Score Predicts the Survival of Head and Neck Squamous Cell Carcinoma. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-00252-2"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"54387","DOI":"10.1074\/jbc.M404497200","article-title":"Identification and Functional Characterization of a Novel Human Misshapen\/Nck Interacting Kinase-Related Kinase, hMINK\u03b2","volume":"279","author":"Hu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1091\/mbc.8.4.647","article-title":"Sec3p Is Involved in Secretion and Morphogenesis in Saccharomyces Cerevisiae","volume":"8","author":"Finger","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1006\/jmbi.1998.2115","article-title":"An Extracellular \u03b2-Propeller Module Predicted in Lipoprotein and Scavenger Receptors, Tyrosine Kinases, Epidermal Growth Factor Precursor, and Extracellular Matrix Components","volume":"283","author":"Springer","year":"1998","journal-title":"J. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14786","DOI":"10.1523\/JNEUROSCI.4124-10.2010","article-title":"MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function","volume":"30","author":"Hussain","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1158\/1541-7786.MCR-18-1154","article-title":"Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and \u03b2-Catenin\u2013Independent Targets by Proteomics","volume":"17","author":"Popow","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1038\/sj.emboj.7601781","article-title":"XRab40 and XCullin5 Form a Ubiquitin Ligase Complex Essential for the Noncanonical Wnt Pathway","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1083\/jcb.135.5.1277","article-title":"Roles for Racl and Cdc42 in Planar Polarization and Hair Outgrowth in the Wing of Drosophila","volume":"135","author":"Eaton","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0960-9822(03)00374-9","article-title":"Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse","volume":"13","author":"Curtin","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1242\/jcs.00973","article-title":"Planar Polarity from Flies to Vertebrates","volume":"117","author":"Fanto","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)80046-X","article-title":"Flamingo, a Seven-Pass Transmembrane Cadherin, Regulates Planar Cell Polarity under the Control of Frizzled","volume":"98","author":"Usui","year":"1999","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0012-1606(87)90061-3","article-title":"Multiple Functions of Segment Polarity Genes in Drosophila","volume":"119","author":"Perrimon","year":"1987","journal-title":"Dev. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1534-5807(01)00010-7","article-title":"The Ankyrin Repeat Protein Diego Mediates Frizzled-Dependent Planar Polarization","volume":"1","author":"Feiguin","year":"2001","journal-title":"Dev. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1101\/gad.13.17.2315","article-title":"The Balance between Isoforms of the Prickle LIM Domain Protein Is Critical for Planar Polarity in Drosophila Imaginal Discs","volume":"13","author":"Gubb","year":"1999","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/genetics\/150.1.199","article-title":"Van Gogh: A New Drosophila Tissue Polarity Gene","volume":"150","author":"Taylor","year":"1998","journal-title":"Genetics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature07564","article-title":"WNT11 Acts as a Directional Cue to Organize the Elongation of Early Muscle Fibres","volume":"457","author":"Gros","year":"2009","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/embo-reports\/kvf008","article-title":"JNK Functions in the Non-canonical Wnt Pathway to Regulate Convergent Extension Movements in Vertebrates","volume":"3","author":"Yamanaka","year":"2002","journal-title":"EMBO Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.devcel.2017.02.010","article-title":"A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking","volume":"40","author":"Minegishi","year":"2017","journal-title":"Dev. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15707","DOI":"10.1074\/jbc.M115.639609","article-title":"Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/MCB.23.1.131-139.2003","article-title":"The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a\/Ca2+ Pathway To Antagonize Wnt\/\u03b2-Catenin Signaling","volume":"23","author":"Ishitani","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.18632\/oncotarget.3518","article-title":"WNT5A Promotes Stemness Characteristics in Nasopharyngeal Carcinoma Cells Leading to Metastasis and Tumorigenesis","volume":"6","author":"Qin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1093\/emboj\/cdg424","article-title":"Prickle and Strabismus Form a Functional Complex to Generate a Correct Axis during Planar Cell Polarity Signaling","volume":"22","author":"Jenny","year":"2003","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1158\/0008-5472.CAN-10-0306","article-title":"Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth","volume":"70","author":"Shitashige","year":"2010","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1038\/emboj.2009.285","article-title":"The Kinase TNIK Is an Essential Activator of Wnt Target Genes","volume":"28","author":"Mahmoudi","year":"2009","journal-title":"EMBO J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.devcel.2016.04.011","article-title":"PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2","volume":"37","author":"Daulat","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"jcs259347","DOI":"10.1242\/jcs.259347","article-title":"The Serine\/Threonine Kinase MINK1 Directly Regulates the Function of Promigratory Proteins","volume":"135","author":"Daulat","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.devcel.2006.05.012","article-title":"CLASPs Attach Microtubule Plus Ends to the Cell Cortex through a Complex with LL5\u03b2","volume":"11","author":"Lansbergen","year":"2006","journal-title":"Dev. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16155","DOI":"10.1074\/jbc.M109.081901","article-title":"LL5\u03b2 Directs the Translocation of Filamin A and SHIP2 to Sites of Phosphatidylinositol 3,4,5-Triphosphate (PtdIns(3,4,5)P3) Accumulation, and PtdIns(3,4,5)P3 Localization Is Mutually Modified by Co-Recruited SHIP2","volume":"285","author":"Takabayashi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1158\/1078-0432.CCR-07-1644","article-title":"WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt\/\u03b2-Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer","volume":"14","author":"Ying","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1535-6108(03)00268-X","article-title":"Wnt5a Inhibits B Cell Proliferation and Functions as a Tumor Suppressor in Hematopoietic Tissue","volume":"4","author":"Liang","year":"2003","journal-title":"Cancer Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1515\/hsz-2016-0276","article-title":"The Small GTPases Ras and Rheb Studied by Multidimensional NMR Spectroscopy: Structure and Function","volume":"398","author":"Potheraveedu","year":"2017","journal-title":"Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1152\/physiolgenomics.00210.2005","article-title":"Comparative and Evolutionary Analysis of Genes Encoding Small GTPases and Their Activating Proteins in Eukaryotic Genomes","volume":"24","author":"Jiang","year":"2006","journal-title":"Physiol. Genomics"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP Kinase Kinase Is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1101\/gad.191101","article-title":"Analysis of the Transcriptional Program Induced by Raf in Epithelial Cells","volume":"15","author":"Schulze","year":"2001","journal-title":"Genes Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/MCB.21.7.2324-2336.2001","article-title":"Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals","volume":"21","author":"Lorenz","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1016\/S0021-9258(17)37478-1","article-title":"Mitogen-Activated Protein Kinase\/Extracellular Signal-Regulated Protein Kinase Activation by Oncogenes, Serum, and 12-O-Tetradecanoylphorbol-13-Acetate Requires Raf and Is Necessary for Transformation","volume":"269","author":"Troppmair","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2217\/fon.14.279","article-title":"Prognostic Role of KRAS, NRAS, BRAF and PIK3CA Mutations in Advanced Colorectal Cancer","volume":"11","author":"Foltran","year":"2015","journal-title":"Future Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1002\/cncr.26724","article-title":"NRAS Mutation Status Is an Independent Prognostic Factor in Metastatic Melanoma","volume":"118","author":"Jakob","year":"2012","journal-title":"Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-021-01127-w","article-title":"Emerging Strategies to Target RAS Signaling in Human Cancer Therapy","volume":"14","author":"Chen","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1158\/0008-5472.CAN-19-3682","article-title":"The Frequency of Ras Mutations in Cancer","volume":"80","author":"Prior","year":"2020","journal-title":"Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1128\/MCB.20.16.6074-6083.2000","article-title":"Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade","volume":"20","author":"Ohba","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1460-9568.2005.03856.x","article-title":"A Novel Scaffold Protein, TANC, Possibly a Rat Homolog of Drosophila Rolling Pebbles (Rols), Forms a Multiprotein Complex with Various Postsynaptic Density Proteins","volume":"21","author":"Suzuki","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/j.1460-2075.1996.tb00636.x","article-title":"Selective Interaction of JNK Protein Kinase Isoforms with Transcription Factors","volume":"15","author":"Gupta","year":"1996","journal-title":"EMBO J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0896-6273(00)80727-8","article-title":"The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development","volume":"22","author":"Kuan","year":"1999","journal-title":"Neuron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.4260","article-title":"JNK1 Negatively Controls Antifungal Innate Immunity by Suppressing CD23 Expression","volume":"23","author":"Zhao","year":"2017","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1534-5807(03)00094-7","article-title":"JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins","volume":"4","author":"Chang","year":"2003","journal-title":"Dev. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pneurobio.2006.08.002","article-title":"The Bright Side of JNKs\u2014Multitalented Mediators in Neuronal Sprouting, Brain Development and Nerve Fiber Regeneration","volume":"80","author":"Waetzig","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1460-9568.2005.03857.x","article-title":"Specific Pathophysiological Functions of JNK Isoforms in the Brain","volume":"21","author":"Brecht","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/153331750201700209","article-title":"The JNK\/c-Jun Cascade and Alzheimer\u2019s Disease","volume":"17","author":"Okazawa","year":"2002","journal-title":"Am. J. Alzheimers Dis. Dementiasr"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3233\/JAD-2011-110320","article-title":"JNK Plays a Key Role in Tau Hyperphosphorylation in Alzheimer\u2019s Disease Models","volume":"26","author":"Ploia","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cellimm.2014.05.001","article-title":"A Comparative Study of the Effects of Inhibitory Cytokines on Human Natural Killer Cells and the Mechanistic Features of Transforming Growth Factor-Beta","volume":"290","author":"Lee","year":"2014","journal-title":"Cell. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.20130990","article-title":"Co-Inhibition of NF-\u03baB and JNK Is Synergistic in TNF-Expressing Human AML","volume":"211","author":"Volk","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.cellsig.2012.06.014","article-title":"Fullerene Derivative Prevents Cellular Transformation Induced by JAK2 V617F Mutant through Inhibiting C-Jun N-Terminal Kinase Pathway","volume":"24","author":"Nagata","year":"2012","journal-title":"Cell. Signal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/ijms15010545","article-title":"Syk\/JNK\/AP-1 Signaling Pathway Mediates Interleukin-6-Promoted Cell Migration in Oral Squamous Cell Carcinoma","volume":"15","author":"Chuang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1101\/gad.12.15.2371","article-title":"The Drosophila Ste20-Related Kinase Misshapen Is Required for Embryonic Dorsal Closure and Acts through a JNK MAPK Module on an Evolutionarily Conserved Signaling Pathway","volume":"12","author":"Su","year":"1998","journal-title":"Genes Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0006-291X(02)02909-1","article-title":"Identification of Residues Which Regulate Activity of the STE20-Related Kinase hMINK","volume":"300","author":"Lim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1083\/jcb.201103153","article-title":"DLK Induces Developmental Neuronal Degeneration via Selective Regulation of Proapoptotic JNK Activity","volume":"194","author":"Wang","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/tox.23361","article-title":"LncRNA SNHG14 Contributes to Proinflammatory Cytokine Production in Rheumatoid Arthritis via the Regulation of the miR-17-5p\/MINK1-JNK Pathway","volume":"36","author":"Zhang","year":"2021","journal-title":"Environ. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1128\/MCB.26.1.77-87.2006","article-title":"Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65","volume":"26","author":"Boone","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"21064","DOI":"10.1073\/pnas.1012759107","article-title":"Hippo Signaling Regulates Drosophila Intestine Stem Cell Proliferation through Multiple Pathways","volume":"107","author":"Ren","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ceb.2012.12.006","article-title":"The Hippo Superhighway: Signaling Crossroads Converging on the Hippo\/Yap Pathway in Stem Cells and Development","volume":"25","author":"Barry","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"Hippo Encodes a Ste-20 Family Protein Kinase That Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with Salvador and Warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb1050","article-title":"Hippo Promotes Proliferation Arrest and Apoptosis in the Salvador\/Warts Pathway","volume":"5","author":"Udan","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(03)00557-9","article-title":"The Drosophila Mst Ortholog, Hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis","volume":"114","author":"Harvey","year":"2003","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/ncb1051","article-title":"The Salvador Partner Hippo Promotes Apoptosis and Cell-Cycle Exit in Drosophila","volume":"5","author":"Pantalacci","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A Mechanical Checkpoint Controls Multicellular Growth through YAP\/TAZ Regulation by Actin-Processing Factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncb3113","article-title":"AMPK Modulates Hippo Pathway Activity to Regulate Energy Homeostasis","volume":"17","author":"Wang","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1101\/gad.173435.111","article-title":"Cell Detachment Activates the Hippo Pathway via Cytoskeleton Reorganization to Induce Anoikis","volume":"26","author":"Zhao","year":"2012","journal-title":"Genes Dev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncb3111","article-title":"Cellular Energy Stress Induces AMPK-Mediated Regulation of YAP and the Hippo Pathway","volume":"17","author":"Mo","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.celrep.2014.09.036","article-title":"Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein","volume":"9","author":"DeRan","year":"2014","journal-title":"Cell Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1101\/gad.219402.113","article-title":"Protein Kinase A Activates the Hippo Pathway to Modulate Cell Proliferation and Differentiation","volume":"27","author":"Yu","year":"2013","journal-title":"Genes Dev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","article-title":"The Hippo Pathway: Regulators and Regulations","volume":"27","author":"Yu","year":"2013","journal-title":"Genes Dev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1242\/jcs.140103","article-title":"The Hippo-YAP Signaling Pathway and Contact Inhibition of Growth","volume":"127","author":"Gumbiner","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The Hippo Pathway and Human Cancer","volume":"13","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1038\/ncomms9357","article-title":"MAP4K Family Kinases Act in Parallel to MST1\/2 to Activate LATS1\/2 in the Hippo Pathway","volume":"6","author":"Meng","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-018-0444-0","article-title":"RAP2 Mediates Mechanoresponses of the Hippo Pathway","volume":"560","author":"Meng","year":"2018","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"25019","DOI":"10.1074\/jbc.M112.372342","article-title":"Misshapen-like Kinase 1 (MINK1) Is a Novel Component of Striatin-Interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis","volume":"287","author":"Hyodo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1471-4159.2008.05448.x","article-title":"Distribution of Zinedin in the Rat Brain","volume":"106","author":"Benoist","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jphysparis.2005.12.006","article-title":"The Striatin Family: A New Signaling Platform in Dendritic Spines","volume":"99","author":"Benoist","year":"2006","journal-title":"J. Physiol.-Paris"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1074\/jbc.275.8.5257","article-title":"WD40 Repeat Proteins Striatin and S\/G2 Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-Binding Proteins That Associate with Protein Phosphatase 2A","volume":"275","author":"Moreno","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-Interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"H1810","DOI":"10.1152\/ajpheart.01015.2004","article-title":"Molecular Properties of Cardiac Tail-Anchored Membrane Protein SLMAP Are Consistent with Structural Role in Arrangement of Excitation-Contraction Coupling Apparatus","volume":"288","author":"Guzzo","year":"2005","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00439-010-0855-y","article-title":"Genome-Wide Association Identifies a Deletion in the 3\u2032 Untranslated Region of Striatin in a Canine Model of Arrhythmogenic Right Ventricular Cardiomyopathy","volume":"128","author":"Meurs","year":"2010","journal-title":"Hum. Genet."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng.716","article-title":"Common Variants in 22 Loci Are Associated with QRS Duration and Cardiac Ventricular Conduction","volume":"42","author":"Sotoodehnia","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"H206","DOI":"10.1152\/ajpheart.00037.2005","article-title":"Endothelial Dysfunction in Type 2 Diabetes Correlates with Deregulated Expression of the Tail-Anchored Membrane Protein SLMAP","volume":"289","author":"Ding","year":"2005","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s00125-012-2511-7","article-title":"Serine\/Threonine Protein Kinase 25 (STK25): A Novel Negative Regulator of Lipid and Glucose Metabolism in Rodent and Human Skeletal Muscle","volume":"55","author":"Nerstedt","year":"2012","journal-title":"Diabetologia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/geno.2001.6651","article-title":"Identification of the Human Cortactin-Binding Protein-2 Gene from the Autism Candidate Region at 7q31","volume":"78","author":"Cheung","year":"2001","journal-title":"Genomics"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2012.04.009","article-title":"De Novo Gene Disruptions in Children on the Autistic Spectrum","volume":"74","author":"Iossifov","year":"2012","journal-title":"Neuron"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1136\/mp.54.5.324","article-title":"Differentially Expressed Genes in Association with in Vitro Invasiveness of Human Epithelioid Sarcoma","volume":"54","author":"Weber","year":"2001","journal-title":"Mol. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/gcc.20023","article-title":"Identification of a Novel Gene, FGFR1OP2, Fused to FGFR1 in 8p11 Myeloproliferative Syndrome","volume":"40","author":"Grand","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1086\/426952","article-title":"Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations","volume":"76","author":"Bergametti","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/hmg\/ddn430","article-title":"Biallelic Somatic and Germline Mutations in Cerebral Cavernous Malformations (CCMs): Evidence for a Two-Hit Mechanism of CCM Pathogenesis","volume":"18","author":"Akers","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK Complexes: Structure, Biological Function, and Involvement in Human Diseases","volume":"47","author":"Hwang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1083\/jcb.135.6.1701","article-title":"Antibody Microinjection Reveals an Essential Role for Human Polo-like Kinase 1 (Plkl) in the Functional Maturation of Mitotic Centrosomes","volume":"135","author":"Lane","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/35065617","article-title":"Polo-like Kinase 1 Phosphorylates Cyclin B1 and Targets It to the Nucleus during Prophase","volume":"410","author":"Taniguchi","year":"2001","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(88)90175-4","article-title":"Activation of Cdc2 Protein Kinase during Mitosis in Human Cells: Cell Cycle-Dependent Phosphorylation and Subunit Rearrangement","volume":"54","author":"Draetta","year":"1988","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Gordon, J., Hwang, J., Carrier, K.J., Jones, C.A., Kern, Q.L., Moreno, C.S., Karas, R.H., and Pallas, D.C. (2011). Protein Phosphatase 2a (PP2A) Binds within the Oligomerization Domain of Striatin and Regulates the Phosphorylation and Activation of the Mammalian Ste20-Like Kinase Mst3. BMC Biochem., 12.","DOI":"10.1186\/1471-2091-12-54"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2013.09.005","article-title":"The BEG (PP2A-B55\/ENSA\/Greatwall) Pathway Ensures Cytokinesis Follows Chromosome Separation","volume":"52","author":"Cundell","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.201606033","article-title":"A PP2A-B55 Recognition Signal Controls Substrate Dephosphorylation Kinetics during Mitotic Exit","volume":"214","author":"Cundell","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ncb2092","article-title":"Live-Cell Imaging RNAi Screen Identifies PP2A\u2013B55\u03b1 and Importin-\u03921 as Key Mitotic Exit Regulators in Human Cells","volume":"12","author":"Schmitz","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-020-17089-5","article-title":"Mapping Effector Genes at Lupus GWAS Loci Using Promoter Capture-C in Follicular Helper T Cells","volume":"11","author":"Su","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1038\/s41423-021-00761-1","article-title":"Priming of NLRP3 Inflammasome Activation by Msn Kinase MINK1 in Macrophages","volume":"18","author":"Zhu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.20161120","article-title":"Suppression of Th17 Cell Differentiation by Misshapen\/NIK-Related Kinase MINK1","volume":"214","author":"Fu","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 Drives a Pathogenic T Cell Population That Induces Autoimmune Inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/08916934.2019.1693545","article-title":"Th1, Th2, and Th17 Cytokines in Systemic Lupus Erythematosus","volume":"53","author":"Wong","year":"2020","journal-title":"Autoimmunity"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2010.04.010","article-title":"Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease","volume":"32","author":"Reynolds","year":"2010","journal-title":"Immunity"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A Distinct Lineage of CD4 T Cells Regulates Tissue Inflammation by Producing Interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1067\/mai.2003.1557","article-title":"Airway Remodeling-Associated Mediators in Moderate to Severe Asthma: Effect of Steroids on TGF-\u03b2, IL-11, IL-17, and Type I and Type III Collagen Expression","volume":"111","author":"Chakir","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cyto.2014.12.027","article-title":"Th1\/Th2\/Th17\/Treg Cytokine Imbalance in Systemic Lupus Erythematosus (SLE) Patients: Correlation with Disease Activity","volume":"72","author":"Talaat","year":"2015","journal-title":"Cytokine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.4049\/jimmunol.1200528","article-title":"Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1\u2013Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling","volume":"189","author":"Zhi","year":"2012","journal-title":"J. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"11127","DOI":"10.1073\/pnas.1104128108","article-title":"Smad Inhibition by the Ste20 Kinase Misshapen","volume":"108","author":"Kaneko","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI76012","article-title":"Metabolic Programming and PDHK1 Control CD4+ T Cell Subsets and Inflammation","volume":"125","author":"Gerriets","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-Specific Role in the Inflammatory Response","volume":"55","author":"Kummer","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/ni.2919","article-title":"The NLRP3 Inflammasome Is Released as a Particulate Danger Signal That Amplifies the Inflammatory Response","volume":"15","author":"Gomez","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1186\/cc9974","article-title":"Inhibition of Caspase-1 Activation in Gram-Negative Sepsis and Experimental Endotoxemia","volume":"15","author":"Mouktaroudi","year":"2011","journal-title":"Crit. Care"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-Associated Uric Acid Crystals Activate the NALP3 Inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty Acid\u2013Induced NLRP3-ASC Inflammasome Activation Interferes with Insulin Signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"National Asthma Education and Prevention Program (2007). Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma\u2013Summary Report 2007. J. Allergy Clin. Immunol., 120, S94\u2013S138.","DOI":"10.1016\/j.jaci.2007.09.029"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1183\/13993003.00779-2015","article-title":"Clinical and Inflammatory Characteristics of the European U-BIOPRED Adult Severe Asthma Cohort","volume":"46","author":"Shaw","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1164\/rccm.201512-2452OC","article-title":"A Transcriptome-Driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED","volume":"195","author":"Kuo","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2019.03.027","article-title":"IL-17\u2013High Asthma with Features of a Psoriasis Immunophenotype","volume":"144","author":"Schofield","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jaut.2014.05.006","article-title":"MBD2 Regulates TH17 Differentiation and Experimental Autoimmune Encephalomyelitis by Controlling the Homeostasis of T-Bet\/Hlx Axis","volume":"53","author":"Zhong","year":"2014","journal-title":"J. Autoimmun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00281-017-0627-z","article-title":"The Role of Autoantibodies in the Pathophysiology of Rheumatoid Arthritis","volume":"39","author":"Derksen","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"102400","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The Etiology of Rheumatoid Arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41417-018-0067-5","article-title":"LncRNA SNHG14 Promotes Inflammatory Response Induced by Cerebral Ischemia\/Reperfusion Injury through Regulating miR-136-5p\/ROCK1","volume":"26","author":"Zhong","year":"2019","journal-title":"Cancer Gene Ther."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New Insights into the Immunopathogenesis of Systemic Lupus Erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/art.21955","article-title":"Mortality in Systemic Lupus Erythematosus","volume":"54","author":"Bernatsky","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Leong, S.Y., Ong, B.K.T., and Chu, J.J.H. (2015). The Role of Misshapen NCK-Related Kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004686"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Jiang, L., Jiang, H., Tian, X., Xia, X., and Huang, T. (2021). Epidemiological Characteristics of Hand, Foot, and Mouth Disease in Yunnan Province, China, 2008\u20132019. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06462-4"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1017\/S095026881500028X","article-title":"Case-Fatality of Hand, Foot and Mouth Disease Associated with EV71: A Systematic Review and Meta-Analysis","volume":"143","author":"Zhao","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1128\/JVI.02476-08","article-title":"hnRNP A1 Interacts with the 5\u2032 Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication","volume":"83","author":"Lin","year":"2009","journal-title":"J. Virol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0042-6822(03)00544-0","article-title":"Enterovirus 71 Contains a Type I IRES Element That Functions When Eukaryotic Initiation Factor eIF4G Is Cleaved","volume":"315","author":"Thompson","year":"2003","journal-title":"Virology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.cdd.4401642","article-title":"Internal Ribosome Entry Segment-Mediated Translation during Apoptosis: The Role of IRES-Trans-Acting Factors","volume":"12","author":"Spriggs","year":"2005","journal-title":"Cell Death Differ."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Li, A.X., Martin, T.A., Lane, J., and Jiang, W.G. (2023). Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review). Cancers, 16.","DOI":"10.3390\/cancers16010076"},{"key":"ref_160","first-page":"3862","article-title":"Liprin-\u03b11, ERC1 and LL5 Identify a Polarized, Dynamic Compartment Implicated in Cell Migration","volume":"127","author":"Astro","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_161","first-page":"3115","article-title":"Prickle1 Promotes Focal Adhesion Disassembly in Cooperation with CLASP-LL5\u03b2 Complex in Migrating Cells","volume":"129","author":"Lim","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1038\/s41388-022-02475-8","article-title":"CRISPR-Based Kinome-Screening Revealed MINK1 as a Druggable Player to Rewire 5FU-Resistance in OSCC through AKT\/MDM2\/P53 Axis","volume":"41","author":"Mohanty","year":"2022","journal-title":"Oncogene"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2106196","DOI":"10.1002\/smll.202106196","article-title":"High-Throughput DNA Tensioner Platform for Interrogating Mechanical Heterogeneity of Single Living Cells","volume":"18","author":"Hang","year":"2022","journal-title":"Small"},{"key":"ref_164","first-page":"427","article-title":"FLT3 Inhibitors in the Treatment of Acute Myeloid Leukemia: Current Status and Future Perspectives","volume":"111","year":"2020","journal-title":"Minerva Med."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Stamos, J.L., and Weis, W.I. (2013). The \u03b2-Catenin Destruction Complex. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a007898"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.3390\/cimb44070206","article-title":"Using AI-Based Evolutionary Algorithms to Elucidate Adult Brain Tumor (Glioma) Etiology Associated with IDH1 for Therapeutic Target Identification","volume":"44","author":"McInerney","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.celrep.2017.05.014","article-title":"Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation","volume":"19","author":"Calvert","year":"2017","journal-title":"Cell Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The Incidence of Congenital Heart Disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1651-2227.2007.00381.x","article-title":"Congenital Heart Defects\u2014Chromosomal Anomalies, Syndromes and Extracardiac Malformations","volume":"96","author":"Meberg","year":"2007","journal-title":"Acta Paediatr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0735-1097(89)90122-8","article-title":"Congenital Cardiovascular Malformations: Questions on Inheritance","volume":"14","author":"Ferencz","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ydbio.2022.11.010","article-title":"Mink1 Regulates Spemann Organizer Cell Fate in the Xenopus Gastrula via Hmga2","volume":"495","author":"Colleluori","year":"2023","journal-title":"Dev. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ydbio.2006.09.039","article-title":"The Left\u2013Right Axis Is Regulated by the Interplay of Coco, Xnr1 and Derri\u00e8re in Xenopus Embryos","volume":"303","author":"Vonica","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(94)90069-8","article-title":"Overexpression of Cadherins and Underexpression of B-Catenin Inhibit Dorsal Mesoderm Induction in Early Xenopus Embryos","volume":"79","author":"Heasman","year":"1994","journal-title":"Cell"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Vignali, R., and Marracci, S. (2020). HMGA Genes and Proteins in Development and Evolution. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020654"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/ncb1719","article-title":"A Crucial Role of a High Mobility Group Protein HMGA2 in Cardiogenesis","volume":"10","author":"Monzen","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/bdr2.2012","article-title":"Malarial PI4K Inhibitor Induced Diaphragmatic Hernias in Rat: Potential Link with Mammalian Kinase Inhibition","volume":"114","author":"Donini","year":"2022","journal-title":"Birth Defects Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/blood-2015-07-659185","article-title":"Misshapen\/NIK-Related Kinase (MINK1) Is Involved in Platelet Function, Hemostasis, and Thrombus Formation","volume":"127","author":"Yue","year":"2016","journal-title":"Blood"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"R454","DOI":"10.1152\/ajpregu.1982.243.3.R454","article-title":"Comparative Study of Platelet Dense Granule Constituents","volume":"243","author":"Meyers","year":"1982","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/jth.12138","article-title":"Munc13-4 Is Critical for Thrombosis through Regulating Release of ADP from Platelets","volume":"11","author":"Savage","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood-2008-05-155978","article-title":"Two Distinct Roles of Mitogen-Activated Protein Kinases in Platelets and a Novel Rac1-MAPK\u2013Dependent Integrin Outside-in Retractile Signaling Pathway","volume":"113","author":"Flevaris","year":"2009","journal-title":"Blood"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1182\/blood-2009-07-233932","article-title":"Platelet JNK1 Is Involved in Secretion and Thrombus Formation","volume":"115","author":"Adam","year":"2010","journal-title":"Blood"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1182\/blood-2010-12-323204","article-title":"An Important Role for Akt3 in Platelet Activation and Thrombosis","volume":"118","author":"Hay","year":"2011","journal-title":"Blood"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1586\/ehm.09.75","article-title":"Akt Signaling in Platelets and Thrombosis","volume":"3","author":"Woulfe","year":"2010","journal-title":"Expert Rev. Hematol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"21003","DOI":"10.1074\/jbc.M400103200","article-title":"Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry","volume":"279","author":"Peng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2005.04.037","article-title":"Rap2-JNK Removes Synaptic AMPA Receptors during Depotentiation","volume":"46","author":"Zhu","year":"2005","journal-title":"Neuron"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/08039480902767286","article-title":"Is Schizophrenia a Neurodegenerative Disorder?","volume":"63","author":"Rund","year":"2009","journal-title":"Nord. J. Psychiatry"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/35088558","article-title":"Monogenic Causes of X-Linked Mental Retardation","volume":"2","author":"Chelly","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neurobiolaging.2003.09.001","article-title":"Synaptic Slaughter in Alzheimer\u2019s Disease","volume":"24","author":"Coleman","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1083\/jcb.200511055","article-title":"JNK1 Phosphorylation of SCG10 Determines Microtubule Dynamics and Axodendritic Length","volume":"173","author":"Tararuk","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1128\/MCB.00713-12","article-title":"C-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells","volume":"32","author":"Padzik","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_191","unstructured":"Georges, J., Miller, O., and Bintener, C. (2024, November 28). Estimating the Prevalence of Dementia in Europe. Available online: https:\/\/www.researchgate.net\/publication\/339401240_Estimating_the_prevalence_of_dementia_in_Europe."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical Diagnosis of Alzheimer\u2019s Disease: Report of the NINCDS-ADRDA Work Group under the Auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a Biological Definition of Alzheimer\u2019s Disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The Diagnosis of Dementia Due to Alzheimer\u2019s Disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association Workgroups on Diagnostic Guidelines for Alzheimer\u2019s Disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/pmic.201400189","article-title":"Quantitative Phosphoproteomics of Alzheimer\u2019s Disease Reveals Cross-talk between Kinases and Small Heat Shock Proteins","volume":"15","author":"Dammer","year":"2015","journal-title":"Proteomics"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00401-018-1928-6","article-title":"Dissecting the Genetic Relationship between Cardiovascular Risk Factors and Alzheimer\u2019s Disease","volume":"137","author":"Broce","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"299.e13","DOI":"10.1016\/j.neurobiolaging.2020.11.009","article-title":"Genetic Variants in Glutamate-, A\u03b2-, and Tau-Related Pathways Determine Polygenic Risk for Alzheimer\u2019s Disease","volume":"101","author":"Lawingco","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrrheum.2016.219","article-title":"The Changing Role of TGF\u03b2 in Healthy, Ageing and Osteoarthritic Joints","volume":"13","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","article-title":"The Epidemiology of Osteoarthritis","volume":"28","author":"Johnson","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.joca.2019.09.009","article-title":"Dual Roles of Misshapen\/NIK-Related Kinase (MINK1) in Osteoarthritis Subtypes through the Activation of TGF\u03b2 Signaling","volume":"28","author":"Yu","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S1097-2765(01)00332-X","article-title":"The TGF\u03b2 Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch","volume":"8","author":"Huse","year":"2001","journal-title":"Mol. Cell"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0014-4827(80)90456-5","article-title":"Reorientation Response of Cells to Repeated Stretch and Recoil of the Substratum","volume":"127","author":"Buck","year":"1980","journal-title":"Exp. Cell Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2019.08.041","article-title":"Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development","volume":"179","author":"Huycke","year":"2019","journal-title":"Cell"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10555-008-9173-4","article-title":"Mechanics, Malignancy, and Metastasis: The Force Journey of a Tumor Cell","volume":"28","author":"Kumar","year":"2009","journal-title":"Cancer Metastasis Rev."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1021\/acsnano.7b02376","article-title":"Nanomechanically Visualizing Drug\u2013Cell Interaction at the Early Stage of Chemotherapy","volume":"11","author":"Wu","year":"2017","journal-title":"ACS Nano"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Nia, H.T., Liu, H., Seano, G., Datta, M., Jones, D., Rahbari, N., Incio, J., Chauhan, V.P., Jung, K., and Martin, J.D. (2016). Solid Stress and Elastic Energy as Measures of Tumour Mechanopathology. Nat. Biomed. Eng., 1.","DOI":"10.1038\/s41551-016-0004"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41551-018-0334-7","article-title":"Solid Stress in Brain Tumours Causes Neuronal Loss and Neurological Dysfunction and Can Be Reversed by Lithium","volume":"3","author":"Seano","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-bioeng-071813-105259","article-title":"The Role of Mechanical Forces in Tumor Growth and Therapy","volume":"16","author":"Jain","year":"2014","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"14800","DOI":"10.1074\/jbc.272.23.14800","article-title":"Phosphorylation of Serine 256 Is Required for cAMP-Dependent Regulatory Exocytosis of the Aquaporin-2 Water Channel","volume":"272","author":"Fushimi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Lin, S.-T., Ma, C.-C., Kuo, K.-T., Su, Y.-F., Wang, W.-L., Chan, T.-H., Su, S.-H., Weng, S.-C., Yang, C.-H., and Lin, S.-L. (2019). Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01308"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.embor.embor711","article-title":"Cyclic AMP Is Sufficient for Triggering the Exocytic Recruitment of Aquaporin-2 in Renal Epithelial Cells","volume":"4","author":"Lorenz","year":"2003","journal-title":"EMBO Rep."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Sandoval, P.C., Claxton, J.S., Lee, J.W., Saeed, F., Hoffert, J.D., and Knepper, M.A. (2016). Systems-Level Analysis Reveals Selective Regulation of Aqp2 Gene Expression by Vasopressin. Sci. Rep., 6.","DOI":"10.1038\/srep34863"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"F43","DOI":"10.1152\/ajprenal.00229.2022","article-title":"Data Resource: Vasopressin-Regulated Protein Phosphorylation Sites in the Collecting Duct","volume":"324","author":"Park","year":"2023","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"F789","DOI":"10.1152\/ajprenal.00281.2019","article-title":"Phosphoproteomic Identification of Vasopressin V2 Receptor-Dependent Signaling in the Renal Collecting Duct","volume":"317","author":"Deshpande","year":"2019","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Eisfeldt, J., Schuy, J., Stattin, E.-L., Kvarnung, M., Falk, A., Feuk, L., and Lindstrand, A. (2022). Multi-Omic Investigations of a 17\u201319 Translocation Links MINK1 Disruption to Autism, Epilepsy and Osteoporosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169392"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"D986","DOI":"10.1093\/nar\/gkac1017","article-title":"GWAS Central: An Expanding Resource for Finding and Visualising Genotype and Phenotype Data from Genome-Wide Association Studies","volume":"51","author":"Beck","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/12\/826\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:47:19Z","timestamp":1760114839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/46\/12\/826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":216,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cimb46120826"],"URL":"https:\/\/doi.org\/10.3390\/cimb46120826","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]}}}