{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:07:06Z","timestamp":1780110426873,"version":"3.54.0"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing\u2013remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU\/day in the high-dose group (HD, n = 23) and 15,960 IU\/month in the low-dose group (LD, n = 29). Significant differences in body weight, height, and age were found between groups. A significant increase in the level of VitD (25(OH)D) was noted in both groups (p &lt; 0.01). A significant increase was observed in the levels of LF and MDA (p &lt; 0.01) and a significant decrease in the concentrations of PSH (p &lt; 0.01), CuZnSOD (p = 0.02), and TOS (p &lt; 0.01). A significant positive correlation was observed between serum VitD and SOD (R = 0.38, p &lt; 0.01) and MnSOD (R = 0.31, p &lt; 0.05), as well as a significant negative correlation between serum VitD and MDA (R = \u22120.31, p = 0.05) at the beginning of the study. At the end of the study, a significant positive correlation was observed between serum VitD and SOD (R = 0.34, p &lt; 0.05) and CuZnSOD (R = 0.51, p &lt; 0.01). In RRMS patients, the VitD doses are probably insufficient to induce a beneficial effect on the pro- and antioxidant balance.<\/jats:p>","DOI":"10.3390\/cimb46120845","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T06:26:12Z","timestamp":1734416772000},"page":"14119-14131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing\u2013Remitting Multiple Sclerosis"],"prefix":"10.3390","volume":"46","author":[{"given":"Martyna","family":"Lis","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Niedziela","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jowita","family":"Adamczyk-Zostawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Zalejska-Fiolka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Szczygie\u0142","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"\u015awi\u0119tek","sequence":"additional","affiliation":[{"name":"Silesia LabMed Research and Implementation Center, Medical University of Silesia in Katowice, 41-808 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Adamczyk-Sowa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Theodosis-Nobelos, P., and Rekka, E.A. 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