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The association of environmental stressors such as pesticides with a sugar-rich diet can contribute to the growing global metabolic disease epidemic through overlapping mechanisms of insulin resistance, inflammation, and metabolic dysregulation. The main aim of this study was to evaluate the behavioral effects of the exposure of Silver crucian carp (Carassius auratus gibelio) to a commercial insecticide formulation containing fipronil, pyriproxyfen, and other additives, as well as sucrose and their mixtures. The behavioral responses in the T-test showed significant abnormalities in the exploratory activity evocative of memory deficits and an increased degree of anxiety in the groups of fish treated with the insecticide formulation and the mixture of the insecticide with sucrose. Aggression, quantified in the mirror-biting test, as biting and the frequency of approaches to the mirror contact zone, was significantly decreased only in the insecticide and sucrose group. All three groups showed behavioral changes reflective of toxicity, but only the combination of the two stress factors, environmental (insecticide) and metabolic (sucrose intake), resulted in pronounced memory alterations.<\/jats:p>","DOI":"10.3390\/cimb46120848","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T06:26:12Z","timestamp":1734416772000},"page":"14168-14189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Influence of Low Doses of Sucrose on Memory Deficits in Fish Exposed to Common Insecticide Based on Fipronil and Pyriproxyfen"],"prefix":"10.3390","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-8911","authenticated-orcid":false,"given":"Viorica","family":"Rarinca","sequence":"first","affiliation":[{"name":"Doctoral School of Geosciences, Faculty of Geography and Geology, \u201cAlexandru Ioan Cuza\u201d University of Iasi, No 20A, Carol I Avenue, 700505 Iasi, Romania"},{"name":"Doctoral School of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i, Carol I Avenue, 20A, 700505 Iasi, Romania"},{"name":"Preclinical Department, Apollonia University, Pacurari Street 11, 700511 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luminita Diana","family":"Hritcu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Veterinary Medicine, Iasi University of Life Sciences, Mihail Sadoveanu Street, No. 3, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-438X","authenticated-orcid":false,"given":"Marian","family":"Burducea","sequence":"additional","affiliation":[{"name":"Research and Development Station for Aquaculture and Aquatic Ecology, \u201cAlexandru Ioan Cuza\u201d University, Carol I, 20A, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-1768","authenticated-orcid":false,"given":"Gabriel","family":"Plavan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, No 20A, Carol I Avenue, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Lefter","sequence":"additional","affiliation":[{"name":"Center of Biomedical Research, Romanian Academy, No. 8, Carol I Avenue, 700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasile","family":"Burlui","sequence":"additional","affiliation":[{"name":"Preclinical Department, Apollonia University, Pacurari Street 11, 700511 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Romila","sequence":"additional","affiliation":[{"name":"Preclinical Department, Apollonia University, Pacurari Street 11, 700511 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Ciobic\u0103","sequence":"additional","affiliation":[{"name":"Preclinical Department, Apollonia University, Pacurari Street 11, 700511 Iasi, Romania"},{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, No 20A, Carol I Avenue, 700505 Iasi, Romania"},{"name":"Center of Biomedical Research, Romanian Academy, No. 8, Carol I Avenue, 700506 Iasi, Romania"},{"name":"Academy of Romanian Scientists, No. 54, Independence Street, Sector 5, 050094 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Todirascu-Ciornea","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, No 20A, Carol I Avenue, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-3001","authenticated-orcid":false,"given":"Cristian-Alin","family":"Barbacariu","sequence":"additional","affiliation":[{"name":"Research and Development Station for Aquaculture and Aquatic Ecology, \u201cAlexandru Ioan Cuza\u201d University, Carol I, 20A, 700505 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11356-014-3471-x","article-title":"Effects of Neonicotinoids and Fipronil on Non-Target Invertebrates","volume":"22","author":"Pisa","year":"2014","journal-title":"Environ. 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