{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:07:00Z","timestamp":1783181220007,"version":"3.54.6"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chung Shan Medical University","award":["CSMU-INT-113-06"],"award-info":[{"award-number":["CSMU-INT-113-06"]}]},{"name":"Chung Shan Medical University","award":["CSMU-INT-113-17"],"award-info":[{"award-number":["CSMU-INT-113-17"]}]},{"name":"Chung Shan Medical University","award":["CMU103-ASIA-06"],"award-info":[{"award-number":["CMU103-ASIA-06"]}]},{"name":"China Medical University","award":["CSMU-INT-113-06"],"award-info":[{"award-number":["CSMU-INT-113-06"]}]},{"name":"China Medical University","award":["CSMU-INT-113-17"],"award-info":[{"award-number":["CSMU-INT-113-17"]}]},{"name":"China Medical University","award":["CMU103-ASIA-06"],"award-info":[{"award-number":["CMU103-ASIA-06"]}]},{"name":"Asia University","award":["CSMU-INT-113-06"],"award-info":[{"award-number":["CSMU-INT-113-06"]}]},{"name":"Asia University","award":["CSMU-INT-113-17"],"award-info":[{"award-number":["CSMU-INT-113-17"]}]},{"name":"Asia University","award":["CMU103-ASIA-06"],"award-info":[{"award-number":["CMU103-ASIA-06"]}]},{"name":"Anyong Biotechnology Inc.","award":["CSMU-INT-113-06"],"award-info":[{"award-number":["CSMU-INT-113-06"]}]},{"name":"Anyong Biotechnology Inc.","award":["CSMU-INT-113-17"],"award-info":[{"award-number":["CSMU-INT-113-17"]}]},{"name":"Anyong Biotechnology Inc.","award":["CMU103-ASIA-06"],"award-info":[{"award-number":["CMU103-ASIA-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Muscle atrophy, through several pathways including increased protein catabolism, leads to adverse effects in cachexia induced by cancer and chemotherapy. Perch essence (PE) is a perch extract rich in branched-chain amino acids and peptides. The present study initially investigated the effects of PE supplementation on muscle atrophy in a mouse model of cancer cachexia induced by C26 cancer cells and compared these effects with those of tryptone. Compared with the tumor-only group, we found that PE supplementation significantly improved body weight, muscle mass, maximum limb grip strength (MLGS), and myosin heavy chain expression in the muscles of tumor-bearing mice. PE also significantly inhibited the expression of factors related to protein degradation, oxidative stress, and inflammation, while enhancing the expression of antioxidant enzymes in tumor-bearing mice. These effects of PE were associated with an increased expression of phosphorylated Akt and forkhead box protein O1, along with a reduced expression of phosphorylated nuclear factor-\u03baB p65 in the muscles of tumor-bearing mice. Furthermore, PE similarly increased MLGS and attenuated muscle atrophy in mice exposed to cisplatin by inhibiting protein degradation. All the therapeutic effects of PE supplementation mentioned above were generally greater than those of tryptone supplementation. These results suggest the potential of PE in protecting against muscle atrophy induced by tumors or chemotherapy.<\/jats:p>","DOI":"10.3390\/cimb47030152","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T08:28:31Z","timestamp":1740558511000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Protective Effects of Perch Essence Against Muscle Atrophy in Cancer Cachexia and Cisplatin Treatment"],"prefix":"10.3390","volume":"47","author":[{"given":"Shu-Lan","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40203, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Senior Citizen Welfare and Long-Term Care Business (Master Program), Hungkuang University, Taichung 433304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-1203","authenticated-orcid":false,"given":"Jiunn-Wang","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Veterinary Pathology, College of Veterinary Medicine, National Chung Hsing University, Taichung 402202, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Han","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-463X","authenticated-orcid":false,"given":"Ling-Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Anyong Biotechnology Inc., Kaohsiung 827012, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2792-4763","authenticated-orcid":false,"given":"Mao-Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Anyong Biotechnology Inc., Kaohsiung 827012, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nutrition Therapy, Jen-Ai Hospital, Taichung 412224, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-5515","authenticated-orcid":false,"given":"Haw-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Chung Shan Medical University, Taichung 40203, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2018.05.006","article-title":"Cancer cachexia: Diagnosis, assessment, and treatment","volume":"127","author":"Sadeghi","year":"2018","journal-title":"Crit. 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