{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:35:12Z","timestamp":1767008112026,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACyT","award":["258043"],"award-info":[{"award-number":["258043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease characterized by cerebellar ataxia and retinal degeneration, caused by an abnormal expansion of the CAG trinucleotide in the coding region of the ATXN7 gene. Currently, in silico analysis is used to explore mechanisms and biological processes through bioinformatics predictions in various neurodegenerative diseases. Therefore, the aim of this study was to identify candidate human gene targets of four miRNAs (hsa-miR-29a-3p, hsa-miR-132-3p, hsa-miR-25-3p, and hsa-miR-92a-3p) involved in pathways that could play an important role in SCA7 pathogenesis through comprehensive in silico analysis including the prediction of miRNA target genes, Gen Ontology enrichment, identification of core genes in KEGG pathways, transcription factors and validated miRNA target genes with the mouse SCA7 transcriptome data. Our results showed the participation of the following pathways: adherens junction, focal adhesion, neurotrophin signaling, endoplasmic reticulum processing, actin cytoskeleton regulation, RNA transport, and apoptosis and dopaminergic synapse. In conclusion, unlike previous studies, we highlight using a bioinformatics approach the core genes and transcription factors involved in the different biological pathways and which ones are targets for the four miRNAs, which, in addition to being associated with neurodegenerative diseases, are also de-regulated in the plasma of patients with SCA7.<\/jats:p>","DOI":"10.3390\/cimb47030170","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T03:22:44Z","timestamp":1740972164000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Silico Analysis of miRNA-Regulated Pathways in Spinocerebellar Ataxia Type 7"],"prefix":"10.3390","volume":"47","author":[{"given":"Ver\u00f3nica Marusa","family":"Borgonio-Cuadra","sequence":"first","affiliation":[{"name":"Laboratory of Genomic Medicine, Department of Genetics, Instituto Nacional de Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"},{"name":"Center for Research in Health Sciences, Faculty of Health Sciences, Universidad An\u00e1huac Mexico Norte, Mexico City 52786, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-371X","authenticated-orcid":false,"given":"Aranza","family":"Meza-Dorantes","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering and Sciences, Tecnologico de Monterrey, Campus Ciudad de Mexico, Mexico City 14380, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-508X","authenticated-orcid":false,"given":"Nonanzit","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-0897","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Medicine, Department of Genetics, Instituto Nacional de Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"},{"name":"Department of Bioengineering, School of Engineering and Sciences, Tecnologico de Monterrey, Campus Ciudad de Mexico, Mexico City 14380, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/0971-5916.155556","article-title":"Spinocerebellar Ataxia 7 (SCA7) in Indian Population: Predilection of ATXN7-CAG Expansion Mutation in an Ethnic Population","volume":"141","author":"Faruq","year":"2015","journal-title":"Indian J. 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