{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:00:44Z","timestamp":1792789244613,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Institutes of T\u00fcrkiye (TUSEB)","award":["16824"],"award-info":[{"award-number":["16824"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative disease, and its prevalence is expected to double in the next 30 years. Currently, no effective treatment exists for Parkinson\u2019s disease. Thus, the research has focused on discovering new natural compounds with strong neuroprotective potential. This study aimed to investigate the effects of the methanol extract of Desmodesmus arthrodesmiformis EM13 (DaMe) on the mitochondrial damage pathway in an in vitro model of PD. The isolate of Desmodesmus arthrodesmiformis EM13 was first grown under appropriate culture conditions, and then the extract (DaMe) was prepared for use in the experiments. The total lipid and protein contents, fatty acid composition, and elemental content of DaMe were subsequently determined. Human SH-SY5Y neuroblastoma cells were pretreated with nontoxic concentrations of DaMe before 6-hydroxydopamine (6-OHDA) toxicity. Pretreatment with DaMe at concentrations of 100, 250, and 500 \u00b5g\/mL showed a neuroprotective effect on 6-OHDA-induced SH-SY5Y neuroblastoma cells by decreasing the reactive oxygen species (ROS) production, decreasing the total oxidant status (TOS), increasing the total antioxidant capacity (TAC), increasing the mitochondrial membrane potential (\u0394\u03a8m), decreasing the oxidative DNA damage, and regulating gene expressions related to PD and apoptosis. Given the results of our study, we suggest that DaMe can be used as a natural source for producing drugs and dietary supplements intended to treat PD.<\/jats:p>","DOI":"10.3390\/cimb47030174","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:55:08Z","timestamp":1741236908000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Desmodesmus Extract as a Mitochondrion-Targeted Neuroprotective Agent in Parkinson\u2019s Disease: An In Vitro Study"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-5769","authenticated-orcid":false,"given":"Muazzez","family":"Derya-Andeden","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Erciyes University, 38030 Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Altin-Celik","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Erciyes University, 38030 Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-8990","authenticated-orcid":false,"given":"Enver Ersoy","family":"Andeden","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Art and Science, Hac\u0131 Bekta\u015f Veli University, 50300 Nev\u015fehir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-5813","authenticated-orcid":false,"given":"Hamiyet","family":"Donmez-Altuntas","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Erciyes University, 38030 Kayseri, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref_1","unstructured":"Kouli, A., Torsney, K.M., and Kuan, W.-L. 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