{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:28:47Z","timestamp":1773098927557,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing traditional Chinese Medicine inheritance and Innovation team project","award":["2023090006KJZX2022WJW008"],"award-info":[{"award-number":["2023090006KJZX2022WJW008"]}]},{"name":"Chongqing traditional Chinese Medicine inheritance and Innovation team project","award":["KJQN202315109"],"award-info":[{"award-number":["KJQN202315109"]}]},{"name":"Chongqing traditional Chinese Medicine inheritance and Innovation team project","award":["KJQN202215112"],"award-info":[{"award-number":["KJQN202215112"]}]},{"name":"Chongqing traditional Chinese Medicine inheritance and Innovation team project","award":["KJZD-M202215101"],"award-info":[{"award-number":["KJZD-M202215101"]}]},{"name":"Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["2023090006KJZX2022WJW008"],"award-info":[{"award-number":["2023090006KJZX2022WJW008"]}]},{"name":"Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["KJQN202315109"],"award-info":[{"award-number":["KJQN202315109"]}]},{"name":"Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["KJQN202215112"],"award-info":[{"award-number":["KJQN202215112"]}]},{"name":"Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["KJZD-M202215101"],"award-info":[{"award-number":["KJZD-M202215101"]}]},{"name":"Chongqing Education Commission","award":["2023090006KJZX2022WJW008"],"award-info":[{"award-number":["2023090006KJZX2022WJW008"]}]},{"name":"Chongqing Education Commission","award":["KJQN202315109"],"award-info":[{"award-number":["KJQN202315109"]}]},{"name":"Chongqing Education Commission","award":["KJQN202215112"],"award-info":[{"award-number":["KJQN202215112"]}]},{"name":"Chongqing Education Commission","award":["KJZD-M202215101"],"award-info":[{"award-number":["KJZD-M202215101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Rhodiola crenulata (RC) is a traditional herb and functional food that has demonstrated beneficial effects in improving physical function, enhancing work capacity, alleviating fatigue, and preventing altitude sickness. Additionally, RC has shown promising effects in the treatment of non-alcoholic fatty liver disease (NAFLD), although its specific bioactive components and underlying mechanisms remain unclear. In this study, ultra-high-performance liquid chromatography\u2013mass spectrometry (UHPLC-MS) combined with network pharmacology was employed to identify six potential bioactive compounds from the serum of rats treated with RC\u2014Salidroside, Tyrosol, Crenulatin, Catechin gallate, Eriodictyol, and Rhodiooctanoside\u2014that may contribute to its therapeutic effects on NAFLD. The efficacy of these compounds in improving NAFLD was assessed in vitro using HepG2 cells exposed to Palmitic acid (PA), and it was found that Catechin gallate exhibited a significant effect in reducing lipid accumulation in HepG2 cells. Furthermore, based on network pharmacology predictions, molecular docking studies suggested that the primary targets of Catechin gallate in alleviating fatty liver might include ABCB1, DYRK1A, PGD, and FUT4. Molecular dynamics simulations revealed stable binding interactions between Catechin gallate and these four target proteins. This study clarifies the material basis of RC in the treatment of NAFLD and provides a theoretical foundation for the application of RC and Catechin gallate as functional additives for the management of NAFLD.<\/jats:p>","DOI":"10.3390\/cimb47050324","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:16:12Z","timestamp":1746090972000},"page":"324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultra-High-Performance Liquid Chromatography\u2013Tandem Mass Spectrometry and Network Pharmacology Reveal the Mechanisms of Rhodiola crenulata in Improving Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"47","author":[{"given":"Xin","family":"Zeng","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"},{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"},{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyi","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengdan","family":"Deng","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yi","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yao","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.fshw.2022.03.031","article-title":"Polygonatum sibiricum polysaccharides protect against obesity and non-alcoholic fatty liver disease in rats fed a high-fat diet","volume":"11","author":"Zeng","year":"2022","journal-title":"Food Sci. 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