{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:08Z","timestamp":1791296828821,"version":"4.1.0"},"reference-count":270,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development project in China","award":["2016YFD0400603"],"award-info":[{"award-number":["2016YFD0400603"]}]},{"name":"National Key Research and Development project in China","award":["KYCX24_3731"],"award-info":[{"award-number":["KYCX24_3731"]}]},{"name":"Postgraduate Research and Practice Innovation Program of Jiangsu Province in China","award":["2016YFD0400603"],"award-info":[{"award-number":["2016YFD0400603"]}]},{"name":"Postgraduate Research and Practice Innovation Program of Jiangsu Province in China","award":["KYCX24_3731"],"award-info":[{"award-number":["KYCX24_3731"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Cancer is a major global health issue, and exercise has become a key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, and aiding recovery, especially for survivors. However, the exact mechanisms, such as how exercise reduces cancer risk or enhances treatment, are still unclear. Current research often focuses on specific cancer types, ignoring the diverse needs of patients. This limits the development of personalized exercise plans. Additionally, there is insufficient comparison of exercise types\u2014like aerobic, resistance, and high-intensity interval training\u2014regarding their adverse effects and long-term benefits. The best combination of exercises and personalized strategies remains unknown. This review underscores the contribution of physical exercise to cancer prevention and treatment, emphasizing its positive effects on reducing fatigue, improving physical strength, and enhancing mental health. It also explores the molecular mechanisms of regulating tumor immunity and energy metabolism. Additionally, the article covers criteria for selecting exercise types and intensities, and the development of personalized exercise plans. Finally, it provides guidelines for exercise prescriptions and suggests future research directions to improve interventions for cancer patients.<\/jats:p>","DOI":"10.3390\/cimb47050374","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:10:46Z","timestamp":1747721446000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Impact and Molecular Mechanisms of Exercise in Cancer Therapy"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6128-5847","authenticated-orcid":false,"given":"Yingjie","family":"Sun","sequence":"first","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8779","authenticated-orcid":false,"given":"Qiguan","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e200023","DOI":"10.1590\/1981-22562020023.200023","article-title":"Prevalence of diagnosis and types of cancer in the elderly: Data from National Health Survey 2013","volume":"23","author":"Francisco","year":"2020","journal-title":"Rev. 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