{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:12:29Z","timestamp":1790712749539,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technology Development Program","award":["RS-2022--00167168"],"award-info":[{"award-number":["RS-2022--00167168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>The pathogenesis of inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn\u2019s disease, remains incompletely understood. Amomum villosum Lour. (Zingiberaceae) is a traditional herbal medicine used across Asia to treat digestive and inflammatory disorders. This study investigated the therapeutic effects of a water extract derived from the fruits of AV (referred to as AVE) in a mouse model of colitis induced by dextran sulfate sodium (DSS). The protective effects of AVE were evaluated by monitoring changes in body weight and colon length, as well as histological and molecular markers of inflammation. Neutrophil infiltration and levels of inflammatory cytokines in colon tissue and serum were assessed, and the integrity of the intestinal epithelial barrier was examined via Western blot analysis. Treatment with AVE significantly alleviated DSS-induced colitis, as evidenced by improved body weight, longer colon length, and reduced inflammatory responses. AVE administration restored tight junction protein expression (zonula occludens-1 [ZO-1] and occludin), suppressed phosphorylation of mitogen-activated protein kinases\u2014specifically, extracellular signal-regulated kinase (ERK) and p38\u2014and inhibited the expression of inflammatory mediators including tumor necrosis factor-alpha (TNF-\u03b1), cyclooxygenase-2 (COX-2), interleukin (IL)-6, IL-1\u03b2, and myeloperoxidase (MPO) activity. These findings suggest that oral AVE treatment effectively protects against experimental colitis by modulating inflammatory signaling and preserving epithelial barrier integrity. Further studies are warranted to explore the clinical potential and safety of AVE in the management of IBD.<\/jats:p>","DOI":"10.3390\/cimb47060389","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:58:09Z","timestamp":1747994289000},"page":"389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Inflammatory Effects of Amomum villosum Extract on Dextran Sodium Sulfate-Induced Colitis in Mice"],"prefix":"10.3390","volume":"47","author":[{"given":"Han-Byeol","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryeo Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Ilwonbio Co., Ltd., Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Sang","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Research Center of Traditional Korean Medicine, Wonkwang University, Iksan-daero, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hun","family":"Jang","sequence":"additional","affiliation":[{"name":"Ilwonbio Co., Ltd., Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Seul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ouk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Beom","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea"},{"name":"Ilwonbio Co., Ltd., Iksan 54538, Republic of Korea"},{"name":"Research Center of Traditional Korean Medicine, Wonkwang University, Iksan-daero, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pastorelli, L., De Salvo, C., Mercado, J.R., Vecchi, M., and Pizarro, T.T. 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