{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:34:42Z","timestamp":1784770482811,"version":"3.55.0"},"reference-count":114,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Sleep deprivation (SD) induces significant neurobiological changes, including oxidative stress, neuroinflammation, and behavioural impairments. This study was designed as a proof of concept to assess the potential for modulating the effects of SD through a short-term seven-day administration of Cornus mas (C. mas) in a rapid eye movement (REM) SD rodent paradigm. Adult male Wistar rats were randomised in four groups (n = 7): control, C. mas (CM), sleep deprivation (SD), and sleep deprivation with C. mas (SD + CM). Behaviourally, SD induced hyperactivity and hyperlocomotion. SD determined histological alterations in the prefrontal cortex and corpus callosum myelin coupled with ultrastructural mitochondrial and cellular abnormalities in the prefrontal cortex, hippocampus, and pineal gland. Despite evidence of systemic oxidative stress coupled with decreased serum GABA and BDNF following SD, no significant changes were observed in redox markers or inflammatory cytokine levels (TNF-\u03b1, IL-1\u03b2) within the prefrontal cortex or hippocampus. C. mas extract has shown an overall modest modulatory action, mainly evidenced on behavioural, histological, and ultrastructural parameters. Taken together, these findings highlight behavioural changes and region-specific molecular and structural abnormalities following prolonged REM SD in rats.<\/jats:p>","DOI":"10.3390\/cimb47060399","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T06:30:26Z","timestamp":1748413826000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular Effects of Cornelian Cherry Fruit (Cornus mas L.) Extract on Sleep Deprivation-Induced Oxidative Stress, Cytokine Dysregulation, and Behavioural Changes in Wistar Rats"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-4631","authenticated-orcid":false,"given":"Vlad Sever","family":"Neculicioiu","sequence":"first","affiliation":[{"name":"Department of Microbiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Colosi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Sevastre-Berghian","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-5920","authenticated-orcid":false,"given":"Dan Alexandru","family":"Toc","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-2893","authenticated-orcid":false,"given":"Hora\u021biu Alexandru","family":"Colosi","sequence":"additional","affiliation":[{"name":"Division of Medical Informatics and Biostatistics, Department of Medical Education, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-6513","authenticated-orcid":false,"given":"Luminita","family":"David","sequence":"additional","affiliation":[{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-5851","authenticated-orcid":false,"given":"Mara","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-0777","authenticated-orcid":false,"given":"Ana-Maria","family":"Vlase","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 8 Victor Babe\u0219 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-2559","authenticated-orcid":false,"given":"Vlad Alexandru","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babe\u0219-Bolyai University, 44 Republicii Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-0072","authenticated-orcid":false,"given":"Carmen","family":"Costache","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-5132","authenticated-orcid":false,"given":"\u015eoimi\u0163a Mihaela","family":"Suciu","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-0803","authenticated-orcid":false,"given":"Simona","family":"Clichici","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Neculicioiu, V.S., Colosi, I.A., Costache, C., Sevastre-Berghian, A., and Clichici, S. (2022). Time to Sleep?\u2014A Review of the Impact of the COVID-19 Pandemic on Sleep and Mental Health. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19063497"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.5888\/pcd20.220400","article-title":"Prevalence and Geographic Patterns of Self-Reported Short Sleep Duration Among US Adults, 2020","volume":"20","author":"Pankowska","year":"2023","journal-title":"Prev. Chronic Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.5888\/pcd20.220344","article-title":"Sleep Duration, Mental Health, and Increased Difficulty Doing Schoolwork Among High School Students During the COVID-19 Pandemic","volume":"20","author":"Sliwa","year":"2023","journal-title":"Prev. Chronic Dis."},{"key":"ref_4","unstructured":"Centers for Disease Control and Prevention (2024, November 11). High School Youth Risk Behavior Survey Data, Available online: https:\/\/nccd.cdc.gov\/Youthonline."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.conb.2013.02.008","article-title":"Sleep Deprivation and Neurobehavioral Dynamics","volume":"23","author":"Basner","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.sleep.2016.08.006","article-title":"Short Sleep Duration and Health Outcomes: A Systematic Review, Meta-Analysis, and Meta-Regression","volume":"32","author":"Itani","year":"2017","journal-title":"Sleep Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11357-020-00312-y","article-title":"Effects of Sleep Deprivation on Endothelial Function in Adult Humans: A Systematic Review","volume":"43","author":"Holmer","year":"2021","journal-title":"Geroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/JOE-21-0155","article-title":"The Links between Sleep Duration, Obesity and Type 2 Diabetes Mellitus","volume":"252","author":"Antza","year":"2021","journal-title":"J. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.tins.2022.05.007","article-title":"Neural Consequences of Chronic Sleep Disruption","volume":"45","author":"Zamore","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hill, V.M., O\u2019Connor, R.M., Sissoko, G.B., Irobunda, I.S., Leong, S., Canman, J.C., Stavropoulos, N., and Shirasu-Hiza, M. (2018). A Bidirectional Relationship between Sleep and Oxidative Stress in Drosophila. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2005206"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Neculicioiu, V.S., Colosi, I.A., Costache, C., Toc, D.A., Sevastre-Berghian, A., Colosi, H.A., and Clichici, S. (2023). Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review. Antioxidants, 12.","DOI":"10.3390\/antiox12081600"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"234952","DOI":"10.1155\/2015\/234952","article-title":"Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review","volume":"2015","author":"Villafuerte","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Davinelli, S., Medoro, A., Savino, R., and Scapagnini, G. (2024). Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2. Cell. Mol. Neurobiol., 44.","DOI":"10.1007\/s10571-024-01487-0"},{"key":"ref_14","first-page":"23743735241241180","article-title":"Factors Influencing Use of Medicinal Herbs","volume":"11","author":"Krsnik","year":"2024","journal-title":"J. Patient Exp."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100904","DOI":"10.1016\/j.jaim.2024.100904","article-title":"Traditional and Contemporary Herbal Medicines in Management of Cancer: A Scoping Review","volume":"15","author":"Imtiaz","year":"2024","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.5897\/AJB09.1722","article-title":"Selected Cultivars of Cornelian Cherry (Cornus mas L.) as a New Food Source for Human Nutrition","volume":"9","author":"Rop","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tenuta, M.C., Deguin, B., Loizzo, M.R., Cuyamendous, C., Bonesi, M., Sicari, V., Trabalzini, L., Mitaine-Offer, A.-C., Xiao, J., and Tundis, R. (2022). An Overview of Traditional Uses, Phytochemical Compositions and Biological Activities of Edible Fruits of European and Asian Cornus Species. Foods, 11.","DOI":"10.3390\/foods11091240"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jep.2016.09.042","article-title":"Cornus mas L. (Cornelian Cherry), an Important European and Asian Traditional Food and Medicine: Ethnomedicine, Phytochemistry and Pharmacology for Its Commercial Utilization in Drug Industry","volume":"193","author":"Dinda","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"117068","DOI":"10.1016\/j.jep.2023.117068","article-title":"Effects of Cornus mas L. on Anthropometric and Biochemical Parameters among Metabolic Associated Fatty Liver Disease Patients: Randomized Clinical Trial","volume":"318","author":"Bayram","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clnesp.2023.04.018","article-title":"Effect of Cornus mas L. Fruit Extract on Blood Pressure, Anthropometric and Body Composition Indices in Patients with Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Trial","volume":"56","author":"Yarhosseini","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1002\/ptr.7143","article-title":"The Effect of Cornus mas Extract Consumption on Bone Biomarkers and Inflammation in Postmenopausal Women: A Randomized Clinical Trial","volume":"35","author":"Aryaeian","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00246-013-0693-5","article-title":"Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus mas L. Supplementation on Dyslipidemic Children and Adolescents","volume":"34","author":"Asgary","year":"2013","journal-title":"Pediatr. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1078\/0944-7113-00060","article-title":"Synergy and Other Interactions in Phytomedicines","volume":"8","author":"Williamson","year":"2001","journal-title":"Phytomedicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2875-10-S1-S4","article-title":"Whole Plant Extracts versus Single Compounds for the Treatment of Malaria: Synergy and Positive Interactions","volume":"10","author":"Rasoanaivo","year":"2011","journal-title":"Malar. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2018.07.050","article-title":"Polyphenols, Food and Pharma. Current Knowledge and Directions for Future Research","volume":"156","author":"Moreno","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.21307\/ane-2017-035","article-title":"Effects of Cornus mas L. and Morus rubra L. Extracts on Penicillin-Induced Epileptiform Activity: An Electrophysiological and Biochemical Study","volume":"77","author":"Per","year":"2017","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jff.2016.07.004","article-title":"Antioxidant Activity of Cornelian Cherry (Cornus mas L.) Fruits Extract and the in Vivo Evaluation of Its Anti-Inflammatory Effects","volume":"26","author":"Moldovan","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jphotobiol.2018.12.006","article-title":"UV-Light Mediated Green Synthesis of Silver and Gold Nanoparticles Using Cornelian Cherry Fruit Extract and Their Comparative Effects in Experimental Inflammation","volume":"191","author":"Filip","year":"2019","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_29","first-page":"91","article-title":"Hepatoprotective Effect of Cornus mas Fruits Extract on Serum Biomarkers in Methotrexate-Induced Liver Injury in Male Rats","volume":"1","author":"Saei","year":"2016","journal-title":"Pharmacologyonline"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"847368","DOI":"10.1155\/2014\/847368","article-title":"The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats","volume":"2014","author":"Francik","year":"2014","journal-title":"Sci. World J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.22364\/eeb.14.16","article-title":"Effect of Cornus mas Fruit Flavonoids on Memory Retention, Level of Plasma Glucose and Lipids in an Intracerebroventricular Streptozotocin-Induced Experimental Alzheimer\u2019s Disease Model in Wistar Rats","volume":"14","author":"Darbandi","year":"2016","journal-title":"Environ. Exp. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent","volume":"Volume 299","author":"Packer","year":"1999","journal-title":"Methods in Enzymology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Moldovan, B., and David, L. (2020). Influence of Different Sweeteners on the Stability of Anthocyanins from Cornelian Cherry Juice. Foods, 9.","DOI":"10.3390\/foods9091266"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Vlase, A.-M., Toiu, A., Tomu\u021b\u0103, I., Vlase, L., Muntean, D., Casian, T., Fize\u0219an, I., Nad\u0103\u0219, G.C., Novac, C.\u0218., and T\u0103ma\u0219, M. (2022). Epilobium Species: From Optimization of the Extraction Process to Evaluation of Biological Properties. Antioxidants, 12.","DOI":"10.3390\/antiox12010091"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gligor, O., Clichici, S., Moldovan, R., Muntean, D., Vlase, A.-M., Nad\u0103\u0219, G.C., Filip, G.A., Vlase, L., and Cri\u0219an, G. (2022). Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts. Plants, 12.","DOI":"10.3390\/plants12010096"},{"key":"ref_36","first-page":"17","article-title":"The Phytochemical Analysis and Antioxidant Capacity Determination of Five Hypericum Species","volume":"67","author":"Sautreau","year":"2022","journal-title":"Stud. Univ. Babes-Bolyai Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.15835\/nbha4319644","article-title":"Phenolic Compounds and Antifungal Activity of Hedera helix L. (Ivy) Flowers and Fruits","volume":"43","author":"Parvu","year":"2015","journal-title":"Not. Bot. Horti Agrobot. Cluj-Napoca"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Solcan, M.-B., Fize\u0219an, I., Vlase, L., Vlase, A.-M., Rusu, M.E., Mate\u0219, L., Petru, A.-E., Cre\u0219tin, I.-V., Tomu\u021b\u01ce, I., and Popa, D.-S. (2023). Phytochemical Profile and Biological Activities of Extracts Obtained from Young Shoots of Blackcurrant (Ribes nigrum L.), European Blueberry (Vaccinium myrtillus L.), and Mountain Cranberry (Vaccinium vitis-idaea L.). Horticulturae, 9.","DOI":"10.3390\/horticulturae9111163"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pa\u0219ca, D., Frangiamone, M., Mangiapelo, L., Vila-Donat, P., M\u00eerza, O., Vlase, A.-M., Miere, D., Filip, L., Ma\u00f1es, J., and Loghin, F. (2024). Phytochemical Characterization of Bilberries and Their Potential as a Functional Ingredient to Mitigate Ochratoxin A Toxicity in Cereal-Based Products. Nutrients, 16.","DOI":"10.3390\/nu16183137"},{"key":"ref_40","first-page":"351","article-title":"Evaluation of the Antioxidant and Antibacterial Potential of Bioactive Compounds from Ajuga reptans Extracts","volume":"65","author":"Toiu","year":"2017","journal-title":"Farmacia"},{"key":"ref_41","first-page":"498","article-title":"Polyphenolic Content and Antioxidant Activity of Chrysanthemum parthenium Extract","volume":"64","author":"Hanganu","year":"2016","journal-title":"Farmacia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2004.01.019","article-title":"Sleep Deprivation Induced by the Modified Multiple Platform Technique: Quantification of Sleep Loss and Recovery","volume":"1004","author":"Machado","year":"2004","journal-title":"Brain Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/joor.12904","article-title":"Paradoxical Sleep Deprivation Induces Differential Biological Response in Rat Masticatory Muscles: Inflammation, Autophagy and Myogenesis","volume":"47","author":"Yujra","year":"2020","journal-title":"J. Oral Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lfs.2019.04.006","article-title":"Chronic Paradoxical Sleep Deprivation-Induced Depression-like Behavior, Energy Metabolism and Microbial Changes in Rats","volume":"225","author":"Ma","year":"2019","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijporl.2018.07.003","article-title":"Effect of Sleep Deprivation on Hearing Levels in Rats","volume":"112","author":"Jung","year":"2018","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2015.03.053","article-title":"Effects of the Aqueous Extract of Pimpinella anisum L. Seeds on Exploratory Activity and Emotional Behavior in Rats Using the Open Field and Elevated plus Maze Tests","volume":"168","author":"Gamberini","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The Use of the Elevated Plus Maze as an Assay of Anxiety-Related Behavior in Rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/clinchem\/37.7.1273","article-title":"Improved Fluorometric Determination of Malonaldehyde","volume":"37","author":"Conti","year":"1991","journal-title":"Clin. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3357\/ASEM.2305.2008","article-title":"Glutathione Metabolism under High-Altitude Stress and Effect of Antioxidant Supplementation","volume":"79","author":"Vats","year":"2008","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jfca.2014.12.016","article-title":"Iridoids and Anthocyanins in Cornelian Cherry (Cornus mas L.) Cultivars","volume":"40","author":"Kucharska","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00217-024-04513-z","article-title":"Cornelian Cherry (Cornus mas L.) as a Promising Source of Antioxidant Phenolic Substances and Minerals","volume":"250","author":"Grygorieva","year":"2024","journal-title":"Eur. Food Res. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/bdi.12838","article-title":"Lithium Acts to Modulate Abnormalities at Behavioral, Cellular, and Molecular Levels in Sleep Deprivation-Induced Mania-like Behavior","volume":"22","author":"Andrabi","year":"2020","journal-title":"Bipolar Disord."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00213-024-06566-0","article-title":"Chronic REM Sleep Deprivation Leads to Manic- and OCD-Related Behaviors, and Decreases Hippocampal BDNF Expression in Female Rats","volume":"241","author":"Abbasi","year":"2024","journal-title":"Psychopharmacology"},{"key":"ref_55","first-page":"pyu031","article-title":"Protein Kinase C Inhibition Rescues Manic-like Behaviors and Hippocampal Cell Proliferation Deficits in the Sleep Deprivation Model of Mania","volume":"18","author":"Abrial","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbr.2007.09.012","article-title":"Behavioural Sensitization to Repeated Sleep Deprivation in a Mice Model of Mania","volume":"187","author":"Benedetti","year":"2008","journal-title":"Behav. Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/bdi.12503","article-title":"Lithium Ameliorates Sleep Deprivation-Induced Mania-like Behavior, Hypothalamic-Pituitary-Adrenal (HPA) Axis Alterations, Oxidative Stress and Elevations of Cytokine Concentrations in the Brain and Serum of Mice","volume":"19","author":"Valvassori","year":"2017","journal-title":"Bipolar Disord."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neubiorev.2016.06.028","article-title":"Effects of Experimental Sleep Deprivation on Anxiety-like Behavior in Animal Research: Systematic Review and Meta-Analysis","volume":"68","author":"Pires","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.sleep.2016.07.019","article-title":"Effects of Acute Sleep Deprivation on State Anxiety Levels: A Systematic Review and Meta-Analysis","volume":"24","author":"Pires","year":"2016","journal-title":"Sleep Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/19768354.2021.1902854","article-title":"Alteration of Fear Behaviors in Sleep-Deprived Adolescent Rats: Increased Fear Expression and Delayed Fear Extinction","volume":"25","author":"Jung","year":"2021","journal-title":"Animal Cells Syst."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9452127","DOI":"10.1155\/2018\/9452127","article-title":"Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus","volume":"2018","author":"Han","year":"2018","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.21037\/atm-21-3872","article-title":"Propofol Protects Hippocampal Neurons in Sleep-Deprived Rats by Inhibiting Mitophagy and Autophagy","volume":"9","author":"Dai","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11325-022-02591-5","article-title":"Propofol-Induced Sleep Ameliorates Cognition Impairment in Sleep-Deprived Rats","volume":"27","author":"Lu","year":"2023","journal-title":"Sleep Breath."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s41105-023-00450-8","article-title":"Dexmedetomidine Prevents Spatial Learning and Memory Impairment Induced by Chronic REM Sleep Deprivation in Rats","volume":"21","author":"Zhang","year":"2023","journal-title":"Sleep Biol. Rhythms"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.12659\/MSM.913839","article-title":"Effects of Sleep Deprivation (SD) on Rats via ERK1\/2 Signaling Pathway","volume":"25","author":"Wang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Aboufares El Alaoui, A., Buhl, E., Galizia, S., Hodge, J.J.L., de Vivo, L., and Bellesi, M. (2023). Increased Interaction between Endoplasmic Reticulum and Mitochondria Following Sleep Deprivation. BMC Biol., 21.","DOI":"10.1186\/s12915-022-01498-7"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.5665\/sleep.5644","article-title":"Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex","volume":"39","author":"Nelson","year":"2016","journal-title":"Sleep"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11055-010-9271-y","article-title":"Morphofunctional Analysis of the Effects of Total Sleep Deprivation on the CNS in Rats","volume":"40","author":"Abushov","year":"2010","journal-title":"Neurosci. Behav. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"zsy034","DOI":"10.1093\/sleep\/zsy034","article-title":"Myelin Modifications after Chronic Sleep Loss in Adolescent Mice","volume":"41","author":"Bellesi","year":"2018","journal-title":"Sleep"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Elvs\u00e5shagen, T., Norbom, L.B., Pedersen, P.\u00d8., Quraishi, S.H., Bj\u00f8rnerud, A., Malt, U.F., Groote, I.R., and Westlye, L.T. (2015). Widespread Changes in White Matter Microstructure after a Day of Waking and Sleep Deprivation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127351"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Simayi, R., Ficiar\u00e0, E., Faniyan, O., Cerd\u00e1n Cerd\u00e1, A., Aboufares El Alaoui, A., Fiorini, R., Cutignano, A., Piscitelli, F., And\u00fajar, P., and Santos, A. (2023). Sleep Loss Impairs Myelin Function by Altering Cholesterol Metabolism in Oligodendroglia. bioRxiv.","DOI":"10.1101\/2023.11.27.568716"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(01)02714-7","article-title":"Influence of Sleep Deprivation Coupled with Administration of Melatonin on the Ultrastructure of Rat Pineal Gland","volume":"910","author":"Lan","year":"2001","journal-title":"Brain Res."},{"key":"ref_73","first-page":"102","article-title":"Light and Electron Microscopic Examination of Pineal Gland in Rats Exposed to Constant Light and Constant Darkness","volume":"25","author":"Kus","year":"2004","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00429-014-0716-x","article-title":"Early-Life Sleep Deprivation Persistently Depresses Melatonin Production and Bio-Energetics of the Pineal Gland: Potential Implications for the Development of Metabolic Deficiency","volume":"220","author":"Chen","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chang, H.-M., Lin, H.-C., Cheng, H.-L., Liao, C.-K., Tseng, T.-J., Renn, T.-Y., Lan, C.-T., and Chen, L.-Y. (2021). Melatonin Successfully Rescues the Hippocampal Molecular Machinery and Enhances Anti-Oxidative Activity Following Early-Life Sleep Deprivation Injury. Antioxidants, 10.","DOI":"10.3390\/antiox10050774"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0306-9877(94)90071-X","article-title":"The Free Radical Flux Theory of Sleep","volume":"43","author":"Reimund","year":"1994","journal-title":"Med. Hypotheses"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biom5010194","article-title":"Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus","volume":"5","author":"Nowotny","year":"2015","journal-title":"Biomolecules"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0753-3322(03)00043-X","article-title":"The Importance of Glutathione in Human Disease","volume":"57","author":"Townsend","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.5665\/sleep.4244","article-title":"Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats","volume":"37","author":"Everson","year":"2014","journal-title":"Sleep"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u039aB in Oxidative Stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence Between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00010.2018","article-title":"The Sleep-Immune Crosstalk in Health and Disease","volume":"99","author":"Besedovsky","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.18632\/aging.202503","article-title":"Sleep Deprivation Aggravates Brain Injury after Experimental Subarachnoid Hemorrhage via TLR4-MyD88 Pathway","volume":"13","author":"Xu","year":"2021","journal-title":"Aging"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Yin, C., Zhang, M., Cheng, L., Ding, L., Lv, Q., Huang, Z., Zhou, J., Chen, J., Wang, P., and Zhang, S. (2024). Melatonin Modulates TLR4\/MyD88\/NF-\u039aB Signaling Pathway to Ameliorate Cognitive Impairment in Sleep-Deprived Rats. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1430599"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","article-title":"Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation","volume":"80","author":"Irwin","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3233\/JAD-191317","article-title":"Activation of Inflammation Is Associated with Amyloid-\u03b2 Accumulation Induced by Chronic Sleep Restriction in Rats","volume":"74","author":"Liu","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/23328940.2022.2109932","article-title":"Sleep Disruption Induces Activation of Inflammation and Heightens Risk for Infectious Disease: Role of Impairments in Thermoregulation and Elevated Ambient Temperature","volume":"10","author":"Irwin","year":"2023","journal-title":"Temperature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1556\/1326.2022.01052","article-title":"Extraction and Quantification of Melatonin in Cornelian Cherry (Cornus mas L.) by Ultra-Fast Liquid Chromatography Coupled to Fluorescence Detector (UFLC-FD)","volume":"35","year":"2023","journal-title":"Acta Chromatogr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/gerona\/glq099","article-title":"Jerte Valley Cherry-Enriched Diets Improve Nocturnal Rest and Increase 6-Sulfatoxymelatonin and Total Antioxidant Capacity in the Urine of Middle-Aged and Elderly Humans","volume":"65","author":"Garrido","year":"2010","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.exger.2012.05.003","article-title":"The Consumption of a Jerte Valley Cherry Product in Humans Enhances Mood, and Increases 5-Hydroxyindoleacetic Acid but Reduces Cortisol Levels in Urine","volume":"47","author":"Garrido","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00394-011-0263-7","article-title":"Effect of Tart Cherry Juice (Prunus cerasus) on Melatonin Levels and Enhanced Sleep Quality","volume":"51","author":"Howatson","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-079X.1994.tb00107.x","article-title":"Pharmacological Effects of Melatonin Treatment on Both Locomotor Activity and Brain Serotonin Release in Rats","volume":"17","author":"Chuang","year":"1994","journal-title":"J. Pineal Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopha.2018.08.117","article-title":"Sedative-Hypnotic like Effect of 5-Methoxyflavone in Mice and Investigation on Possible Mechanisms by In Vivo and In Silico Methods","volume":"108","author":"Shanmugasundaram","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2025.03.004","article-title":"Tangeretin Enhances Sedative Activity of Diazepam in Swiss Mice through GABAA Receptor Interaction: In Vivo and in Silico Approaches","volume":"572","author":"Bhuia","year":"2025","journal-title":"Neuroscience"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s11064-013-1092-2","article-title":"Antioxidant Effects of Nerolidol in Mice Hippocampus after Open Field Test","volume":"38","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"61","DOI":"10.30574\/gscbps.2021.17.3.0351","article-title":"Medicinal Plants Possess Sedative and Anxiolytic Effect with Emphasis on Their Mechanisms of Action","volume":"17","year":"2021","journal-title":"GSC Biol. Pharm. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"29","DOI":"10.17795\/ajnpp-38787","article-title":"Alpha-Pinene as the Main Component of Ducrosia anethifolia (Boiss) Essential Oil Is Responsible for Its Effect on Locomotor Activity in Rats","volume":"3","author":"Zamyad","year":"2016","journal-title":"Avicenna J. Neuro Psycho Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2006.04.004","article-title":"Central Nervous System Depressant Action of Flavonoid Glycosides","volume":"539","author":"Wasowski","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Czerwi\u0144ska, M.E., and Melzig, M.F. (2018). Cornus mas and Cornus officinalis\u2014Analogies and Differences of Two Medicinal Plants Traditionally Used. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00894"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Xu, J., Qiao, H., Han, Y., Shi, R., He, J., and Zhang, W. (2018, January 1\u20136). Loganin, a Major Iridoid Glycoside Obtained from Corni fructus, Exhibits Sleep-Enhancing Effects in Rodents. Proceedings of the Annual Meeting of the Japanese Pharmacological Society, WCP2018_PO2-12-15, Kyoto, Japan.","DOI":"10.1254\/jpssuppl.WCP2018.0_PO2-12-15"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Shi, R., Han, Y., Yan, Y., Qiao, H.-Y., He, J., Lian, W.-W., Xia, C.-Y., Li, T.-L., Zhang, W.-K., and Xu, J.-K. (2019). Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00409"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5152\/eurasianjmed.2018.17397","article-title":"Reactive Oxygen Species: The Dual Role in Physiological and Pathological Conditions of the Human Body","volume":"50","author":"Bardaweel","year":"2018","journal-title":"Eurasian J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s42255-018-0031-6","article-title":"Astrocytic Mitochondrial ROS Modulate Brain Metabolism and Mouse Behaviour","volume":"1","author":"Bonora","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chen, P., Wu, H., Yao, H., Zhang, J., Fan, W., Chen, Z., Su, W., Wang, Y., and Li, P. (2022). Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.847132"},{"key":"ref_105","first-page":"e22358","article-title":"Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss","volume":"15","author":"Nasehi","year":"2014","journal-title":"Shiraz E-Med. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/07853890.2015.1131327","article-title":"BDNF in Sleep, Insomnia, and Sleep Deprivation","volume":"48","author":"Schmitt","year":"2016","journal-title":"Ann. Med."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Fernandes, B.S., Molendijk, M.L., K\u00f6hler, C.A., Soares, J.C., Leite, C.M.G.S., Machado-Vieira, R., Ribeiro, T.L., Silva, J.C., Sales, P.M.G., and Quevedo, J. (2015). Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Bipolar Disorder: A Meta-Analysis of 52 Studies. BMC Med., 13.","DOI":"10.1186\/s12916-015-0529-7"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"101738","DOI":"10.1016\/j.smrv.2022.101738","article-title":"Peripheral Brain-Derived Neurotrophic Factor (BDNF) in Insomnia: A Systematic Review and Meta-Analysis","volume":"67","author":"Ballesio","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1503\/jpn.160228","article-title":"Meta-Analysis of Central and Peripheral \u03b3-Aminobutyric Acid Levels in Patients with Unipolar and Bipolar Depression","volume":"43","author":"Romeo","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"20190092","DOI":"10.1098\/rsfs.2019.0092","article-title":"Sleep Deprivation and Stress: A Reciprocal Relationship","volume":"10","author":"Nollet","year":"2020","journal-title":"Interface Focus"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid Bioavailability and Attempts for Bioavailability Enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1021\/mp7001363","article-title":"Commentary: Bioavailability of Flavonoids and Polyphenols: Call to Arms","volume":"4","author":"Hu","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wang, P., Zou, L., Han, H., and Zhang, T. (2024). A Simple and Sensitive LC\u2013MS\/MS Method for the Determination of Loganic Acid in Rat Plasma and Its Pharmacokinetic Analysis. Biomed. Chromatogr., 38.","DOI":"10.1002\/bmc.5951"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Isabel, U.-V., de la Riera, M.B.A., Dolores, R.S., and Elena, G.-B. (2024). A New Frontier in Neuropharmacology: Recent Progress in Natural Products Research for Blood\u2013Brain Barrier Crossing. Curr. Res. Biotechnol., 8.","DOI":"10.1016\/j.crbiot.2024.100235"}],"container-title":["Current Issues in Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/6\/399\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:42:07Z","timestamp":1760031727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1467-3045\/47\/6\/399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":114,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["cimb47060399"],"URL":"https:\/\/doi.org\/10.3390\/cimb47060399","relation":{},"ISSN":["1467-3045"],"issn-type":[{"value":"1467-3045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}