{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:52:08Z","timestamp":1781823128265,"version":"3.54.5"},"reference-count":72,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union-NextGenerationEU through the National Recovery and Resilience Plan of the Republic of Bulgaria","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]},{"name":"Resilience Plan of the Republic of Bulgaria","award":["BG-RRP-2.004-0004-C01"],"award-info":[{"award-number":["BG-RRP-2.004-0004-C01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) associated with recurrent inflammation and ulceration of the colonic mucosa. Conventional treatments, including corticosteroids, have significant side effects, driving the need for safer, effective alternatives. The present study aimed to investigate the mitigating effects of Epilobium angustifolium extract (EAE) in a Dextran sulfate sodium (DSS)-induced colitis mouse model, in a comparative manner to the reference drug dexamethasone (DXM). The severity and progression of colitis were evaluated through disease activity indices and a range of inflammatory and oxidative stress markers, assessed using multiple analytical methods. EAE treatment significantly reduced colonic inflammation, as indicated by decreased myeloperoxidase (MPO) activity, lower levels of malondialdehyde (MDA), and reduced white blood cell counts. EAE also enhanced antioxidant defenses, increasing glutathione (GSH) levels by 64%, and boosting catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities by 36%, 53%, and 70%, respectively. Histopathological analysis confirmed EAE\u2019s efficacy in attenuating colonic injury and inflammation. The blood parameters hemoglobin, erythrocytes, and hematocrit were also improved. Our study shows that EAE has potential as a natural therapeutic candidate for the treatment of UC, demonstrating efficacy comparable to that of conventional pharmacological treatments.<\/jats:p>","DOI":"10.3390\/cimb47060444","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:53:16Z","timestamp":1749559996000},"page":"444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ulceroprotective Effects of Epilobium angustifolium Extract in DSS-Induced Colitis in Mice"],"prefix":"10.3390","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-9053","authenticated-orcid":false,"given":"Rumyana","family":"Simeonova","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-0730","authenticated-orcid":false,"given":"Rositsa","family":"Mihaylova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-2419","authenticated-orcid":false,"given":"Reneta","family":"Gevrenova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonko","family":"Savov","sequence":"additional","affiliation":[{"name":"Institute of Emergency Medicine \u201cN. I. Pirogov\u201d, Bul. Totleben 21, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-9903","authenticated-orcid":false,"given":"Dimitrina","family":"Zheleva-Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saez, A., Herrero-Fernandez, B., Gomez-Bris, R., S\u00e1nchez-Martinez, H., and Gonzalez-Granado, J.M. (2023). Pathophysiology of Inflammatory Bowel Disease: Innate Immune System. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021526"},{"key":"ref_2","first-page":"w14599","article-title":"New insights into the pathophysiology of inflammatory bowel disease: Microbiota, epigenetics and common signalling pathways","volume":"148","author":"Luc","year":"2018","journal-title":"Swiss Med. Wkly."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2147\/CEOR.S481730","article-title":"Dose Escalation Patterns and Associated Costs of Advanced Therapies for Ulcerative Colitis in France and the United Kingdom: A Retrospective Database Analysis","volume":"17","author":"Treuer","year":"2025","journal-title":"Clin. Outcomes Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"i1014","DOI":"10.1093\/ecco-jcc\/jjae190.0655","article-title":"P0481 Real-World Analysis of Disease Progression in Ulcerative Colitis: A Comparative Study Across Diagnostic Eras at a Tertiary IBD Center","volume":"19","author":"Mirabent","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4252\/wjsc.v12.i10.1050","article-title":"Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy","volume":"12","author":"Mishra","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cai, Z., Wang, S., and Li, J. (2021). Treatment of Inflammatory Bowel Disease: A Comprehensive Review. Front. Med., 8.","DOI":"10.3389\/fmed.2021.765474"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"i397","DOI":"10.1093\/ecco-jcc\/jjab232.532","article-title":"P405 Primary non-response and loss-of-response to first-line biological therapies are more common in patients with Ulcerative Colitis than Crohn\u2019s Disease\u2014Preliminary results from the Danish IBD Biobank Project","volume":"16","author":"Zhao","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.dld.2020.05.031","article-title":"Incidence of suboptimal response to tumor necrosis factor antagonist therapy in inflammatory bowel disease in newly industrialised countries: The EXPLORE study","volume":"52","author":"Armuzzi","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1756283X17750355","DOI":"10.1177\/1756283X17750355","article-title":"Immunogenicity of biologics in inflammatory bowel disease","volume":"11","author":"Vermeire","year":"2018","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: Pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Calvez, V., Puca, P., Di Vincenzo, F., Del Gaudio, A., Bartocci, B., Murgiano, M., Iaccarino, J., Parand, E., Napolitano, D., and Pugliese, D. (2025). Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020305"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chong, J., Chen, Z., Ma, J., He, L., Zhu, Y., Lu, Z., Qiu, Z., Chen, C., Chen, Y., and Jiang, F. (2025). Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis\u2013A preclinical systematic review and meta-analysis. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-03629-0"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/ptr.6072","article-title":"Epilobium spp.: Pharmacology and Phytochemistry","volume":"32","author":"Vitalone","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_18","first-page":"449","article-title":"Epilobium angustifolium L.","volume":"Volume 7","author":"Kuzmanov","year":"1979","journal-title":"Flora Republicae Bulgaricae, Onagraceae"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jep.2014.08.036","article-title":"Phytochemistry, pharmacology and traditional uses of different Epilobium species (Onagraceae): A review","volume":"156","author":"Granica","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cbi.2018.09.021","article-title":"Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"298","author":"Pei","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gevrenova, R., Zengin, G., Ozturk, G., and Zheleva-Dimitrova, D. (2025). Exploring the Phytochemical Profile and Biological Insights of Epilobium angustifolium L. Herb. Plants, 14.","DOI":"10.3390\/plants14030415"},{"key":"ref_22","first-page":"152","article-title":"Gastroprotective Effect of oenothein B: A Romising Macrocyclic Ellagitannin","volume":"13","author":"Martins","year":"2024","journal-title":"Front. J. Soc. Technol. Environ. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1021\/jf2003267","article-title":"Gastroprotective and Ulcer-Healing Mechanisms of Ellagic Acid in Experimental Rats","volume":"59","author":"Beserra","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Shin, J.M., Son, Y.-J., Ha, I.J., Erdenebileg, S., Jung, D.S., Song, D., Kim, Y.S., Kim, S.M., and Nho, C.W. (2022). Artemisia argyi extract alleviates inflammation in a DSS-induced colitis mouse model and enhances immunomodulatory effects in lymphoid tissues. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03536-x"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2004.12.004","article-title":"Effects of angiotensin II type 1 receptor blockade on the oxidative stress in spontaneously hypertensive rat tissues","volume":"128","year":"2005","journal-title":"Regul. Pept."},{"key":"ref_26","first-page":"997","article-title":"Role of glutathione in the hypoxic cell cytotoxicity of misonidazole","volume":"43","author":"Bump","year":"1983","journal-title":"Cancer Res."},{"key":"ref_27","unstructured":"Tappel, A.L. (1978). hydroperoxides. Methods in Enzymology, Elsevier."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aebi, H. (1974). Catalase. Methods of Enzymatic Analysis, Elsevier.","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jnutbio.2014.12.001","article-title":"Effects of dietary virgin olive oil polyphenols: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol on DSS-induced acute colitis in mice","volume":"26","author":"Villegas","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_32","unstructured":"Bancroft, J.D., and Gamble, M. (2008). Theory and Practice of Histological Techniques; In Expertconsult, Churchill Livingstone\/Elsevier. [6th ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Almutary, A.G., Alnuqaydan, A.M., Almatroodi, S.A., and Tambuwala, M.M. (2023). Comparative Analysis of the Effect of Different Concentrations of Dextran Sodium Sulfate on the Severity and Extent of Inflammation in Experimental Ulcerative Colitis. Appl. Sci., 13.","DOI":"10.3390\/app13053233"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/ibd\/izad312","article-title":"Unveiling Colitis: A Journey Through the Dextran Sodium Sulfate-Induced Model","volume":"30","author":"Yang","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Subudhi, R.N., Poonia, N., Singh, D., and Arora, V. (2024). Natural approaches for the management of ulcerative colitis: Evidence of preclinical and clinical investigations. Nat. Prod. Bioprospect., 14.","DOI":"10.1007\/s13659-024-00463-x"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/10715760500197177","article-title":"Green tea polyphenol extract attenuates colon injury induced by experimental colitis","volume":"39","author":"Mazzon","year":"2005","journal-title":"Free Radic. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Oliyaei, N., Zekri, S., Iraji, A., Oliyaei, A., Tanideh, R., Mussin, N.M., Tamadon, A., and Tanideh, N. (2025). Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms. J. Funct., 125.","DOI":"10.1016\/j.jff.2025.106690"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Long, D., Zhang, W., Mao, C., Zhu, Y., and Xu, Y. (2025). Natural products for the treatment of ulcerative colitis: Focus on the JAK\/STAT pathway. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1538302"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ijbiomac.2022.04.208","article-title":"Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review","volume":"210","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"119717","DOI":"10.1016\/j.jep.2025.119717","article-title":"Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice","volume":"346","author":"He","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhang, X., Zhang, F., Li, Y., Fan, N., Zhao, K., Zhang, A., Kang, J., Lin, Y., Xue, X., and Jiang, X. (2024). Blockade of PI3K\/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier. J. Transl. Med., 22.","DOI":"10.1186\/s12967-024-05168-w"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pellegrini, C., Fornai, M., Colucci, R., Benvenuti, L., D\u2019Antongiovanni, V., Natale, G., Fulceri, F., Giorgis, M., Marini, E., and Gastaldi, S. (2018). A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-Clinical Model of Bowel Inflammation. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01405"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Salem, H.A., and Wadie, W. (2017). Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-07280-y"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3748\/wjg.v26.i24.3365","article-title":"Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways","volume":"26","author":"Kamalian","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0002-9440(10)64587-7","article-title":"The Role of Cyclooxygenase 2 in Ulcerative Colitis-Associated Neoplasia","volume":"157","author":"Crispin","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_46","first-page":"101547","article-title":"The therapeutic effect of antioxidant postbiotic cocktail in colitis mice: A promising approach to alleviate oxidative stress in two high-fat and normal-diet feeding mice","volume":"19","author":"Rezaie","year":"2025","journal-title":"J. Agric. Food Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., and Mao, Z. (2024). The emerging role of oxidative stress in inflammatory bowel disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1390351"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"San Gabriel, P.T., O\u2019Neil, T.R., Au, A., Tan, J.K., Pinget, G.V., Liu, Y., Fong, G., Ku, J., Glaros, E., and Macia, L. (2024). Myeloperoxidase Gene Deletion Causes Drastic Microbiome Shifts in Mice and Does Not Mitigate Dextran Sodium Sulphate-Induced Colitis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084258"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"iii37","DOI":"10.1136\/gut.50.suppl_3.iii37","article-title":"Influence of treatment on morphological features of mucosal inflammation","volume":"50","author":"Geboes","year":"2002","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.-H., and Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25.","DOI":"10.3390\/molecules25225243"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Vezza, T., Rodr\u00edguez-Nogales, A., Algieri, F., Utrilla, M., Rodriguez-Cabezas, M., and Galvez, J. (2016). Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients, 8.","DOI":"10.3390\/nu8040211"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Xue, J.-C., Yuan, S., Meng, H., Hou, X.-T., Li, J., Zhang, H.-M., Chen, L.-L., Zhang, C.-H., and Zhang, Q.-G. (2023). The role and mechanism of flavonoid herbal natural products in ulcerative colitis. Biomed. Pharmacother., 158.","DOI":"10.1016\/j.biopha.2022.114086"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.3748\/wjg.v23.i28.5097","article-title":"Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review","volume":"23","author":"Salaritabar","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Wen, F., Sun, F., Xu, Z., Liu, Y., Tao, C., Sun, F., Jiang, M., Yang, M., and Yao, J. (2022). Efficacy and Mechanism of Quercetin in the Treatment of Experimental Colitis Using Network Pharmacology Analysis. Molecules, 28.","DOI":"10.3390\/molecules28010146"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Li, H., Ruan, J., Huang, J., Yang, D., Yu, H., Wu, Y., Zhang, Y., and Wang, T. (2023). Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417538"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/ptr.6625","article-title":"Phytochemical drug candidates for the modulation of peroxisome proliferator-activated receptor \u03b3 in inflammatory bowel diseases","volume":"34","author":"Venkataraman","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00394-024-03577-7","article-title":"Ellagic acid alleviates DSS\u2013induced ulcerative colitis by inhibiting ROS\/NLRP3 pathway activation and modulating gut microbiota in mice","volume":"64","author":"Xiong","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.2147\/DDDT.S86345","article-title":"Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB\/c mice","volume":"9","author":"Pandurangan","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.phymed.2010.10.016","article-title":"Oenothein B\u2019s contribution to the anti-inflammatory and antioxidant activity of Epilobium sp.","volume":"18","author":"Kiss","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.4049\/jimmunol.0901827","article-title":"Immunomodulatory Activity of Oenothein B Isolated from Epilobium angustifolium","volume":"183","author":"Schepetkin","year":"2009","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Qu, Y., Li, X., Xu, F., Zhao, S., Wu, X., Wang, Y., and Xie, J. (2021). Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-\u03baB Axis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.679897"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10620-011-1883-8","article-title":"Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice","volume":"57","author":"Park","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.biopha.2018.09.081","article-title":"Oenothera rosea L\u2019H\u00e9r. ex Ait attenuates acute colonic inflammation in TNBS-induced colitis model in rats: In vivo and in silico myeloperoxidase role","volume":"108","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.3390\/molecules16043338","article-title":"Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties","volume":"16","author":"Rho","year":"2011","journal-title":"Molecules"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1476-511X-12-115","article-title":"The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits","volume":"12","author":"Kong","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_66","first-page":"1","article-title":"Blockade of Airway Inflammation by Kaempferol via Disturbing Tyk-STAT Signaling in Airway Epithelial Cells and in Asthmatic Mice","volume":"2013","author":"Gong","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"H212","DOI":"10.1111\/j.1750-3841.2010.01755.x","article-title":"Evaluation of Antioxidant and Inhibitory Activities for Different Subclasses Flavonoids on Enzymes for Rheumatoid Arthritis","volume":"75","author":"Lee","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9580","DOI":"10.1080\/10408398.2022.2067121","article-title":"Kaempferol: A flavonoid with wider biological activities and its applications","volume":"63","author":"Bangar","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3892\/ijmm.2013.1468","article-title":"Kaempferol inhibits IL-1\u03b2-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs","volume":"32","author":"Yoon","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/mmr.2012.1225","article-title":"Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis","volume":"7","author":"Zhao","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zieniuk, B. (2023). Dihydrocaffeic Acid\u2014Is It the Less Known but Equally Valuable Phenolic Acid?. Biomolecules, 13.","DOI":"10.3390\/biom13050859"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.foodres.2016.06.011","article-title":"Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells","volume":"87","author":"Baeza","year":"2016","journal-title":"Food Res. 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