{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:03:25Z","timestamp":1778720605659,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Department of Guizhou Province","award":["ZK [2022]-general-161"],"award-info":[{"award-number":["ZK [2022]-general-161"]}]},{"name":"Science and Technology Department of Guizhou Province","award":["[2020]075"],"award-info":[{"award-number":["[2020]075"]}]},{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","award":["ZK [2022]-general-161"],"award-info":[{"award-number":["ZK [2022]-general-161"]}],"id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","award":["[2020]075"],"award-info":[{"award-number":["[2020]075"]}],"id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIMB"],"abstract":"<jats:p>Nerve injury caused by chemotherapy drugs is a common side effect. How to reduce this kind of nerve injury and promote neuron recovery is of great significance. In this study, we found that tumor necrosis factor-\u03b1 (TNF-\u03b1) promoted the recovery of dorsal root ganglion (DRG) neuron from cisplatin-induced injury. On DRG neurons cultured in vitro, we found that TNF-\u03b1 promoted neurite regeneration after cisplatin injury. In addition, TNF-\u03b1 accelerated the removal of DNA damage and promoted the regeneration of mitochondria on DRG neurons. Study of the mechanism showed that this effect of TNF-\u03b1 was independent from the NGF signaling pathway and occurred mostly through the activation of TNFR2 receptors, together with nucleus translocation of p65 and upregulation of NF-\u03baB expression. This study provides a new theoretical basis and therapeutic strategy for the treatment of nerve injury caused by chemotherapy drugs.<\/jats:p>","DOI":"10.3390\/cimb47070482","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T08:50:57Z","timestamp":1750755057000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TNF-\u03b1 Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism"],"prefix":"10.3390","volume":"47","author":[{"given":"Yiling","family":"Wei","sequence":"first","affiliation":[{"name":"Medical School, Guizhou University, Guiyang 550000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Preclinical Medicine, Zunyi Medical University, Zunyi 563100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical School, Guizhou University, Guiyang 550000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical School, Guizhou University, Guiyang 550000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingmei","family":"Mo","sequence":"additional","affiliation":[{"name":"Medical School, Guizhou University, Guiyang 550000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Medical School, Guizhou University, Guiyang 550000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy-induced peripheral neuropathy: A current review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. 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